Epigenetics of Beta Cells in T2D

While type 2 diabetes (T2D) is heritable, less than 20% of this heritability is explained by known genetic variants. This discrepancy maybe explained by epigenetic changes and epigenetic inheritance in pancreatic cells. Here is the latest research on the epigenetic control of beta cell function and failure in T2D.

January 16, 2022

A pro-endocrine pancreatic islet transcriptional program established during development is retained in human gallbladder epithelial cells.

Cellular and Molecular Gastroenterology and Hepatology
Mugdha V JoglekarAnandwardhan A Hardikar
January 15, 2022
Open Access

Genome-wide Analysis Reflects Novel 5-Hydroxymethylcytosines Implicated in Diabetic Nephropathy

MedRxiv : the Preprint Server for Health Sciences
Y. YangSong-Mei Liu
January 14, 2022
Open Access

Paternally expressed gene 3 (Pw1/Peg3) promotes sexual dimorphism in metabolism and behavior.

PLoS Genetics
Karo TanakaDavid A Sassoon
January 14, 2022

Deconstructing a Syndrome: Genomic Insights into PCOS Causal Mechanisms and Classification.

Endocrine Reviews
Matthew Dapas, Andrea Dunaif
January 13, 2022

Mapping the cord blood transcriptome of pregnancies affected by early maternal anemia to identify signatures of fetal programming.

The Journal of Clinical Endocrinology and Metabolism
Gad HatemRashmi B Prasad
January 12, 2022
Open Access

Lipid-Induced Adaptations of the Pancreatic Beta-Cell to Glucotoxic Conditions Sustain Insulin Secretion.

International Journal of Molecular Sciences
Lucie Oberhauser, Pierre Maechler
January 12, 2022
Open Access

Genome-wide DNA methylation profiling in anorexia nervosa discordant identical twins.

Translational Psychiatry
C Iranzo-TatayL Rojo-Moreno
January 11, 2022
Open Access

The Glucagon-Like Adipokinetic Hormone in Drosophila melanogaster - Biosynthesis and Secretion.

Frontiers in Physiology
Bryon N Hughson
January 11, 2022
Open Access

Research Progress on Epigenetics of Diabetic Cardiomyopathy in Type 2 Diabetes.

Frontiers in Cell and Developmental Biology
Jianxin DengDewen Yan
January 7, 2022

The correlation between amylin and insulin by treatment with 2-deoxy-D-glucose and/or mannose in rat insulinoma ins-1E cells.

Journal of Physiology and Pharmacology : an Official Journal of the Polish Physiological Society
H S KimY-M Yoo
January 6, 2022

Epigenetic modifications in pancreas development, diabetes, and therapeutics.

Medicinal Research Reviews
Suneesh KaimalaBright Starling Emerald
January 4, 2022

Differentiation of Human Pluripotent Stem Cells into Pancreatic Beta-cell Precursors in a 2D Culture System.

Journal of Visualized Experiments : JoVE
Bushra Memon, Essam M Abdelalim
January 4, 2022
Open Access

Molecular Mechanisms and Epigenetic Regulation in Diabetic Cardiomyopathy.

Frontiers in Cardiovascular Medicine
Anupam MittalMadhu Khullar
December 28, 2021

The molecular link between oxidative stress, insulin resistance, and type 2 diabetes: A target for new therapies against cardiovascular diseases.

Current Opinion in Pharmacology
Aikaterini AndreadiDavide Lauro
December 25, 2021
Open Access

The HDAC Inhibitor Butyrate Impairs β Cell Function and Activates the Disallowed Gene Hexokinase I.

International Journal of Molecular Sciences
Stephanie BridgemanCyril Mamotte

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