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DNA Repair & Genome Editing

DNA Repair & Genome Editing diagram by Ata et al, PLOS Genetics
Ata et al, PLOS Genetics

Development of gene editing techniques, including CRISPR and TALENs, has relied on mechanisms that underlie DNA repair and genome stability pathways. This feed focuses on the role of DNA repair mechanisms in gene editing and genetic engineering.

Top 20 most recent papers

Improved bacterial recombineering by parallelized protein discovery

bioRxivJanuary 16, 2020
Timothy M WannierGeorge M Church

RECAS9: Recombining wild species introgression via mitotic gene editing in barley

bioRxivJanuary 8, 2020
Shelly LazarEyal Fridman

Correlation-based and feature-driven mutation signature analyses to identify genetic features associated with DNA mutagenic processes in cancer genomes

bioRxivJanuary 6, 2020
Hye Young JeongTae-Min Kim

Fast and efficient generation of knock-in human organoids using homology-independent CRISPR/Cas9 precision genome editing

bioRxivJanuary 15, 2020
Benedetta ArtegianiHans Clevers

Recurrent pre-leukemic deletions in myeloid malignancies are the result of DNA double-strand breaks followed by microhomology-mediated end joining

bioRxivJanuary 2, 2020
Tzah FeldmanLiran I Shlush
Molecular Therapy. Methods & Clinical Development

AAV-Mediated CRISPR/Cas9 Gene Editing in Murine Phenylketonuria

Molecular Therapy. Methods & Clinical DevelopmentJanuary 24, 2020
Daelyn Y RichardsCary O Harding
Biochemical Society Transactions

Characterization and applications of Type I CRISPR-Cas systems

Biochemical Society TransactionsJanuary 11, 2020
Claudio Hidalgo-Cantabrana, Rodolphe Barrangou
Clinical Cancer Research : an Official Journal of the American Association for Cancer Research

Restoration of Temozolomide Sensitivity by Poly(ADP-Ribose) Polymerase inhibitors in Mismatch Repair Deficient Glioblastoma is Independent of Base Excision Repair

Clinical Cancer Research : an Official Journal of the American Association for Cancer ResearchJanuary 5, 2020
Fumi HiguchiDaniel P Cahill

Comparison of CRISPR and marker based methods for the engineering of phage T7

bioRxivJanuary 13, 2020
Aurelija M GrigonyteAndrew D Millard
Scientific Reports

Indel locations are determined by template polarity in highly efficient in vivo CRISPR/Cas9-mediated HDR in Atlantic salmon

Scientific ReportsJanuary 17, 2020
Anne Hege StraumeRolf Brudvik Edvardsen

Cas9/gRNA-mediated genome editing of yeast mitochondria and Chlamydomonas chloroplasts

PeerJJanuary 15, 2020
Byung-Chun YooHajime Sakai

Development of Gene Editing Strategies for Human β-Globin (HBB) Gene Mutations

bioRxivJanuary 17, 2020
Batuhan M KalkanFatih Kocabas
Molecular Therapy. Nucleic Acids

Correction of the aprt Gene Using Repair-Polypurine Reverse Hoogsteen Hairpins in Mammalian Cells

Molecular Therapy. Nucleic AcidsJanuary 17, 2020
Alex J FélixVéronique Noé
Molecular Therapy. Nucleic Acids

A Universal Surrogate Reporter for Efficient Enrichment of CRISPR/Cas9-Mediated Homology-Directed Repair in Mammalian Cells

Molecular Therapy. Nucleic AcidsJanuary 20, 2020
Nana YanZhiying Zhang
Methods in Molecular Biology

Engineering Mutation Clones in Mammalian Cells with CRISPR/Cas9

Methods in Molecular BiologyJanuary 16, 2020
Zijun HuoRuiying Zhao

Efficient replacement of long DNA fragments via non-homologous end joining at non-doding regions

bioRxivJanuary 14, 2020
Shan-Ye GuJiu-Lin Du
European Journal of Heart Failure

Hypertrophic cardiomyopathy: the future of treatment

European Journal of Heart FailureJanuary 11, 2020
C Vaughan TuohyStephen B Heitner
International Journal of Molecular Sciences

Changes in Proteome and Protein Phosphorylation Reveal the Protective Roles of Exogenous Nitrogen in Alleviating Cadmium Toxicity in Poplar Plants

International Journal of Molecular SciencesJanuary 8, 2020
Jinliang HuangTiantian Lin

Deficiency of Circulating Monocytes Ameliorates the Progression of Myxomatous Valve Degeneration in Marfan Syndrome

CirculationJanuary 14, 2020
Andrew J KimKatherine E Yutzey
Asian Journal of Urology

Tissue engineered indigenous pericardial patch urethroplasty: A promising solution to a nagging problem

Asian Journal of UrologyJanuary 24, 2020
Tapan K MandalMaharaj Mondal

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