DNA Replication Origin

DNA replication is initiated as specific gene sequences, called origins, that function to start DNA replication. Pre-replication complexes are assembled at these origins during the G1 phase of the cell cycle. These sequences allow for targeted activation or deactivation of replication. Discover the latest research on DNA replication origins here.

October 20, 2021
Preprint
Open Access

S-phase induced RNAs initiate formation of DNA replication origins

BioRxiv : the Preprint Server for Biology
S. UmmarinoD. G. Tenen
October 15, 2021
Preprint
Open Access

Speed fluctuations of bacterial replisomes

BioRxiv : the Preprint Server for Biology
D. BhatSimone Pigolotti
October 15, 2021

The adeno-associated virus 2 (AAV2) genome and rep 68/78 proteins interact with cellular sites of DNA damage.

Human Molecular Genetics
Maria BoftsiKinjal Majumder
October 15, 2021

Genomic analysis finds no evidence of canonical eukaryotic DNA processing complexes in a free-living protist.

Nature Communications
Dayana E Salas-LeivaAndrew J Roger
October 12, 2021
Preprint
Open Access

High levels of origin licensing during Xenopus cleavage divisions ensures complete and timely genome duplication

BioRxiv : the Preprint Server for Biology
P. J. GillespieJ. Julian Blow
October 12, 2021
Preprint
Open Access

Dormant replication origin firing links replication stress to whole chromosomal instability in human cancer

BioRxiv : the Preprint Server for Biology
A.-K. SchmidtHolger Bastians
October 11, 2021
Open Access

High-Throughput Genomic Data Reveal Complex Phylogenetic Relationships in Stylosanthes Sw (Leguminosae).

Frontiers in Genetics
Maria Alice Silva OliveiraAndré Marques
October 9, 2021
Review

Preventing excess replication origin activation to ensure genome stability.

Trends in Genetics : TIG
Bhushan L ThakurMirit I Aladjem
October 6, 2021
Preprint
Open Access

A Helicase-tethered ORC Flip Enables Bidirectional Helicase Loading

BioRxiv : the Preprint Server for Biology
S. GuptaStephen P Bell
September 29, 2021
Open Access

Competitive binding of MatP and topoisomerase IV to the MukB hinge domain.

ELife
Gemma Lm FisherDavid J Sherratt
September 29, 2021
Review
Open Access

Biology before the SOS Response-DNA Damage Mechanisms at Chromosome Fragile Sites.

Cells
Devon M Fitzgerald, Susan M Rosenberg
September 27, 2021

Identification and in silico analysis of the origin recognition complex in the human fungal pathogen Candida albicans.

MicroPublication. Biology
Sreedevi PadmanabhanDharanidhar Dubey
September 27, 2021
Review
Open Access

Common Threads: Aphidicolin-Inducible and Folate-Sensitive Fragile Sites in the Human Genome.

Frontiers in Genetics
Rachel Adihe LokangaKaren Usdin
September 27, 2021
Open Access

Spatial Information in the Emergence of Life.

Frontiers in Genetics
Hugo I Cruz-Rosas, Pedro Miramontes
September 24, 2021

Disruption of origin chromatin structure by helicase activation in the absence of DNA replication.

Genes & Development
Rachel A HoffmanDavid M MacAlpine

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