Epigenetics of Myotonic Dystrophy

Myotonic Dystrophy is an autosomal dominant neuromuscular disorder associated with the expansion of CTG trinucleotide repeats in the 3’ untranslated region of the myotonic dystrophy protein kinase (DMPK) gene. Here is the latest research focusing on epigenetic modifications in myotonic dystrophy.

July 11, 2020
Open Access

The Need for Establishing a Universal CTG Sizing Method in Myotonic Dystrophy Type 1

Genes
Alfonsina Ballester-LopezGisela Nogales-Gadea
June 7, 2020

Overexpression of Staufen1 in DM1 mouse skeletal muscle exacerbates dystrophic and atrophic features

Human Molecular Genetics
Tara E Crawford ParksAymeric Ravel-Chapuis
July 9, 2020

Unexpected Mutations by CRISPR-Cas9 CTG Repeat Excision in Myotonic Dystrophy and Use of CRISPR Interference as an Alternative Approach

Molecular Therapy. Methods & Clinical Development
Miki IkedaFumiaki Saito
May 7, 2020

Regulation of taurine in OTA-induced apoptosis and autophagy

Toxicon : Official Journal of the International Society on Toxinology
Kai LiuXingxiang Chen
April 17, 2020
Open Access

Consensus-Based Care Recommendations for Pulmonologists Treating Adults with Myotonic Dystrophy Type 1

Respiration; International Review of Thoracic Diseases
Matthias BoentertValeria A Sansone
March 17, 2020
Open Access

MERTK is a host factor that promotes classical swine fever virus entry and antagonizes innate immune response in PK-15 cells

Emerging Microbes & Infections
Guanglai ZhengHua-Ji Qiu
March 24, 2020

Parental repeat length instability in myotonic dystrophy type 1 pre- and protomutations

European Journal of Human Genetics : EJHG
Isis B T JoostenMonique M Gerrits
May 15, 2020
Open Access

A Fully Integrated Assay Panel for Early Drug Metabolism and Pharmacokinetics Profiling

Assay and Drug Development Technologies
Johan WernevikThomas Lundbäck
June 20, 2020

Discovery of RO7185876, a Highly Potent γ-Secretase Modulator (GSM) as a Potential Treatment for Alzheimer's Disease

ACS Medicinal Chemistry Letters
Hasane RatniKarlheinz Baumann
July 11, 2020

Macrocyclization of a ligand targeting a toxic RNA dramatically improves potency

Chembiochem : a European Journal of Chemical Biology
Raphael BenhamouMatthew D Disney
March 14, 2020

Further considerations towards an effective and efficient oncology drug discovery DMPK strategy

Current Drug Metabolism
Beth WilliamsonDermot McGinnity
June 26, 2020
Open Access

MG132 Attenuates the Replication of Classical Swine Fever Virus in vitro

Frontiers in Microbiology
Yuming ChenJinding Chen
June 21, 2020
Open Access

Identification of lncRNAs Involved in PCV2 Infection of PK-15 Cells

Pathogens
Jin HeHuanan Wang
March 18, 2020

Aminobenzosuberone derivatives as PfA-M1 inhibitors: Molecular recognition and antiplasmodial evaluation

Bioorganic Chemistry
Emmanuel SalomonSébastien Albrecht
July 6, 2020

Cytoprotective effects of curcumin and silymarin on PK-15 cells exposed to ochratoxin A, fumonisin B1 and deoxynivalenol

Toxicon : Official Journal of the International Society on Toxinology
Pauline Christ Ledur, Janio M Santurio

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