DNA Vaccine Delivery: Particulates

Biomaterial-based delivery systems based on micro- and nanoparticles that encapsulate plasmid DNA represent the most promising strategy for DNA vaccine delivery. Microparticulate delivery systems allow for passive targeting to antigen presenting cells through size exclusion and can allow for sustained presentation of DNA to cells through degradation and release of encapsulated vaccines. In contrast, nanoparticle encapsulation leads to increased internalization, overall greater transfection efficiency, and the ability to increase uptake across mucosal surfaces. Discover the latest research on DNA vaccine delivery here

April 30, 2020
PreprintOpen Access

Spike mutation pipeline reveals the emergence of a more transmissible form of SARS-CoV-2

bioRxiv
Bette KorberDavid Montefiori
May 22, 2020
Open Access

Robust antibody and cellular responses induced by DNA-only vaccination for HIV

JCI Insight
Stephen DeRosaM Juliana McElrath
May 3, 2020

CARD9-Associated Dectin-1 and Dectin-2 Are Required for Protective Immunity of a Multivalent Vaccine against Coccidioides posadasii Infection

The Journal of Immunology : Official Journal of the American Association of Immunologists
Althea CampuzanoChiung-Yu Hung
May 13, 2020
Open Access

Aluminum Nanoparticles Acting as a Pulmonary Vaccine Adjuvant-Delivery System (VADS) Able to Safely Elicit Robust Systemic and Mucosal Immunity

Journal of Inorganic and Organometallic Polymers and Materials
Ning WangTing Wang
May 5, 2020
Open Access

Rapid reconstruction of SARS-CoV-2 using a synthetic genomics platform

Nature
Tran Thi Nhu ThaoVolker Thiel
May 20, 2020
Open Access

Characterisation of alternative expression vectors for recombinant Bacillus Calmette-Guérin as live bacterial delivery systems

Memórias do Instituto Oswaldo Cruz
Larissa V NascimentoIvan P Nascimento
April 26, 2020

Screening for protective antigens of Cyprinid herpesvirus 2 and construction of DNA vaccines

Journal of Virological Methods
Xuemei YuanLi Liu
May 27, 2020
Open Access

DNA Vaccine Treatment in Dogs Experimentally Infected with Trypanosoma cruzi

Journal of Immunology Research
Minerva Arce-FonsecaOlivia Rodríguez-Morales
May 31, 2020
Review

Pulmonary Delivery of Fenretinide: A Possible Adjuvant Treatment In COVID-19

International Journal of Molecular Sciences
Isabella OrientiGiovanna Farruggia
May 10, 2020
Open Access

Innate Molecular and Cellular Signature in the Skin Preceding Long-Lasting T Cell Responses after Electroporated DNA Vaccination

The Journal of Immunology : Official Journal of the American Association of Immunologists
Lucille AdamFrédéric Martinon
April 30, 2020
Review

Exosomes: From garbage bins to translational medicine

International Journal of Pharmaceutics
Ying LiuXiaoyu Li

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