DNA Replication Origin

DNA replication is initiated as specific gene sequences, called origins, that function to start DNA replication. Pre-replication complexes are assembled at these origins during the G1 phase of the cell cycle. These sequences allow for targeted activation or deactivation of replication. Discover the latest research on DNA replication origins here.

July 17, 2020
Open Access

Structural mechanism of helicase loading onto replication origin DNA by ORC-Cdc6

Proceedings of the National Academy of Sciences of the United States of America
Zuanning YuanChristian Speck
March 29, 2020

CNV-BAC: Copy number Variation Detection in Bacterial Circular Genome

Bioinformatics
Linjie WuRuibin Xi
April 9, 2020
Open Access

OZF is a Claspin-interacting protein essential to maintain the replication fork progression rate under replication stress

FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology
Sonia FeuNeus Agell
August 15, 2020
Preprint
Open Access

Human ORC/MCM density is low in active genes and correlates with replication time but does not solely define replication initiation zones

BioRxiv : the Preprint Server for Biology
N. KirsteinAloys Schepers
January 29, 2020
Open Access

Origin Recognition Complex (ORC) Evolution Is Influenced by Global Gene Duplication/Loss Patterns in Eukaryotic Genomes

Genome Biology and Evolution
Eduard Ocaña-PallarèsCrisanto Gutierrez
June 5, 2020

CDC7 kinase promotes MRE11 fork processing, modulating fork speed and chromosomal breakage

EMBO Reports
Michael D RaineyCorrado Santocanale
January 30, 2020
Open Access

Functional and population genetic features of copy number variations in two dairy cattle populations

BMC Genomics
Young-Lim LeeAniek C Bouwman
March 12, 2020
Open Access

An Essential and Cell-Cycle-Dependent ORC Dimerization Cycle Regulates Eukaryotic Chromosomal DNA Replication

Cell Reports
Aftab AminChun Liang
August 28, 2020
Open Access

Structural mechanism for replication origin binding and remodeling by a metazoan origin recognition complex and its co-loader Cdc6

Nature Communications
Jan Marten Schmidt, Franziska Bleichert
June 23, 2020
Open Access

Active transcription and Orc1 drive chromatin association of the AAA+ ATPase Pch2 during meiotic G2/prophase

PLoS Genetics
Richard Cardoso da SilvaGerben Vader
December 24, 2019
Open Access

Origin recognition complex subunit 1 regulates cell growth and metastasis in glioma by altering activation of ERK and JNK signaling pathway

Molecular and Cellular Probes
Wenmin XiongQiaoying Gong
September 10, 2020
Open Access

INO80C Remodeler Maintains Genomic Stability by Preventing Promiscuous Transcription at Replication Origins

Cell Reports
Salih TopalCraig L Peterson
April 19, 2020
Open Access

How to manage travel fatigue and jet lag in athletes? A systematic review of interventions

British Journal of Sports Medicine
Dina C Christa Janse van RensburgTanita Cronje
December 27, 2019

H2A.Z facilitates licensing and activation of early replication origins

Nature
Haizhen LongGuohong Li

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