DNA Repair in Primary Cell Systems

Cells are subjected to several DNA damaging events on a daily basis which results in the induction of DNA damage signaling and repair cascades to ensure genomic integrity. Here is the latest research on DNA damage signaling and repair mechanisms in primary cells.

January 20, 2022

Nuclear and mitochondrial DNA editing in human cells with zinc finger deaminases.

Nature Communications
Kayeong LimJin-Soo Kim
January 19, 2022
Open Access

CRISPR Therapeutics for Duchenne Muscular Dystrophy

Esra Erkut, Toshifumi Yokota
January 19, 2022

Targeting PTPN22 does not enhance the efficacy of CAR T cells in solid tumours.

Molecular and Cellular Biology
Xin DuTony Tiganis
January 19, 2022

ChREBPβ is dispensable for the control of glucose homeostasis and energy balance.

JCI Insight
Emeline RecazensDominique Langin
January 19, 2022
Open Access

Confounds of using the unc-58 selection marker highlights the importance of genotyping co-CRISPR genes.

PloS One
Helena Rawsthorne-ManningJames Dillon
January 19, 2022

The SF3B1R625H mutation promotes prolactinoma tumor progression through aberrant splicing of DLG1.

Journal of Experimental & Clinical Cancer Research : CR
Jing GuoYazhuo Zhang
January 19, 2022

Neuron navigator 3 (NAV3) is required for heart development in zebrafish.

Fish Physiology and Biochemistry
Feng LvChangsheng Chen
January 19, 2022

Nanoparticle-based non-viral CRISPR delivery for enhanced immunotherapy.

Chemical Communications : Chem Comm
Hyunsu Shin, Jaeyun Kim
January 19, 2022

Smart Strategies for Precise Delivery of CRISPR/Cas9 in Genome Editing.

ACS Applied Bio Materials
Akbar HasanzadehMichael R Hamblin
January 17, 2022

Structural and biochemical characterization of human Schlafen 5.

Nucleic Acids Research
Felix J MetznerKatja Lammens
January 17, 2022

53BP1-ACLY-SLBP-coordinated activation of replication-dependent histone biogenesis maintains genomic integrity.

Nucleic Acids Research
TingTing WuHo Jin You
January 17, 2022

A comparison of DNA repair pathways to achieve a site-specific gene modification of the Bruton's tyrosine kinase gene.

Molecular Therapy. Nucleic Acids
David H GrayCaroline Y Kuo

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