DNA Repair in Primary Cell Systems

Cells are subjected to several DNA damaging events on a daily basis which results in the induction of DNA damage signaling and repair cascades to ensure genomic integrity. Here is the latest research on DNA damage signaling and repair mechanisms in primary cells.

August 29, 2020
Open Access

Recent advances in the nucleolar responses to DNA double-strand breaks

Nucleic Acids Research
Lea Milling KorsholmDorthe Helena Larsen
September 1, 2020
Preprint
Open Access

RecT recombinase expression enables efficient gene editing in Enterococcus

BioRxiv : the Preprint Server for Biology
V. ChenHoward C Hang
September 5, 2020
Review

Modulation of DNA double-strand break repair as a strategy to improve precise genome editing

Oncogene
Ujjayinee Ray, Sathees C Raghavan
September 10, 2020
Open Access

Gene-Editing Technologies Paired With Viral Vectors for Translational Research Into Neurodegenerative Diseases

Frontiers in Molecular Neuroscience
Joseph Edward RittinerBoris Kantor
September 15, 2020

Detection of CRISPR/Cas9-Generated Off-Target Effect by Integration-Defective Lentiviral Vector

Methods in Molecular Biology
Xiaoling WangJiing-Kuan Yee
September 8, 2020
Open Access

Comprehensive classification of ABC ATPases and their functional radiation in nucleoprotein dynamics and biological conflict systems

Nucleic Acids Research
Arunkumar KrishnanL Aravind
September 6, 2020
Open Access

Clinical PARP inhibitors do not abrogate PARP1 exchange at DNA damage sites in vivo

Nucleic Acids Research
Zhengping ShaoShan Zha
September 12, 2020
Open Access

Rapid, precise quantification of large DNA excisions and inversions by ddPCR

Scientific Reports
Hannah L WatryLuke M Judge
September 10, 2020
Open Access

Functional classification of prostate cancer‑associated miRNAs through CRISPR/Cas9‑mediated gene knockout

Molecular Medicine Reports
Fu-Neng JiangWei-De Zhong
September 6, 2020
Open Access

SPOC1 modulates DNA repair by regulating key determinants of chromatin compaction and DNA damage response

Nucleic Acids Research
Andreas MundHans Will
September 26, 2020
Review
Open Access

Key Players in the Mutant p53 Team: Small Molecules, Gene Editing, Immunotherapy

Frontiers in Oncology
Vitaly ChasovEmil Bulatov
September 19, 2020

Targeted Transgenic Mice Using CRISPR /Cas9 Technology

Methods in Molecular Biology
Fatima El MarjouDenis Krndija
September 19, 2020

A robust and practical CRISPR/crRNA screening system for soybean cultivar editing using LbCpf1 ribonucleoproteins

Plant Cell Reports
Hyeran Kim, Jisun Choi
September 6, 2020
Open Access

PEG-Delivered CRISPR-Cas9 Ribonucleoproteins System for Gene-Editing Screening of Maize Protoplasts

Genes
Rodrigo Ribeiro Arnt Sant'AnaSarah Zanon Agapito-Tenfen
September 1, 2020
Open Access

Assessing Public Opinion on CRISPR-Cas9: Combining Crowdsourcing and Deep Learning

Journal of Medical Internet Research
Martin MüllerEffy Vayena
September 15, 2020
Review

CRISPR-Cas-mediated gene editing in lactic acid bacteria

Molecular Biology Reports
Xin SongLian-Zhong Ai

Sign up to follow this feed and discover related papers.

Related Feeds

ATG proteins

The discovery of autophagy-related ('ATG') proteins in the 1990s greatly advanced the mechanistic understanding of autophagy and clarified the fact that autophagy serves important roles in various biological processes.

Apoptotic Caspases

Apoptotic caspases belong to the protease enzyme family and are known to play an essential role in inflammation and programmed cell death. Here is the latest research.

Autophagosome

An autophagosome is the formation of double-membrane vesicles that involve numerous proteins and cytoplasmic components. These double-membrane vesicles are then terminated at the lysosome where they are degraded. Discover the latest research on autophagosomes here.

Autophagy & Aging: Inhibitors

The feed focuses on the role of nuclear export inhibitors and their effect on autophagy and the aging process.

Autophagy & Disease

Autophagy is an important cellular process for normal physiology and both elevated and decreased levels of autophagy are associated with disease. Here is the latest research.

Autophagy & Metabolism

Autophagy preserves the health of cells and tissues by replacing outdated and damaged cellular components with fresh ones. In starvation, it provides an internal source of nutrients for energy generation and, thus, survival. A powerful promoter of metabolic homeostasis at both the cellular and whole-animal level, autophagy prevents degenerative diseases. It does have a downside, however--cancer cells exploit it to survive in nutrient-poor tumors.

Autophagy & Model Organisms

Autophagy is a cellular process that allows degradation by the lysosome of cytoplasmic components such as proteins or organelles. Here is the latest research on autophagy & model organisms

Autophagy Networks

Autophagy is a lysosomal pathway that involves degradation of proteins and functions in normal growth and pathological conditions, through a series of complex networks. The catabolic process involves delivery of proteins and organelles to the lysosome. Here is the latest research on autophagy networks.

Autophagy: Cancer & Parkinson

Autophagy leads to degradation of damaged proteins and organelles by the lysosome. Impaired autophagy has been implicated in several diseases. Here is the role of autophagy in cancer and Parkinson’s.

BCL-2 Family Proteins

BLC-2 family proteins are a group that share the same homologous BH domain. They play many different roles including pro-survival signals, mitochondria-mediated apoptosis and removal or damaged cells. They are often regulated by phosphorylation, affecting their catalytic activity. Here is the latest research on BCL-2 family proteins.

© 2020 Meta ULC. All rights reserved
/feed-previews/dna-repair-in-primary-cell-systems/e5115687-dedc-4683-a51b-d974b34ffefb