DNA Repair & Genome Editing

Development of gene editing techniques, including CRISPR and TALENs, has relied on mechanisms that underlie DNA repair and genome stability pathways. This feed focuses on the role of DNA repair mechanisms in gene editing and genetic engineering.

May 16, 2020
Open Access

Rapid, modular, and cost-effective generation of donor DNA constructs for CRISPR-based gene knock-in

Biology Methods and Protocols
Yi-Jiun ChenJianhua Xing
May 20, 2020

Cas9 activates the p53 pathway and selects for p53-inactivating mutations

Nature Genetics
Oana M EnacheUri Ben-David
May 26, 2020

Xenotransplantation of decellularized pig heart valves-Regulatory aspects in Europe

Antonia W Godehardt, Ralf R Tönjes
May 18, 2020

Expanding the substrate selectivity of SNAP/CLIP-tagging of intracellular targets

Methods in Enzymology
Miguel Macias-ContrerasLei Zhu
May 7, 2020

New Insights into Valve Hemodynamics

Rambam Maimonides Medical Journal
Gil Marom, Shmuel Einav
May 7, 2020
Open Access

Multiple site-directed mutagenesis via simple cloning by prolonged overlap extension

Rasmus Hejlesen, Ernst-Martin Füchtbauer
May 28, 2020

Detection of Deleterious On-Target Effects after HDR-Mediated CRISPR Editing

Cell Reports
Isabel WeisheitDominik Paquet
May 30, 2020

Engineered Mesenchymal Stromal Cell Therapy during Human Lung Ex Vivo Lung Perfusion is Affected by Lung Acidosis

The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation
A I NykanenS Keshavjee
May 24, 2020

Antibacterial Fusion Protein BPI21/LL-37 Modification Enhances the Therapeutic Efficacy of hUC-MSCs in Sepsis

Molecular Therapy : the Journal of the American Society of Gene Therapy
Zhan LiXiang Xu
May 6, 2020
Open Access

Efficient correction of a deleterious point mutation in primary horse fibroblasts with CRISPR-Cas9

Scientific Reports
Carlos Pinzon-ArteagaCharles R Long
June 2, 2020

Correction of muscular dystrophies by CRISPR gene editing

The Journal of Clinical Investigation
Francesco ChemelloEric N Olson

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