FoxO Signaling in Aging

Forkheadbox-O (FoxO) family of transcription factors are downstream of insulin signaling and are involved in longevity and aging. Discover the latest research on FoxO Signaling in Aging here.

January 15, 2022

Effect of FOXO3 and Air Pollution on Cognitive Function: A Longitudinal Cohort Study of Older Adults in China from 2000 to 2014.

The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences
John S JiLijing Yan
December 27, 2021

Biophysical investigation of the dual binding surfaces of human transcription factors FOXO4 and p53.

The FEBS Journal
Jinwoo KimChin-Ju Park
December 25, 2021
Open Access

Differential Dose- and Tissue-Dependent Effects of foxo on Aging, Metabolic and Proteostatic Pathways.

Cells
Maria S ManolaIoannis P Trougakos
December 25, 2021
Open Access

Association of FOXO3 Blood DNA Methylation with Cancer Risk, Cancer Survival, and Mortality.

Cells
Chenglong YuPierre-Antoine Dugué
December 21, 2021

Sex Difference and Interaction of SIRT1 and FOXO3 Candidate Longevity Genes on Life Expectancy: A 10-year Prospective Longitudinal Cohort Study.

The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences
John S JiYi Zeng
December 8, 2021

Comparing Effects of FOXO3A and Residing in Urban Areas on Longevity: A Gene-Environment Interaction Study.

The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences
John S JiYi Zeng
November 17, 2021

Impact of FOXP1 rs2687201 genetic variant on the susceptibility to HCV-related hepatocellular carcinoma in Egyptians.

Journal of Biochemical and Molecular Toxicology
Tarek Mohamed Kamal MotawiAtef Tadros Fahim
October 26, 2021
Preprint
Open Access

Uterine-specific SIRT1 deficiency confers premature uterine aging and impairs invasion and spacing of blastocyst and stromal cell decidualization in mice.

BioRxiv : the Preprint Server for Biology
M. J. CummingsXiaoqiu Wang
October 20, 2021
Preprint
Open Access

Uncovering the Genetic Architecture of Broad Antisocial Behavior through a Genome-Wide Association Study Meta-analysis.

BioRxiv : the Preprint Server for Biology
Jorim J Tielbeek Dionne
October 14, 2021
Preprint
Open Access

Investigating the Role of Chromatin Remodeler FOXA1 in Ferroptotic Cell Death

BioRxiv : the Preprint Server for Biology
E. LogieWim Vanden Berghe
October 6, 2021
Review

FOXOs: masters of the equilibrium.

The FEBS Journal
Tianshu Gui, Boudewijn M T Burgering
August 26, 2021

Extreme longevity variants at the FOXO3 locus may moderate FOXO3 isoform levels.

GeroScience
Ryan FrankumLorna W Harries
August 24, 2021

Identification of a KLF5-dependent program and drug development for skeletal muscle atrophy.

Proceedings of the National Academy of Sciences of the United States of America
Lin LiuYumiko Oishi
August 23, 2021

TGFβ1 signaling protects chondrocytes against oxidative stress via FOXO1-autophagy axis.

Osteoarthritis and Cartilage
I KurakazuY Nakashima
August 17, 2021
Review

FOXO and related transcription factors binding elements in the regulation of neurodegenerative disorders.

Journal of Chemical Neuroanatomy
Vaibhav OliPravir Kumar
August 15, 2021
Review

p21-Activated kinase 1 (PAK1) in aging and longevity: An overview.

Ageing Research Reviews
Mohankumar AmirthalingamShinkichi Tawata

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