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European Bioinformatics Institute

European Bioinformatics Institute diagram by Stoeger et al, PLOS Biology
Stoeger et al, PLOS Biology

European Bioinformatics Institute focuses both on data resource development and investigator-driven research in the field of bioinformatics. Follow this feed to stay up to date on research by this institute.

Top 20 most recent papers
The Journal of Biological Chemistry

A global analysis of function and conservation of catalytic residues in enzymes

The Journal of Biological ChemistryDecember 5, 2019
Antonio J M RibeiroJanet M Thornton

The evolutionary history of 2,658 cancers

NatureFebruary 7, 2020
Moritz GerstungPCAWG Consortium
Proceedings of the National Academy of Sciences of the United States of America

Defining the remarkable structural malleability of a bacterial surface protein Rib domain implicated in infection

Proceedings of the National Academy of Sciences of the United States of AmericaDecember 11, 2019
Fiona WhelanJennifer R Potts

Genomic basis for RNA alterations in cancer

NatureFebruary 7, 2020
PCAWG Transcriptome Core GroupPCAWG Consortium
Genome Biology

Eleven grand challenges in single-cell data science

Genome BiologyFebruary 9, 2020
David LähnemannAlexander Schönhuth
Journal of Chemical Information and Modeling

Hotspots API: A Python Package for the Detection of Small Molecule Binding Hotspots and Application to Structure-Based Drug Design

Journal of Chemical Information and ModelingMarch 26, 2020
Peter Richard CurranJason C Cole

Genomic copy number predicts oesophageal cancer years before transformation

bioRxivFebruary 28, 2020
Sarah KillcoyneRebecca C Fitzgerald
Acta Crystallographica. Section D, Structural Biology

The thrombospondin module 1 domain of the matricellular protein CCN3 shows an atypical disulfide pattern and incomplete CWR layers

Acta Crystallographica. Section D, Structural BiologyFebruary 11, 2020
Emma Ruoqi XuMarko Hyvönen

The single-cell eQTLGen consortium

ELifeMarch 10, 2020
Monique Gp van der WijstLude Franke

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Human Vascular Endothelial Cell Atlas: Young & Old

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Telomere Dysfunction

Telomere dysfunction in response to critical telomere shortening induces dna damage checkpoints that lead to cell cycle arrest and/or cell death.

Incretin & Type 1 Diabetes

Incretins are metabolic hormones that stimulate a decrease in glucose levels in the blood and they have been implicated in glycemic regulation in the remission phase of type 1 diabetes. Here is the latest research.

Allen Institute for Brain Science Network (MDS)

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Severe Acute Respiratory Syndrome

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Computation Neuroscience - Preprints (MDS)

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LRRK2 & Immunity During Infection (MDS)

Mutations in the LRRK2 gene are a risk-factor for developing Parkinson’s disease. However, LRRK2 has been shown to function as a central regulator of vesicular trafficking, infection, immunity, and inflammation. Here is the latest research on the role of this kinase on immunity during infection.

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