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Enzyme Evolution
Šmíd et al, PLOS PathogensThis feed focuses on molecular models of enzyme evolution and new approaches (such as adaptive laboratory evolution) to metabolic engineering of microorganisms. Here is the latest research.
Top 20 most recent papers
Adaptive evolution reveals a tradeoff between growth rate and oxidative stress during naphthoquinone-based aerobic respiration
Proceedings of the National Academy of Sciences of the United States of AmericaNovember 27, 2019
Amitesh AnandBernhard O Palsson
25
3
Cellular responses to reactive oxygen species are predicted from molecular mechanisms
Proceedings of the National Academy of Sciences of the United States of AmericaJuly 5, 2019
Laurence YangBernhard O Palsson
10
51
Systems-level analysis of NalD mutation, a recurrent driver of rapid drug resistance in acute Pseudomonas aeruginosa infection
PLoS Computational BiologyDecember 21, 2019
Jinyuan YanJoao B Xavier
4
MEMOTE for standardized genome-scale metabolic model testing
Nature BiotechnologyMarch 4, 2020
Christian LievenCheng Zhang
137
3
1
Genetic Determinants Enabling Medium-Dependent Adaptation to Nafcillin in Methicillin-Resistant Staphylococcus aureus
MSystemsApril 3, 2020
Michael J SalazarAdam M Feist
BiGG Models 2020: multi-strain genome-scale models and expansion across the phylogenetic tree
Nucleic Acids ResearchNovember 7, 2019
Charles J NorsigianZachary King
12
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The emergence of adaptive laboratory evolution as an efficient tool for biological discovery and industrial biotechnology
Metabolic EngineeringAugust 12, 2019
Troy E SandbergAdam M Feist
12
1
117
Revealing 29 sets of independently modulated genes in Staphylococcus aureus, their regulators and role in key physiological responses
bioRxivMarch 20, 2020
Saugat PoudelBernhard O Palsson
4
Profiling the effect of nafcillin on HA-MRSA D712 using bacteriological and physiological media
Scientific DataDecember 19, 2019
Akanksha RajputJoe Pogliano
11
A workflow for generating multi-strain genome-scale metabolic models of prokaryotes
Nature ProtocolsDecember 22, 2019
Charles J NorsigianBernhard O Palsson
86
Systems-level physiology of the human red blood cell is computed from metabolic and macromolecular mechanisms
bioRxivOctober 8, 2019
James T YurkovichBernhard O Palsson
5
4
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Strain-Specific Metabolic Requirements Revealed by a Defined Minimal Medium for Systems Analyses of Staphylococcus aureus
Applied and Environmental MicrobiologySeptember 1, 2019
Henrique MachadoAdam M Feist
2
18
Prokaryotic Genome Expansion Is Facilitated by Phages and Plasmids but Impaired by CRISPR
Frontiers in MicrobiologyNovember 5, 2019
Na L GaoWei-Hua Chen
7
8
474
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2
Iron competition triggers antibiotic biosynthesis in Streptomyces coelicolor during coculture with Myxococcus xanthus
The ISME JournalJanuary 30, 2020
Namil LeeByung-Kwan Cho
25
Machine learning with random subspace ensembles identifies antimicrobial resistance determinants from pan-genomes of three pathogens
PLoS Computational BiologyMarch 3, 2020
Jason C HyunBernhard O Palsson
19
Thirty complete Streptomyces genome sequences for mining novel secondary metabolite biosynthetic gene clusters
Scientific DataFebruary 15, 2020
Namil LeeByung-Kwan Cho
STATR: A simple analysis pipeline of Ribo-Seq in bacteria
The Journal of MicrobiologyJanuary 29, 2020
Donghui ChoeByung-Kwan Cho
7