Fusion Oncoproteins in Childhood Cancers

This feed explores the function of fusion oncoproteins in specific childhood cancers, including those from racial/ethnic minority and underserved groups, and to provide preclinical assessment of potential therapeutics and how fusion oncoproteins influence gene expression to perturb normal cellular programs to block lineage differentiation and development

September 28, 2019

Identification and characterization of a BRAF fusion oncoprotein with retained autoinhibitory domains

Florian WeinbergTilman Brummer
August 12, 2020

v-myb avian myeloblastosis viral oncogene homolog expression is a potential molecular diagnostic marker for B-cell acute lymphoblastic leukemia

Asia-Pacific Journal of Clinical Oncology
Marcela Concepción Caballero-PalaciosSergio Juárez-Méndez
May 18, 2020
Open Access

Oncogenic hijacking of a developmental transcription factor evokes vulnerability toward oxidative stress in Ewing sarcoma

Nature Communications
Aruna MarchettoThomas G P Grünewald
December 8, 2019

All-trans retinoic acid (ATRA)-induced TFEB expression is required for myeloid differentiation in acute promyelocytic leukemia (APL)

European Journal of Haematology
Nina OrfaliNigel P Mongan
February 5, 2020

Monensin, a novel potent MYB inhibitor, suppresses proliferation of acute myeloid leukemia and adenoid cystic carcinoma cells

Cancer Letters
Maria V YusenkoKarl-Heinz Klempnauer
January 24, 2020
Open Access

Targeting the undruggable: exploiting neomorphic features of fusion oncoproteins in childhood sarcomas for innovative therapies

Cancer Metastasis Reviews
Maximilian M L KnottThomas G P Grünewald
August 14, 2019
Open Access

The SUMO Pathway in Hematomalignancies and Their Response to Therapies

International Journal of Molecular Sciences
Mathias BoulangerGuillaume Bossis
August 5, 2020

The nucleosome acidic patch and H2A ubiquitination underlie mSWI/SNF recruitment in synovial sarcoma

Nature Structural & Molecular Biology
Matthew J McBrideCigall Kadoch
August 14, 2020

Allicin, a Potent New Ornithine Decarboxylase Inhibitor in Neuroblastoma Cells

Journal of Natural Products
Chad R SchultzAndré S Bachmann
July 18, 2020

Biotransformation of arsenic trioxide by AS3MT favors eradication of acute promyelocytic leukemia: revealing the hidden facts

Drug Metabolism Reviews
Yasen MaimaitiyimingHua Naranmandura
July 14, 2020

Global PROTAC Toolbox for Degrading BCR-ABL Overcomes Drug-Resistant Mutants and Adverse Effects

Journal of Medicinal Chemistry
Yiqing YangYu Rao
December 28, 2019
Open Access

Hippo pathway effectors YAP1/TAZ induce an EWS-FLI1-opposing gene signature and associate with disease progression in Ewing sarcoma

The Journal of Pathology
Pablo Rodríguez-NúñezJuan Díaz-Martín
November 17, 2019
Open Access

Integrative clinical transcriptome analysis reveals TMPRSS2-ERG dependency of prognostic biomarkers in prostate adenocarcinoma

International Journal of Cancer. Journal International Du Cancer
Julia S GerkeThomas G P Grünewald
March 12, 2020
Open Access

Disruption of oncogenic targeting by ISWI via phosphorylation of a prion-like domain

BioRxiv : the Preprint Server for Biology
Mark ChenDavid G Kirsch
August 6, 2020
Open Access

The Role of Tyrosine Kinases as a Critical Prognostic Parameter and Its Targeted Therapies in Ewing Sarcoma

Frontiers in Cell and Developmental Biology
Wook Jin
April 24, 2020
Open Access

Epigenetic control of the EWS‑FLI1 promoter in Ewing's sarcoma

Oncology Reports
C MontoyaA Rojas
January 23, 2020

The Evolving Diagnostic and Treatment Landscape of NTRK-Fusion-Driven Pediatric Cancers

Paediatric Drugs
David S Shulman, Steven G DuBois

Sign up to follow this feed and discover related papers.

Related Feeds

Apoptosis in Cancer

Apoptosis is an important mechanism in cancer. By evading apoptosis, tumors can continue to grow without regulation and metastasize systemically. Many therapies are evaluating the use of pro-apoptotic activation to eliminate cancer growth. Here is the latest research on apoptosis in cancer.

Autophagy & Metabolism

Autophagy preserves the health of cells and tissues by replacing outdated and damaged cellular components with fresh ones. In starvation, it provides an internal source of nutrients for energy generation and, thus, survival. A powerful promoter of metabolic homeostasis at both the cellular and whole-animal level, autophagy prevents degenerative diseases. It does have a downside, however--cancer cells exploit it to survive in nutrient-poor tumors.

Autophagy: Cancer & Parkinson

Autophagy leads to degradation of damaged proteins and organelles by the lysosome. Impaired autophagy has been implicated in several diseases. Here is the role of autophagy in cancer and Parkinson’s.

Biophysics of Adhesion

Alterations in cell adhesion can disrupt important cellular processes and lead to a variety of diseases, including cancer and arthritis. It is also essential for infectious organisms, such as bacteria or viruses, to cause diseases. Understanding the biophysics of cell adhesion can help understand these diseases. Discover the latest research on the biophysics of adhesion here.

Cancer Biology: Molecular Imaging

Molecular imaging enables noninvasive imaging of key molecules that are crucial to tumor biology. Discover the latest research in molecular imaging in cancer biology in this feed.

Cancer Imaging

Imaging techniques, including CT and MR, have become essential to tumor detection, diagnosis, and monitoring. Here is the latest research on cancer imaging.

Cancer Metabolism

In order for cancer cells to maintain rapid, uncontrolled cell proliferation, they must acquire a source of energy. Cancer cells acquire metabolic energy from their surrounding environment and utilize the host cell nutrients to do so. Here is the latest research on cancer metabolism.

Cell Migration in Cancer and Metastasis

Migration of cancer cells into surrounding tissue and the vasculature is an initial step in tumor metastasis. Discover the latest research on cell migration in cancer and metastasis here.

Cell Signaling by Tyrosine Kinases

Receptor tyrosine kinases (RTKs) are the high-affinity cell surface receptors for many polypeptide growth factors, cytokines, and hormones. RTKs have been shown not only to be key regulators of normal cellular processes but also to have a critical role in the development and progression of many types of cancer. Discover the latest research on cell signaling and RTK here.

Circadian Clock & Cancer

Circadian rhythms are natural, internal processes that regulate the sleep-wake cycle. Chronic disruptions in circadian rhythms have been associated with the development of a variety of diseases including cancer. Here is the latest research on circadian rhythms and cancer.

© 2020 Meta ULC. All rights reserved