Drug Efflux Transporters

Drug efflux transporters, such as P-glycoprotein (Pgp), multidrug resistance proteins (MRPs) or organic anion transporting polypeptides (OATPs), transport drug molecules out of the cells. Discover the latest research on drug efflux transporters here.

September 20, 2020

Autophagy Inhibition Enables Nrf2 to Exaggerate the Progression of Diabetic Cardiomyopathy in Mice

Huimei ZangTaixing Cui
September 24, 2020

A "Drug Sweeping" State of the TriABC Triclosan Efflux Pump from Pseudomonas aeruginosa

Lucien FabreJurgen Sygusch
September 25, 2020

Thrombin-Par1 signaling axis disrupts COP9 signalosome subunit 3-mediated ABCA1 stabilization in inducing foam cell formation and atherogenesis

Cell Death and Differentiation
Monoranjan BoroGadiparthi N Rao
September 19, 2020
Open Access

A two-tiered in vitro approach to de-risk drug candidates for potential bile salt export pump inhibition liabilities in drug discovery

Drug Metabolism and Disposition : the Biological Fate of Chemicals
Michael J HafeyRaymond Evers
September 19, 2020

Zinc dysregulation in cancers and its potential as a therapeutic target

Cancer Biology & Medicine
Jie WangXinxin Cheng
September 22, 2020

Transcriptome analysis of Plantago major as a phytoremediator to identify some genes related to cypermethrin detoxification

Environmental Science and Pollution Research International
Ahmed A A AioubZhaonong Hu
September 24, 2020
Open Access

TL1A inhibits atherosclerosis in apoE-deficient mice by regulating the phenotype of vascular smooth muscle cells

The Journal of Biological Chemistry
Dan ZhaoXiaoxiao Yang
September 26, 2020

Cyclic AMP efflux through MRP4 regulates actin dynamics signalling pathway and sperm motility in bovines

Scientific Reports
Nicolás ChiaranteSilvina Perez-Martinez
September 26, 2020
Open Access

Resistance to Bipyridyls Mediated by the TtgABC Efflux System in Pseudomonas putida KT2440

Frontiers in Microbiology
Tania HenríquezHeinrich Jung
September 26, 2020
Open Access

Consequences of CRISPR-Cas9-Mediated CFTR Knockout in Human Macrophages

Frontiers in Immunology
Shuzhong ZhangBenjamin T Kopp
September 24, 2020
Open Access

Amidochelocardin Overcomes Resistance Mechanisms Exerted on Tetracyclines and Natural Chelocardin

Fabienne HennessenRolf Müller
September 23, 2020
Open Access

Resistance against membrane-inserting MmpL3 inhibitor through upregulation of MmpL5 in M. tuberculosis

Antimicrobial Agents and Chemotherapy
Ming LiThomas Dick
September 26, 2020
Open Access

Nanoparticle-Based Drug Delivery in Cancer Therapy and Its Role in Overcoming Drug Resistance

Frontiers in Molecular Biosciences
Yihan YaoAnwen Shao
September 26, 2020

Calcium ATPase signaling: A must include mechanism in the Radar of therapeutics development against Tuberculosis

Biotechnology and Applied Biochemistry
Shivangi, Laxman S Meena
September 20, 2020

Potassium Efflux and Cytosol Acidification as Primary Anoxia-Induced Events in Wheat and Rice Seedlings

Vladislav V YemelyanovSylvia M Lindberg

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