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DNA Repair & Genome Editing

DNA Repair & Genome Editing diagram by Hirotaka Ata et al
Hirotaka Ata et al

Development of gene editing techniques, including CRISPR and TALENs, has relied on mechanisms that underlie DNA repair and genome stability pathways. This feed focuses on the role of DNA repair mechanisms in gene editing and genetic engineering.

Top 20 most recent papers
Nature Communications

Ranking of non-coding pathogenic variants and putative essential regions of the human genome

Nature CommunicationsNovember 20, 2019
Alex WellsJulia Di Iulio

CtIP -mediated alternative mRNA splicing finetunes the DNA damage response

bioRxivNovember 21, 2019
Rosario Prados-CarvajalPablo Huertas
Nature Communications

Both fallopian tube and ovarian surface epithelium are cells-of-origin for high-grade serous ovarian carcinoma

Nature CommunicationsNovember 26, 2019
Shuang ZhangBenjamin G. Neel
Nature Communications

Highly efficient multiplex human T cell engineering without double-strand breaks using Cas9 base editors

Nature CommunicationsNovember 19, 2019
Beau R. WebberBranden S. Moriarity
Nature Communications

Targeting specificity of APOBEC-based cytosine base editor in human iPSCs determined by whole genome sequencing

Nature CommunicationsNovember 25, 2019
Erica McGrathZhaohui Ye

Differential efficacies of Cas nucleases on microsatellites involved in human disorders and associated off-target mutations

bioRxivNovember 29, 2019
Lucie PoggiGuy-Franck Richard
Nature Communications

Transcription elongation factor AFF2/FMR2 regulates expression of expanded GGGGCC repeat-containing C9ORF72 allele in ALS/FTD

Nature CommunicationsNovember 29, 2019
Yeliz Yuva-AydemirFen-Biao Gao

Efficient Homology-directed Repair with Circular ssDNA Donors

bioRxivDecember 5, 2019
Sukanya IyerScot A. Wolfe
Nature Communications

Publisher Correction: An engineered human Fc domain that behaves like a pH-toggle switch for ultra-long circulation persistence

Nature CommunicationsNovember 26, 2019
Chang-Han LeeGeorge Georgiou
Nucleic Acids Research

Expanding the editable genome and CRISPR-Cas9 versatility using DNA cutting-free gene targeting based on in trans paired nicking

Nucleic Acids ResearchDecember 4, 2019
Xiao-Yu ChenManuel A F V Gonçalves
Nature Communications

CRISPR-Switch regulates sgRNA activity by Cre recombination for sequential editing of two loci

Nature CommunicationsNovember 29, 2019
Krzysztof ChylinskiUlrich Elling

Mesenchymal Stromal Cells from Patients with Cyanotic Congenital Heart Disease are Optimal Candidate for Cardiac Tissue Engineering

BiomaterialsNovember 6, 2019
Kai KangShu-Lin Jiang
Nature Communications

A general orientation distribution function for clay-rich media

Nature CommunicationsNovember 29, 2019
Thomas DabatEric Ferrage

High-efficiency multi-site genomic editing (HEMSE) of Pseudomonas putida through thermoinducible ssDNA recombineering

bioRxivNovember 21, 2019
Tomas AparicioVíctor de Lorenzo

Peripheral Nerve Repair Using Tissue Engineered Living Scaffolds Comprised of Stretch-Grown Aligned Axonal Tracts Promotes Survival of Spinal Cord Motor Neurons

bioRxivNovember 20, 2019
Science China. Life Sciences

Crystal structure of Cas1 in complex with branched DNA

Science China. Life SciencesNovember 28, 2019
Jing YangYan-li Wang
Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences

Manipulating and elucidating mitochondrial gene expression with engineered proteins

Philosophical Transactions of the Royal Society of London. Series B, Biological SciencesDecember 4, 2019
Christopher P WallisOliver Rackham
Stem Cell Research

Generation of Rybp homozygous knockout murine ES cell line GIBHe001-A-1 by using CRISPR/Cas9 technology

Stem Cell ResearchOctober 26, 2019
Zicong LiuBao-ming Qin

A minimal CRISPR-Cas3 system for genome engineering

bioRxivDecember 3, 2019
Bálint CsörgoJoseph Bondy-Denomy
Journal of Neurology

Novel NAXE variants as a cause for neurometabolic disorder: implications for treatment

Journal of NeurologyNovember 20, 2019
Joanne TrinhNorbert Brüggemann

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