Drug-Inactivating Enzymes & Resistance

Drug inactivation or modification is one of the mechanisms through which resistance occurs. For instance, some penicillin-resistant bacteria produce beta-lactamases to enzymatically deactivate Penicillin G. Here is the latest research on drug inactivating enzymes and resistance.

September 19, 2020

Dissecting the antibacterial activity of oxadiazolone-core derivatives against Mycobacterium abscessus

PloS One
Abdeldjalil MadaniJean François Cavalier
September 23, 2020
Review

Recent progress on HDAC inhibitors with dual targeting capabilities for cancer treatment

European Journal of Medicinal Chemistry
Xiaopeng PengJianjun Chen
September 17, 2020

A Comparative Genomics Approach for Shortlisting Broad-Spectrum Drug Targets in Nontuberculous Mycobacteria

Microbial Drug Resistance : MDR : Mechanisms, Epidemiology, and Disease
Aishwarya SwainArchana Pan
September 19, 2020

Prevalence of OXA-type class D β-lactamases among clinical isolates of Klebsiella pneumoniae in multiple centers in Tehran, Iran

Infectious Disorders Drug Targets
Pariya MehrbakhshShahin Bolori
September 19, 2020

Evolutionary insights into the active-site structures of the metallo-β-lactamase superfamily from a classification study with support vector machine

Journal of Biological Inorganic Chemistry : JBIC : a Publication of the Society of Biological Inorganic Chemistry
Lili WangHao Zhang
September 19, 2020

Analysis of pathogens and clinical characteristics of bloodstream infection in neutropenic children with hematological malignancies from 2014 to 2018

Zhonghua xue ye xue za zhi = Zhonghua xueyexue zazhi
G Q ZhuY M Chen
September 19, 2020

Determination of Extent of PEGylation using Denaturing Capillary Isoelectric Focussing

Analytical Biochemistry
Thomas C MinshullDavid Gervais
September 23, 2020

Organoarsenicals inhibit bacterial peptidoglycan biosynthesis by targeting the essential enzyme MurA

Chemosphere
Luis D GarbinskiMasafumi Yoshinaga
September 19, 2020

Wnt/β-catenin signaling pathway induces autophagy-mediated temozolomide-resistance in human glioblastoma

Cell Death & Disease
Eun-Jin YunSeung Tae Baek
September 22, 2020

Cloning of the soybean E2 ubiquitin-conjugating enzyme GmUBC1 and its expression in Arabidopsis thaliana

Yi chuan = Hereditas
Zhuo Zhuo MaoFang Huang
September 17, 2020

4-Amino-1,2,4-triazole-3-thione-derived Schiff bases as metallo-β-lactamase inhibitors

European Journal of Medicinal Chemistry
Laurent GavaraJean-François Hernandez
September 20, 2020

Anticancer Properties of Platinum Nanoparticles and Retinoic Acid: Combination Therapy for the Treatment of Human Neuroblastoma Cancer

International Journal of Molecular Sciences
Sangiliyandi GurunathanJin-Hoi Kim
September 22, 2020

Improve Production of Pullulanase of Bacillus subtilis in Batch and Fed-Batch Cultures

Applied Biochemistry and Biotechnology
Fanqiang MengZhaoxin Lu

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