Fusion Oncoproteins in Childhood Cancers

This feed explores the function of fusion oncoproteins in specific childhood cancers, including those from racial/ethnic minority and underserved groups, and to provide preclinical assessment of potential therapeutics and how fusion oncoproteins influence gene expression to perturb normal cellular programs to block lineage differentiation and development

August 9, 2019
Open Access

EWS-FLI1 modulated alternative splicing of ARID1A reveals novel oncogenic function through the BAF complex

Nucleic Acids Research
Saravana SelvanathanJeffrey Toretsky
July 23, 2019
Open Access

CIC-DUX4 oncoprotein drives sarcoma metastasis and tumorigenesis via distinct regulatory programs

The Journal of Clinical Investigation
Ross A OkimotoTrever G Bivona
June 18, 2019
Open Access

Catalytic inhibition of KDM1A in Ewing sarcoma is insufficient as a therapeutic strategy

Pediatric Blood & Cancer
Antonio Romo-MoralesJanet M Shipley
July 18, 2019

Integrity of zinc finger motifs in PML protein is necessary for inducing its degradation by antimony

Metallomics : Integrated Biometal Science
Chang YangHua Naranmandura
January 24, 2020
Open Access

Targeting the undruggable: exploiting neomorphic features of fusion oncoproteins in childhood sarcomas for innovative therapies

Cancer Metastasis Reviews
Maximilian M L KnottThomas G P Grünewald
August 14, 2019
Open Access

The SUMO Pathway in Hematomalignancies and Their Response to Therapies

International Journal of Molecular Sciences
Mathias BoulangerGuillaume Bossis
July 1, 2019

Development and Clinical Validation of a Large Fusion Gene Panel for Pediatric Cancers

The Journal of Molecular Diagnostics : JMD
Fengqi ChangMarilyn M Li
November 17, 2019
Open Access

Integrative clinical transcriptome analysis reveals TMPRSS2-ERG dependency of prognostic biomarkers in prostate adenocarcinoma

International Journal of Cancer. Journal International Du Cancer
Julia S GerkeThomas G P Grünewald
March 12, 2020
Open Access

Disruption of oncogenic targeting by ISWI via phosphorylation of a prion-like domain

BioRxiv : the Preprint Server for Biology
Mark ChenDavid G Kirsch
April 24, 2020
Open Access

Epigenetic control of the EWS‑FLI1 promoter in Ewing's sarcoma

Oncology Reports
C MontoyaA Rojas
January 23, 2020

The Evolving Diagnostic and Treatment Landscape of NTRK-Fusion-Driven Pediatric Cancers

Paediatric Drugs
David S Shulman, Steven G DuBois
December 29, 2019
Open Access

The mechanism of MYB transcriptional regulation by MLL-AF9 oncoprotein

Scientific Reports
Lu CaoThomas J Gonda
November 9, 2019

Early Management of CML

Current Hematologic Malignancy Reports
Naranie Shanmuganathan, Timothy P Hughes

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