Fusion Oncoproteins in Childhood Cancers

This feed explores the function of fusion oncoproteins in specific childhood cancers, including those from racial/ethnic minority and underserved groups, and to provide preclinical assessment of potential therapeutics and how fusion oncoproteins influence gene expression to perturb normal cellular programs to block lineage differentiation and development

February 3, 2021

Targeting pan-ETS factors inhibits melanoma progression.

Cancer Research
Lee HuangDeborah Lang
January 30, 2021
Review
Open Access

Drugging the 'undruggable' MYCN oncogenic transcription factor: Overcoming previous obstacles to impact childhood cancers.

Cancer Research
Adam J WolpawYaël P Mossé
January 17, 2021
Review

Supercharging BRD4 with NUT in carcinoma.

Oncogene
Kyle P Eagen, Christopher A French
January 10, 2021
Open Access

YAP/TAZ inhibition reduces metastatic potential of Ewing sarcoma cells

Oncogenesis
Lisa BierbaumerHeinrich Kovar
January 5, 2021
Preprint
Open Access

HDAC6 regulates expression of the oncogenic driver EWSR1-FLI1 through the EWSR1 promoter in Ewing sarcoma

BioRxiv : the Preprint Server for Biology
D. J. Garcia-DominguezL. Hontecillas-Prieto
December 17, 2020

Genetically Engineered Mouse Model in Ewing Sarcoma

Methods in Molecular Biology
Miwa Tanaka, Takuro Nakamura
December 16, 2020
Open Access

annoFuse: an R Package to annotate, prioritize, and interactively explore putative oncogenic RNA fusions

BMC Bioinformatics
Krutika S GaonkarJo Lynne Rokita
December 12, 2020
Case Report
Open Access

Management of primary Ewing sarcoma of the kidney with inferior vena cava (IVC) tumor thrombosis

Urology Case Reports
Mohsen AyatiAmir Behnamfar
December 11, 2020

Immunohistochemical detection of PAX-FOXO1 fusion proteins in alveolar rhabdomyosarcoma using breakpoint specific monoclonal antibodies

Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc
David O AzorsaJaved Khan
December 3, 2020

[Integrative molecular pathology of cancer].

Der Pathologe
Thomas G P Grünewald
November 26, 2020
Open Access

Identification of VRK1 as a New Neuroblastoma Tumor Progression Marker Regulating Cell Proliferation

Cancers
Ana Colmenero-RepisoFrancisco M Vega
October 17, 2020
Open Access

Clinical and molecular characterization of a multi-institutional cohort of pediatric spinal cord low-grade gliomas

Neuro-oncology Advances
Sydney T GrobJean M Mulcahy Levy

Sign up to follow this feed and discover related papers.

Related Feeds

Apoptosis in Cancer

Apoptosis is an important mechanism in cancer. By evading apoptosis, tumors can continue to grow without regulation and metastasize systemically. Many therapies are evaluating the use of pro-apoptotic activation to eliminate cancer growth. Here is the latest research on apoptosis in cancer.

Autophagy & Metabolism

Autophagy preserves the health of cells and tissues by replacing outdated and damaged cellular components with fresh ones. In starvation, it provides an internal source of nutrients for energy generation and, thus, survival. A powerful promoter of metabolic homeostasis at both the cellular and whole-animal level, autophagy prevents degenerative diseases. It does have a downside, however--cancer cells exploit it to survive in nutrient-poor tumors.

Biophysics of Adhesion

Alterations in cell adhesion can disrupt important cellular processes and lead to a variety of diseases, including cancer and arthritis. It is also essential for infectious organisms, such as bacteria or viruses, to cause diseases. Understanding the biophysics of cell adhesion can help understand these diseases. Discover the latest research on the biophysics of adhesion here.

Cancer Biology: Molecular Imaging

Molecular imaging enables noninvasive imaging of key molecules that are crucial to tumor biology. Discover the latest research in molecular imaging in cancer biology in this feed.

Cancer Imaging

Imaging techniques, including CT and MR, have become essential to tumor detection, diagnosis, and monitoring. Here is the latest research on cancer imaging.

Cancer Metabolism

In order for cancer cells to maintain rapid, uncontrolled cell proliferation, they must acquire a source of energy. Cancer cells acquire metabolic energy from their surrounding environment and utilize the host cell nutrients to do so. Here is the latest research on cancer metabolism.

Cell Migration in Cancer and Metastasis

Migration of cancer cells into surrounding tissue and the vasculature is an initial step in tumor metastasis. Discover the latest research on cell migration in cancer and metastasis here.

Cell Signaling by Tyrosine Kinases

Receptor tyrosine kinases (RTKs) are the high-affinity cell surface receptors for many polypeptide growth factors, cytokines, and hormones. RTKs have been shown not only to be key regulators of normal cellular processes but also to have a critical role in the development and progression of many types of cancer. Discover the latest research on cell signaling and RTK here.

Circadian Clock & Cancer

Circadian rhythms are natural, internal processes that regulate the sleep-wake cycle. Chronic disruptions in circadian rhythms have been associated with the development of a variety of diseases including cancer. Here is the latest research on circadian rhythms and cancer.

Circular RNAs in Cancer

Circular RNA (circRNA) are stable non-coding RNAs implicated in gene regulation, cell differentiation, tissue homeostasis, and tumorigenesis. Their role as a potential diagnostic and prognostic biomarker and as a possible therapeutic target is currently under investigation. Here is the latest research on circRNAs in cancer.

© 2021 Meta ULC. All rights reserved
/feed-previews/fusion-oncoproteins-in-childhood/0289a357-5f4c-42b6-9187-1c5488d5103c