DNA Vaccine Delivery: Particulates

Biomaterial-based delivery systems based on micro- and nanoparticles that encapsulate plasmid DNA represent the most promising strategy for DNA vaccine delivery. Microparticulate delivery systems allow for passive targeting to antigen presenting cells through size exclusion and can allow for sustained presentation of DNA to cells through degradation and release of encapsulated vaccines. In contrast, nanoparticle encapsulation leads to increased internalization, overall greater transfection efficiency, and the ability to increase uptake across mucosal surfaces. Discover the latest research on DNA vaccine delivery here

January 8, 2021
Open Access

Skin immunization for effective treatment of multifocal melanoma refractory to PD1 blockade and Braf inhibitors

Journal for Immunotherapy of Cancer
Xingxing HaoZhaoyang You
January 14, 2021

COVID-19 vaccine: where are we now and where should we go?

Expert Review of Vaccines
Saman Soleimanpour, Atieh Yaghoubi
December 31, 2020
Review
Open Access

Coiled coil-based therapeutics and drug delivery systems

Advanced Drug Delivery Reviews
Johanna UtterströmDaniel Aili
January 12, 2021

Disulfide Bridging Strategies in Viral and Nonviral Platforms for Nucleic Acid Delivery

Biochemistry
Kingshuk DuttaS Thayumanavan
January 16, 2021

Evaluation of Intranasal Vaccine Delivery Using Anatomical Replicas of Infant Nasal Airways

Pharmaceutical Research
John V WilkinsLillian Li
January 11, 2021

Antiviral activity of Stearylamine against chikungunya virus

Chemistry and Physics of Lipids
Manish Kumar JeengarDeepti Parashar
January 15, 2021

The immunological impact of adenovirus early genes on vaccine-induced responses in mice and nonhuman primates

Journal of Virology
Kotou SangareMichael A Thomas
January 13, 2021
Open Access

In Silico Identification of Potential Druggable Binding Sites on CIN85 SH3 Domain

International Journal of Molecular Sciences
Serena VittorioLaura De Luca
January 6, 2021
Review

Extracellular vesicles derived from mesenchymal stem cells: A platform that can be engineered

Histology and Histopathology
Bo QinKun Xiong
December 31, 2020
Review
Open Access

Advances in Oral Subunit Vaccine Design

Vaccines
Hans Van der WekenBert Devriendt
January 1, 2021
Review
Open Access

Phytopharmaceuticals mediated Furin and TMPRSS2 receptor blocking: can it be a potential therapeutic option for Covid-19?

Phytomedicine : International Journal of Phytotherapy and Phytopharmacology
Partha PalitNima Rezaei
January 6, 2021
Preprint
Open Access

Lipid nanoparticle encapsulated nucleoside-modified mRNA vaccines elicit polyfunctional HIV-1 antibodies comparable to proteins in nonhuman primates

BioRxiv : the Preprint Server for Biology
Kevin O SaundersBarton F Haynes
December 30, 2020
Preprint
Open Access

A novel fermented Yi traditional medicine efficiently suppresses the replication of SARS-CoV-2 in vitro

BioRxiv : the Preprint Server for Biology
S. FangX. Yang
January 15, 2021

Comparing Protein Adsorption onto Alumina and Silica Nanomaterial Surfaces: Clues for Vaccine Adjuvant Development

Langmuir : the ACS Journal of Surfaces and Colloids
Hyeonjin ParkJoshua A Jackman

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