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Down Syndrome

Down Syndrome diagram by Kateryna Kon, Shutterstock
Kateryna Kon, Shutterstock

Down syndrome is a chromosome disorder associated either with an extra chromosome 21 or an effective trisomy for chromosome 21. Clinical manifestations include hypotonia, short stature, brachycephaly, upslanting palpebral fissures, epicanthus, Brushfield spots on the iris, protruding tongue, small ears, short, broad hands, fifth finger clinodactyly, Simian crease, and moderate to severe intellectual disability. Discover the latest research on Down syndrome here.

Top 20 most recent papers
Proceedings of the National Academy of Sciences of the United States of America

Integrated functional genomic analyses of Klinefelter and Turner syndromes reveal global network effects of altered X chromosome dosage

Proceedings of the National Academy of Sciences of the United States of AmericaFebruary 20, 2020
Xianglong ZhangAlexander E Urban

Currently Unstable: Daily Ups and Downs in E-I Balance

NeuronFebruary 21, 2020
Samuel J Brunwasser, Keith B Hengen
Arteriosclerosis, Thrombosis, and Vascular Biology

Novel Long Noncoding RNA, Macrophage Inflammation-Suppressing Transcript (MIST ), Regulates Macrophage Activation During Obesity

Arteriosclerosis, Thrombosis, and Vascular BiologyFebruary 21, 2020
Kenneth StapletonRama Natarajan
Annals of the American Thoracic Society

Driving Pressure-Limited Strategy for Patients with Acute Respiratory Distress Syndrome (ARDS): A Pilot Randomized Clinical Trial

Annals of the American Thoracic SocietyFebruary 19, 2020
Marcelo Luz Pereira RomanoAlexandre Biasi Cavalcanti
Perspectives in Biology and Medicine

Who's Afraid of the Big Bad (Germline Editing) Wolf?

Perspectives in Biology and MedicineFebruary 18, 2020
R Alta Charo
Therapeutic Innovation & Regulatory Science

Disease Modification in Alzheimer's Disease: Current Thinking

Therapeutic Innovation & Regulatory ScienceFebruary 20, 2020
Hong Liu-SeifertRichard Entsuah
Journal of Vascular and Interventional Neurology

A New Method for Assessment of Upright Posture Intolerance

Journal of Vascular and Interventional NeurologyFebruary 20, 2020
Adnan I Qureshi
Journal of Translational Medicine

Suppression of p66Shc prevents hyperandrogenism-induced ovarian oxidative stress and fibrosis

Journal of Translational MedicineFebruary 19, 2020
Daojuan WangYong Wang
Molecular and Cellular Endocrinology

Downregulation of Lnc-OC1 attenuates the pathogenesis of polycystic ovary syndrome

Molecular and Cellular EndocrinologyFebruary 20, 2020
Gengxiang WuTailang Yin
Journal of Pediatric Hematology/oncology

Acute Megakaryoblastic Leukemia Leading to the Diagnosis of Germline Trisomy 21 Mosaicism

Journal of Pediatric Hematology/oncologyFebruary 19, 2020
Dipal SavlaDennis John Kuo

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