G-Protein-Coupled Receptors (Preprints)

G-protein-coupled receptors (GPCRs), the largest family of integral membrane proteins, participate in the regulation of many physiological functions and are the targets of approximately 30% of currently marketed drugs. Here are the latest preprints on GPCRs.

July 15, 2020
Preprint
Open Access

Early life stress dysregulates kappa opioid receptor signaling within the lateral habenula

BioRxiv : the Preprint Server for Biology
S. C. SimmonsFereshteh S Nugent
July 24, 2020
Preprint
Open Access

In Silico Driven Prediction of MAPK14 Off-Targets Reveals Unrelated Proteins with High Accuracy

BioRxiv : the Preprint Server for Biology
F. KaiserV. Joachim Haupt
July 29, 2020
Preprint

Time-resolved proteomic profiling of the ciliary Hedgehog response reveals that GPR161 and PKA undergo regulated co-exit from cilia

BioRxiv : the Preprint Server for Biology
E. A. MayDavid U Mick
July 15, 2020
Preprint
Open Access

A structural model of a Ras-Raf signalosome

BioRxiv : the Preprint Server for Biology
V. P. MysoreD. Shaw
July 27, 2020
Preprint
Open Access

Widespread non-apoptotic activation of Drosophila Caspase-2/9 limits JNK signaling, macrophage proliferation and growth of wound-like tumors

BioRxiv : the Preprint Server for Biology
D. C. XuL. A. B. Lopez
July 23, 2020
Preprint
Open Access

Activation microswitches in GPCRs function as rheostats in cell membrane

BioRxiv : the Preprint Server for Biology
N. MaNagarajan Vaidehi
July 24, 2020
Preprint
Open Access

Expression, subcellular localization, and phosphorylation of MK5 in adult cardiac ventricular fibroblasts

BioRxiv : the Preprint Server for Biology
P. SahadevanBruce G Allen
July 17, 2020
Preprint
Open Access

Translation regulation of Japanese encephalitis virus revealed by ribosome profiling

BioRxiv : the Preprint Server for Biology
V. A. RizviRahul Roy
July 27, 2020
Preprint
Open Access

Evolution And Genetic Diversity Of SARSCoV-2 In Africa Using Whole Genome Sequences

BioRxiv : the Preprint Server for Biology
Babatunde Olanrewaju MotayoA. O. Faneye
July 10, 2020
Preprint
Open Access

Functional and structural characterization of allosteric activation of Phospholipase Cϵ by Rap1A

BioRxiv : the Preprint Server for Biology
July 29, 2020
Preprint

Crystal structure reveals the full Ras:Raf interface and advances mechanistic understanding of Raf activation

BioRxiv : the Preprint Server for Biology
T. Cookis, Carla Mattos
July 22, 2020
Preprint
Open Access

Distinct specificity of two pheromone G-protein coupled receptors, Map3 and Mam2, in fission yeast species.

BioRxiv : the Preprint Server for Biology
Taisuke SeikeC. Furusawa
July 17, 2020
Preprint
Open Access

Echis carinatus snake venom metalloprotease-induced toxicities in mice: therapeutic intervention by a repurposed drug, tetraethylthiuram disulfide (disulfiram)

BioRxiv : the Preprint Server for Biology
G. V. RudreshaBannikuppe Vishwanath
July 12, 2020
Preprint
Open Access

Endophilin Recruitment via GPCR Interactions Enables Membrane Curvature Generation in the Absence of Anionic Lipids

BioRxiv : the Preprint Server for Biology
July 30, 2020
Preprint

The mode of expression divergence in Drosophila fat body is infection-specific

BioRxiv : the Preprint Server for Biology
B. A. Ramirez-CoronaZeba Wunderlich
July 21, 2020
Preprint
Open Access

Can the creation of new freshwater habitat demographically offset losses of Pacific salmon from chronic anthropogenic mortality?

BioRxiv : the Preprint Server for Biology
Pascale GibeauM. J. Bradford
July 17, 2020
Preprint
Open Access

Free-fatty acid receptor 4 inhibitory signaling in delta cells regulates islet hormone secretion in mice

BioRxiv : the Preprint Server for Biology
M. L. CrozeVincent Poitout
July 28, 2020
Preprint

Zn2+ influx activates ERK and Akt signaling pathways through a common mechanism

BioRxiv : the Preprint Server for Biology
K. J. AnsonAmy Elizabeth Palmer
July 10, 2020
Preprint
Open Access

Effects of pharmacological calcimimetics on colorectal cancer cells over-expressing the human calcium-sensing receptor

BioRxiv : the Preprint Server for Biology

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