DNA Repair & Genome Editing

Development of gene editing techniques, including CRISPR and TALENs, has relied on mechanisms that underlie DNA repair and genome stability pathways. This feed focuses on the role of DNA repair mechanisms in gene editing and genetic engineering.

January 16, 2021

CRISPR base editing applications for identifying cancer-driving mutations

Biochemical Society Transactions
Martin Pal, Marco J Herold
January 16, 2021

Cardiac Stromal Cell Patch Integrated with Engineered Microvessels Improves Recovery from Myocardial Infarction in Rats and Pigs

ACS Biomaterials Science & Engineering
Teng SuKe Cheng
January 6, 2021

CRISPR/dCas-mediated transcriptional and epigenetic regulation in plants

Current Opinion in Plant Biology
Changtian PanYiping Qi
December 28, 2020
Open Access

Therapeutic vulnerability to PARP1/2 inhibition in RB1-mutant osteosarcoma

BioRxiv : the Preprint Server for Biology
G. ZoumpoulidouSibylle Mittnacht
January 15, 2021
Open Access

Engineered dual selection for directed evolution of SpCas9 PAM specificity

Nature Communications
Gregory W GoldbergMarcus B Noyes
January 1, 2021
Open Access

Strategies for Peripheral Nerve Repair

Current Tissue Microenvironment Reports
Matthew WilcoxJames B Phillips
January 6, 2021
Open Access

Harnessing CRISPR-Cas9 for genome editing in Streptococcus pneumoniae D39V

Applied and Environmental Microbiology
Dimitra Synefiaridou, Jan-Willem Veening
January 15, 2021

Real-time observation of Cas9 postcatalytic domain motions

Proceedings of the National Academy of Sciences of the United States of America
Yanbo WangTaekjip Ha
December 29, 2020
Open Access

Engineering large chromosomal deletions by CRISPR-Cas9

BioRxiv : the Preprint Server for Biology
T. F. EleveldBauke Ylstra
January 15, 2021
Open Access

CRISPR/Cas-9 mediated knock-in by homology dependent repair in the West Nile Virus vector Culex quinquefasciatus Say

BioRxiv : the Preprint Server for Biology
D.-K. PurusothamanLuke Alphey
January 2, 2021

CRISPR-cas9 genome editing delivery systems for targeted cancer therapy

Life Sciences
Asma GhaemiMona Alibolandi
January 12, 2021

Composite engineered biomaterial adaptable for repair and regeneration of wounds

Wound Repair and Regeneration : Official Publication of the Wound Healing Society [and] the European Tissue Repair Society
Yidi Wu, William D Wagner
January 2, 2021
Open Access

Precise genomic deletions using paired prime editing

BioRxiv : the Preprint Server for Biology
J. ChoiJay Shendure
January 6, 2021
Open Access

CRISPR/Cas9 Induced Somatic Recombination at the CRTISO Locus in Tomato

Ilan Ben ShlushAvraham A Levy
January 6, 2021

Biofunctional ECM-PCL-HA Scaffold and SMSCs / Chondrocytes for Repairing Cartilage Defects

Tissue Engineering. Part a
Yingjie XuZhongcheng Gong
January 20, 2021

ALC1 links chromatin accessibility to PARP inhibitor response in homologous recombination-deficient cells

Nature Cell Biology
Priyanka VermaRoger A Greenberg

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