Fusion Oncoproteins in Childhood Cancers

This feed explores the function of fusion oncoproteins in specific childhood cancers, including those from racial/ethnic minority and underserved groups, and to provide preclinical assessment of potential therapeutics and how fusion oncoproteins influence gene expression to perturb normal cellular programs to block lineage differentiation and development

September 28, 2019

Identification and characterization of a BRAF fusion oncoprotein with retained autoinhibitory domains

Oncogene
Florian WeinbergTilman Brummer
August 12, 2020

v-myb avian myeloblastosis viral oncogene homolog expression is a potential molecular diagnostic marker for B-cell acute lymphoblastic leukemia

Asia-Pacific Journal of Clinical Oncology
Marcela Concepción Caballero-PalaciosSergio Juárez-Méndez
May 18, 2020
Open Access

Oncogenic hijacking of a developmental transcription factor evokes vulnerability toward oxidative stress in Ewing sarcoma

Nature Communications
Aruna MarchettoThomas G P Grünewald
December 8, 2019

All-trans retinoic acid (ATRA)-induced TFEB expression is required for myeloid differentiation in acute promyelocytic leukemia (APL)

European Journal of Haematology
Nina OrfaliNigel P Mongan
February 5, 2020

Monensin, a novel potent MYB inhibitor, suppresses proliferation of acute myeloid leukemia and adenoid cystic carcinoma cells

Cancer Letters
Maria V YusenkoKarl-Heinz Klempnauer
January 24, 2020
Review
Open Access

Targeting the undruggable: exploiting neomorphic features of fusion oncoproteins in childhood sarcomas for innovative therapies

Cancer Metastasis Reviews
Maximilian M L KnottThomas G P Grünewald
August 14, 2019
Review
Open Access

The SUMO Pathway in Hematomalignancies and Their Response to Therapies

International Journal of Molecular Sciences
Mathias BoulangerGuillaume Bossis
August 5, 2020

The nucleosome acidic patch and H2A ubiquitination underlie mSWI/SNF recruitment in synovial sarcoma

Nature Structural & Molecular Biology
Matthew J McBrideCigall Kadoch
August 14, 2020

Allicin, a Potent New Ornithine Decarboxylase Inhibitor in Neuroblastoma Cells

Journal of Natural Products
Chad R SchultzAndré S Bachmann
July 18, 2020

Biotransformation of arsenic trioxide by AS3MT favors eradication of acute promyelocytic leukemia: revealing the hidden facts

Drug Metabolism Reviews
Yasen MaimaitiyimingHua Naranmandura
July 14, 2020

Global PROTAC Toolbox for Degrading BCR-ABL Overcomes Drug-Resistant Mutants and Adverse Effects

Journal of Medicinal Chemistry
Yiqing YangYu Rao
December 28, 2019
Open Access

Hippo pathway effectors YAP1/TAZ induce an EWS-FLI1-opposing gene signature and associate with disease progression in Ewing sarcoma

The Journal of Pathology
Pablo Rodríguez-NúñezJuan Díaz-Martín
November 17, 2019
Open Access

Integrative clinical transcriptome analysis reveals TMPRSS2-ERG dependency of prognostic biomarkers in prostate adenocarcinoma

International Journal of Cancer. Journal International Du Cancer
Julia S GerkeThomas G P Grünewald
March 12, 2020
Preprint
Open Access

Disruption of oncogenic targeting by ISWI via phosphorylation of a prion-like domain

BioRxiv : the Preprint Server for Biology
Mark ChenDavid G Kirsch
August 6, 2020
Review
Open Access

The Role of Tyrosine Kinases as a Critical Prognostic Parameter and Its Targeted Therapies in Ewing Sarcoma

Frontiers in Cell and Developmental Biology
Wook Jin
April 24, 2020
Open Access

Epigenetic control of the EWS‑FLI1 promoter in Ewing's sarcoma

Oncology Reports
C MontoyaA Rojas
January 23, 2020
Review

The Evolving Diagnostic and Treatment Landscape of NTRK-Fusion-Driven Pediatric Cancers

Paediatric Drugs
David S Shulman, Steven G DuBois

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