Feed Preview

Fast Growing

Genetic Screens in iPSC-Derived Brain Cells

Genetic Screens in iPSC-Derived Brain Cells diagram by Stephen J. Pettitt et al
Stephen J. Pettitt et al

Genetic screening is a critical tool that can be employed to define and understand gene function and interaction. This feed focuses on genetic screens conducted using induced pluripotent stem cell (iPSC)-derived brain cells.

Top 20 most recent papers
Nature Genetics

Genome-scale screens identify JNK-JUN signaling as a barrier for pluripotency exit and endoderm differentiation

Nature GeneticsMay 22, 2019
Qing Hua LiDanwei Huangfu
50
40
Genome Biology

A genomic atlas of systemic interindividual epigenetic variation in humans

Genome BiologyJune 3, 2019
Chathura J GunasekaraRobert A Waterland
131
7
1
75
Cell Stem Cell

Human iPSC-Derived Blood-Brain Barrier Chips Enable Disease Modeling and Personalized Medicine Applications

Cell Stem CellJune 6, 2019
Gad David VatineClive Niels Svendsen
59
13
2
100
bioRxiv

Cell-Surface Proteomic Profiling in the Fly Brain Uncovers New Wiring Regulators

bioRxivOctober 25, 2019
Jiefu LiLiqun Luo
59
Nature Communications

Nuclei multiplexing with barcoded antibodies for single-nucleus genomics

Nature CommunicationsJuly 2, 2019
Jellert T. GaublommeAviv D Regev
25
2
97
bioRxiv

In vivo Perturb-Seq reveals neuronal and glial abnormalities associated with Autism risk genes

bioRxivOctober 7, 2019
Xin JinPaola Arlotta
110
Scientific Reports

Targeted genomic CRISPR-Cas9 screen identifies MAP4K4 as essential for glioblastoma invasion

Scientific ReportsSeptember 30, 2019
Laura M ProloGerald A Grant
3
bioRxiv

Dendrites with specialized glial attachments develop by retrograde extension using SAX-7 and GRDN-1

bioRxivOctober 11, 2019
Elizabeth R. CebulMaxwell G. Heiman
23
The EMBO Journal

SLC1A3 contributes to L-asparaginase resistance in solid tumors

The EMBO JournalSeptember 17, 2019
Jian-Hui SunReuven Agami
6
bioRxiv

Prospective Isolation of Chondroprogenitors from Human iPSCs Based on Cell Surface Markers Identified using a CRISPR-Cas9-Generated Reporter

bioRxivJune 19, 2019
Amanda DicksFarshid Guilak
20
5
Neuro-oncology

A large-scale drug screen identifies selective inhibitors of class I HDACs as a potential therapeutic option for SHH medulloblastoma

Neuro-oncologyMay 16, 2019
Ekaterina PakRosalind A. Segal
1
2
Scientific Reports

Proof-of-Concept Study of Drug Brain Permeability Between in Vivo Human Brain and an in Vitro iPSCs-Human Blood-Brain Barrier Model

Scientific ReportsNovember 5, 2019
Gwenaëlle Le RouxAloïse M Mabondzo
G3 : Genes - Genomes - Genetics

Expression-Based Cell Lineage Analysis in Drosophila Through a Course-Based Research Experience for Early Undergraduates

G3 : Genes - Genomes - GeneticsNovember 5, 2019
John M OlsonUtpal Banerjee
13
Science

Genetic behavioral screen identifies an orphan anti-opioid system

ScienceAugust 17, 2019
Dandan WangKirill A Martemyanov
143
12
5
66
1
Proceedings of the National Academy of Sciences of the United States of America

Genome-wide CRISPR screen for Zika virus resistance in human neural cells

Proceedings of the National Academy of Sciences of the United States of AmericaApril 26, 2019
Yun LiRudolf Jaenisch
29
1
39
bioRxiv

Global kinome silencing combined with 3D invasion screening of the tumor microenvironment identifies fibroblast-expressed PIK3Cδ involvement in triple-negative breast cancer progression

bioRxivNovember 2, 2019
Teresa GaglianoGeorgios Giamas
7
bioRxiv

Lipid droplet accumulating microglia represent a dysfunctional and pro-inflammatory state in the aging brain

bioRxivAugust 6, 2019
Julia MarschallingerTony Wyss-Coray
120
55
Nature Biomedical Engineering

High-throughput genome-wide phenotypic screening via immunomagnetic cell sorting

Nature Biomedical EngineeringSeptember 23, 2019
Barbara MairShana Olwyn Kelley
46
7
3
Molecules and Cells

ApoE4-Induced Cholesterol Dysregulation and Its Brain Cell Type-Specific Implications in the Pathogenesis of Alzheimer's Disease

Molecules and CellsNovember 12, 2019
Woo-Jin JeongJin-Soo Seo
1
bioRxiv

Rab11b-mediated integrin recycling promotes brain metastatic adaptation and outgrowth

bioRxivJune 11, 2019
Erin N HoweSi-yuan Zhang
16

See more papers from this feed

Related Feeds

ALS

Amyotrophic Lateral Sclerosis (ALS), also known as motor neuron disease, is associated with the death of neurons that control voluntary muscles. Discover the latest research on ALS here.

ALS & FTD: TDP-43

ALS shares with a considerable proportion of FTD cases the same neuropathological substrate, namely, inclusions of abnormally phosphorylated protein tdp-43 (ptdp-43). Here are the latest discoveries pertaining to ptdp-43 and these diseases.

ALS - Pathogenic Mechanisms

Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disorder characterized by muscle weakness. Here is the latest research investigating pathogenic mechanisms that underlie this genetically heterogeneous disorder.

ALS - Phenotypes

Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disorder characterized by muscle weakness. Here is the latest research investigating phenotypes associated with this genetically heterogeneous disorder.

ALS: Genetics

Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disorder characterized by muscle weakness. ALS is a genetically heterogeneous disorder with several causative genes. Here are the latest discoveries pertaining to the genetics of this disease.

ALS: Prions

Prions are misfolded proteins which characterize several fatal neurodegenerative diseases. Prion-like mechanisms are associated with the pathogenesis of Amyotrophic Lateral Sclerosis (ALS). Here are the latest discoveries pertaining to this disease.

ALS: Stress Granules

Amyotrophic Lateral Sclerosis (ALS) is a neurodegenerative disease characterized by cytoplasmic protein aggregates within motor neurons. TDP-43 is an ALS-linked protein that is known to regulate splicing and storage of specific mRNAs into stress granules, which have been implicated in formation of ALS protein aggregates. Here is the latest research.

ALS: Therapies

Amyotrophic Lateral Sclerosis (ALS), also known as motor neuron disease, is associated with the death of neurons that control voluntary muscles. Discover the latest research on ALS therapies here.

ALS: Transposon de-silencing

Transposon silencing is a form of transcriptional gene silencing. These gene silencing mechanisms are impaired in Amyotrophic lateral sclerosis (ALS). Here are the latest discoveries pertaining to transposon silencing and this disease.

Acute Myeloid Leukaemia & RNA

Acute myeloid leukaemia (AML) is a common hematological type of cancer. As the population ages, there has been a rise in the frequency of AML. RNA expression has been used to see if there are different genetic profiles that exist within AML and whether these may underpin the variations in survival rates. Here is the latest research on AML and RNA.

© 2019 Meta ULC. All rights reserved
/feed-previews/genetic-screens-in-ipsc-derived-brain/6f946d3b-d249-4260-ac32-ae2568df392c