Feed Preview

DNA Repair & Genome Editing

DNA Repair & Genome Editing diagram by Hirotaka Ata et al
Hirotaka Ata et al

Development of gene editing techniques, including CRISPR and TALENs, has relied on mechanisms that underlie DNA repair and genome stability pathways. This feed focuses on the role of DNA repair mechanisms in gene editing and genetic engineering.

Top 20 most recent papers
Nature Communications

Ranking of non-coding pathogenic variants and putative essential regions of the human genome

Nature CommunicationsNovember 20, 2019
Alex WellsJulia Di Iulio
87
bioRxiv

CtIP -mediated alternative mRNA splicing finetunes the DNA damage response

bioRxivNovember 21, 2019
Rosario Prados-CarvajalPablo Huertas
2
Nature Communications

Both fallopian tube and ovarian surface epithelium are cells-of-origin for high-grade serous ovarian carcinoma

Nature CommunicationsNovember 26, 2019
Shuang ZhangBenjamin G. Neel
56
11
Nature Communications

Highly efficient multiplex human T cell engineering without double-strand breaks using Cas9 base editors

Nature CommunicationsNovember 19, 2019
Beau R. WebberBranden S. Moriarity
26
2
Nature Communications

Targeting specificity of APOBEC-based cytosine base editor in human iPSCs determined by whole genome sequencing

Nature CommunicationsNovember 25, 2019
Erica McGrathZhaohui Ye
23
bioRxiv

Differential efficacies of Cas nucleases on microsatellites involved in human disorders and associated off-target mutations

bioRxivNovember 29, 2019
Lucie PoggiGuy-Franck Richard
6
Nature Communications

Transcription elongation factor AFF2/FMR2 regulates expression of expanded GGGGCC repeat-containing C9ORF72 allele in ALS/FTD

Nature CommunicationsNovember 29, 2019
Yeliz Yuva-AydemirFen-Biao Gao
12
bioRxiv

Efficient Homology-directed Repair with Circular ssDNA Donors

bioRxivDecember 5, 2019
Sukanya IyerScot A. Wolfe
Nature Communications

Publisher Correction: An engineered human Fc domain that behaves like a pH-toggle switch for ultra-long circulation persistence

Nature CommunicationsNovember 26, 2019
Chang-Han LeeGeorge Georgiou
Nucleic Acids Research

Expanding the editable genome and CRISPR-Cas9 versatility using DNA cutting-free gene targeting based on in trans paired nicking

Nucleic Acids ResearchDecember 4, 2019
Xiao-Yu ChenManuel A F V Gonçalves
Nature Communications

CRISPR-Switch regulates sgRNA activity by Cre recombination for sequential editing of two loci

Nature CommunicationsNovember 29, 2019
Krzysztof ChylinskiUlrich Elling
54
9
Biomaterials

Mesenchymal Stromal Cells from Patients with Cyanotic Congenital Heart Disease are Optimal Candidate for Cardiac Tissue Engineering

BiomaterialsNovember 6, 2019
Kai KangShu-Lin Jiang
Nature Communications

A general orientation distribution function for clay-rich media

Nature CommunicationsNovember 29, 2019
Thomas DabatEric Ferrage
5
bioRxiv

High-efficiency multi-site genomic editing (HEMSE) of Pseudomonas putida through thermoinducible ssDNA recombineering

bioRxivNovember 21, 2019
Tomas AparicioVíctor de Lorenzo
20
bioRxiv

Peripheral Nerve Repair Using Tissue Engineered Living Scaffolds Comprised of Stretch-Grown Aligned Axonal Tracts Promotes Survival of Spinal Cord Motor Neurons

bioRxivNovember 20, 2019
JOSEPH C MAGGIOREDaniel Kacy Cullen
5
Science China. Life Sciences

Crystal structure of Cas1 in complex with branched DNA

Science China. Life SciencesNovember 28, 2019
Jing YangYan-li Wang
Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences

Manipulating and elucidating mitochondrial gene expression with engineered proteins

Philosophical Transactions of the Royal Society of London. Series B, Biological SciencesDecember 4, 2019
Christopher P WallisOliver Rackham
Stem Cell Research

Generation of Rybp homozygous knockout murine ES cell line GIBHe001-A-1 by using CRISPR/Cas9 technology

Stem Cell ResearchOctober 26, 2019
Zicong LiuBao-ming Qin
bioRxiv

A minimal CRISPR-Cas3 system for genome engineering

bioRxivDecember 3, 2019
Bálint CsörgoJoseph Bondy-Denomy
77
Journal of Neurology

Novel NAXE variants as a cause for neurometabolic disorder: implications for treatment

Journal of NeurologyNovember 20, 2019
Joanne TrinhNorbert Brüggemann

See more papers from this feed

Related Feeds

AAV-based Gene Therapy

Adeno-associated virus (AAV)-based gene therapy is a biological vector that is being researched to be used as a potential therapeutic option. This gene therapy is designed to insert fragments of DNA into targeted cells to help treat diseases, such as hemophilia a. Discover the latest research on AAV-based gene therapy here.

ALS: Genetics

Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disorder characterized by muscle weakness. ALS is a genetically heterogeneous disorder with several causative genes. Here are the latest discoveries pertaining to the genetics of this disease.

ATG proteins

The discovery of autophagy-related ('ATG') proteins in the 1990s greatly advanced the mechanistic understanding of autophagy and clarified the fact that autophagy serves important roles in various biological processes.

Acute Myeloid Leukaemia & RNA

Acute myeloid leukaemia (AML) is a common hematological type of cancer. As the population ages, there has been a rise in the frequency of AML. RNA expression has been used to see if there are different genetic profiles that exist within AML and whether these may underpin the variations in survival rates. Here is the latest research on AML and RNA.

Alignment-free Sequence Analysis Tools

Alignment-free sequence analyses have been applied to problems ranging from whole-genome phylogeny to the classification of protein families, identification of horizontally transferred genes, and detection of recombined sequences. Here is the latest research.

Alzheimer's Disease: Genetics

Alzheimer's disease is a chronic neurodegenerative disease. Discover genetic and epigenetic aspects of Alzheimer’s disease, including genetic markers and genomic structural variations here.

Alzheimer's Disease: RNA Sequencing

RNA sequencing is used to reveal the presence and quantity of RNA in a given sample. In this feed, RNA sequencing investigates the genetic and molecular mechanisms related to the pathophysiology of Alzheimer's disease (AD). Here are the latest discoveries pertaining to RNA sequencing and this disease.

Antisense Oligonucleotides: ND

This feed focuses on antisense oligonucleotide therapies such as Inotersen, Nusinursen, and Patisiran, in neurodegenerative diseases including amyotrophic lateral sclerosis.

Apoptotic Caspases

Apoptotic caspases belong to the protease enzyme family and are known to play an essential role in inflammation and programmed cell death. Here is the latest research.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

© 2019 Meta ULC. All rights reserved
/feed-previews/dna-repair-genome-editing/645101bf-5971-46ac-9c33-ba8d66ec27fb