Enhancer Activation & Histones (Keystone)

Enhancers are short regions of the DNA which can be bound by activator or repressor proteins to affect transcription of a particular gene. Here is the latest research on mechanisms of enhancer activation using the histone variant H3.

September 1, 2017
Open Access

Epigenome-wide analysis of DNA methylation in lung tissue shows concordance with blood studies and identifies tobacco smoke-inducible enhancers

Human Molecular Genetics
Theresa Ryan StueveMaria Teresa Landi
September 20, 2017
Open Access

NCoR1-independent mechanism plays a role in the action of the unliganded thyroid hormone receptor

Proceedings of the National Academy of Sciences of the United States of America
Arturo MendozaAnthony N Hollenberg
April 16, 2018
Open Access

H3.3K4M destabilizes enhancer epigenomic writers MLL3/4 and impairs adipose tissue development

BioRxiv : the Preprint Server for Biology
Younghoon JangKai Ge
September 13, 2017
Open Access

VHL Deficiency Drives Enhancer Activation of Oncogenes in Clear Cell Renal Cell Carcinoma

Cancer Discovery
Xiaosai YaoPatrick Tan
July 4, 2017

Histone H3 lysine 4 methyltransferase KMT2D

Eugene FroimchukKai Ge
May 12, 2018

Hey1- and p53-dependent TrkC proapoptotic activity controls neuroblastoma growth

PLoS Biology
Marie MénardServane Tauszig-Delamasure
April 26, 2020
Open Access

Darolutamide antagonizes androgen signaling by blocking enhancer and super-enhancer activation

Molecular Oncology
Simon J BaumgartBernard Haendler
January 31, 2018

Widespread transcriptional pausing and elongation control at enhancers

Genes & Development
Telmo HenriquesKaren Adelman
September 21, 2019

Enhancer activation by FGF signalling during otic induction

Developmental Biology
Monica TambaloAndrea Streit
August 22, 2018

Smchd1 regulates long-range chromatin interactions on the inactive X chromosome and at Hox clusters

Nature Structural & Molecular Biology
Natasha JanszMarnie E Blewitt
June 30, 2018
Open Access

Mutant p53 regulates enhancer-associated H3K4 monomethylation through interactions with the methyltransferase MLL4

The Journal of Biological Chemistry
Homa RahnamounShannon M Lauberth
January 3, 2018
Open Access

EZH2 Impairs Human Dental Pulp Cell Mineralization via the Wnt/β-Catenin Pathway

Journal of Dental Research
B LiL Ye

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