Epigenetics of Beta Cells in T2D

While type 2 diabetes (T2D) is heritable, less than 20% of this heritability is explained by known genetic variants. This discrepancy maybe explained by epigenetic changes and epigenetic inheritance in pancreatic cells. Here is the latest research on the epigenetic control of beta cell function and failure in T2D.

January 20, 2021

ATP-sensitive potassium channel subunits in the neuroinflammation: novel drug targets in neurodegenerative disorders

CNS & Neurological Disorders Drug Targets
Fatima MaqoudDomenico Tricarico
January 21, 2021

Embryonic Exposure to Low Concentrations of Bisphenol A and S Altered Genes Related to Pancreatic β-Cell Development and DNA Methyltransferase in Zebrafish.

Archives of Environmental Contamination and Toxicology
Eric GyimahJohn Kenneth Mensah
January 23, 2021
Open Access

The Mutation Spectrum of Maturity Onset Diabetes of the Young (MODY)-Associated Genes among Western Siberia Patients.

Journal of Personalized Medicine
Dinara E IvanoshchukMikhail I Voevoda
January 21, 2021
Review
Open Access

New Insights Into the Role of Autoreactive CD8 T Cells and Cytokines in Human Type 1 Diabetes.

Frontiers in Endocrinology
Christine BenderMatthias G von Herrath
January 19, 2021

Melatonin regulates maternal pancreatic remodeling and Β-cell function during pregnancy and lactation

Journal of Pineal Research
Patricia Rodrigues Lourenço GomesJosé Cipolla Neto
January 22, 2021

Changes in early intestinal flora and Type 1 diabetes.

Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences
Qin Zhang, Ping Jin
January 19, 2021
Review
Open Access

Nutrient Sensor mTOR and OGT: Orchestrators of Organelle Homeostasis in Pancreatic β -Cells

Journal of Diabetes Research
Nicholas EschEmilyn U Alejandro
January 20, 2021

Insulin sensitivity and pancreatic β-cell function in patients with primary aldosteronism

Endocrine
Shivraj GrewalRanganath Muniyappa
January 24, 2021

De-coding genetic risk variants in type 1 diabetes.

Immunology and Cell Biology
Melanie R ShapiroTodd M Brusko
January 21, 2021
Preprint
Open Access

Transcriptome Analysis of the Transdifferentiation of canine BMSCs into Insulin Producing Cells

ResearchSquare
JINGLU WANGYihua Zhang
January 18, 2021

Effects of sustained GABA releasing implants on pancreatic islets in mice

Drug Delivery and Translational Research
Kevin C LingEdward A Phelps
January 19, 2021
Review
Open Access

The many lives of Myc in the pancreatic β-cell.

The Journal of Biological Chemistry
Carolina RosselotDonald K Scott
January 21, 2021

Dynamic uni- and Multicellular Patterns Encode Biphasic Activity in Pancreatic Islets.

Diabetes
Manon JaffredoMatthieu Raoux
January 24, 2021
Open Access

Free fatty-acid receptor 4 inhibitory signaling in delta cells regulates islet hormone secretion in mice.

Molecular Metabolism
Marine L CrozeVincent Poitout
January 23, 2021

The neuropeptide allatostatin C from clock-associated DN1p neurons generates the circadian rhythm for oogenesis.

Proceedings of the National Academy of Sciences of the United States of America
Chen ZhangYoung-Joon Kim

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