Drug-Inactivating Enzymes & Resistance

Drug inactivation or modification is one of the mechanisms through which resistance occurs. For instance, some penicillin-resistant bacteria produce beta-lactamases to enzymatically deactivate Penicillin G. Here is the latest research on drug inactivating enzymes and resistance.

October 20, 2021
Preprint
Open Access

Characterization of adenine phosphoribosyltransferase (APRT) activity in Trypanosoma brucei brucei: only one of the two isoforms is kinetically active

BioRxiv : the Preprint Server for Biology
K. GlockzinArdala E. Katzfuss
October 20, 2021
Preprint
Open Access

Pseudomonas aeruginosa cytochrome P450 CYP168A1 is a fatty acid hydroxylase that metabolizes arachidonic acid to the vasodilator 19-HETE

BioRxiv : the Preprint Server for Biology
B. C. TookerJed Noah Lampe
October 17, 2021

Musarin, a novel protein with tyrosine kinase inhibitory activity from Trametes versicolor, accepted inhibits colorectal cancer stem cell growth.

Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie
YingYing HeDavid S Newburg
October 15, 2021
Review

Penetration of Antibacterial Agents into Pulmonary Epithelial Lining Fluid: An Update.

Clinical Pharmacokinetics
Emily N Drwiega, Keith A Rodvold
October 15, 2021
Open Access

Using Molecular Diagnostics to Develop Therapeutic Strategies for Carbapenem-Resistant Gram-Negative Infections.

Frontiers in Cellular and Infection Microbiology
Fred C Tenover
October 15, 2021
Open Access

Predicting drug targets by homology modelling of Pseudomonas aeruginosa proteins of unknown function.

PloS One
Nikolina Babic, Filip Kovacic
October 14, 2021
Preprint
Open Access

A monoclonal antibody that neutralizes SARS-CoV-2 variants, SARS-CoV, and other sarbecoviruses

BioRxiv : the Preprint Server for Biology
P. WangDavid D Ho
October 15, 2021
Review

Contemporary Perspective on the Treatment of Acinetobacter baumannii Infections: Insights from the Society of Infectious Diseases Pharmacists.

Infectious Diseases and Therapy
Jacinda C Abdul-MutakabbirZahra Kassamali Escobar
October 15, 2021

The unfolding role of ceramide in coordinating retinoid-based cancer therapy.

The Biochemical Journal
Botheina GhandourNadine Darwiche
October 15, 2021

Draft Genome Sequence of NDM-Encoding Klebsiella pneumoniae Isolated from Feral Swine.

Microbiology Resource Announcements
Huijia LiuKwangcheol C Jeong
October 15, 2021

QM/MM modeling of class A β-lactamases reveals distinct acylation pathways for ampicillin and cefalexin.

Organic & Biomolecular Chemistry
Zilin SongPeng Tao
October 15, 2021
Open Access

Upregulation of Thymidylate Synthase Induces Pemetrexed Resistance in Malignant Pleural Mesothelioma.

Frontiers in Pharmacology
Yuzo SatoHideki Makinoshima
October 14, 2021
Open Access

Microbial colonization and resistome dynamics in food processing environments of a newly opened pork cutting industry during 1.5 years of activity.

Microbiome
José F Cobo-DíazAvelino Alvarez-Ordóñez

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