Genetic Screens in iPSC-Derived Brain Cells

Genetic screening is a critical tool that can be employed to define and understand gene function and interaction. This feed focuses on genetic screens conducted using induced pluripotent stem cell (iPSC)-derived brain cells.

January 19, 2019

Making NSC and Neurons from Patient-Derived Tissue Samples

Methods in Molecular Biology
Odity MukherjeeMahendra Rao
March 31, 2019

LRRK2 modifies α-syn pathology and spread in mouse models and human neurons

Acta Neuropathologica
Gregor BieriAaron D. Gitler
July 12, 2018
Open Access

An in vitro paradigm to assess potential anti-Aβ antibodies for Alzheimer's disease

Nature Communications
Ming JinDominic M Walsh
July 24, 2018

Generation of a human induced pluripotent stem cell-based model for tauopathies combining three microtubule-associated protein TAU mutations which displays several phenotypes linked to neurodegeneration

Alzheimer's & Dementia : the Journal of the Alzheimer's Association
Juan Antonio García-LeónCatherine M Verfaillie
February 22, 2020
Review
Open Access

Human-Induced Pluripotent Stem Cells and Herbal Small-Molecule Drugs for Treatment of Alzheimer's Disease

International Journal of Molecular Sciences
Wei WuliHorng-Jyh Harn
March 25, 2019
Open Access

Genome-Scale CRISPRa Screen Identifies Novel Factors for Cellular Reprogramming

Stem Cell Reports
Jian YangEmmanouil Metzakopian
October 22, 2019

Stem cell derived oligodendrocytes to study myelin diseases

Glia
Konstantina ChanoumidouTanja Kuhlmann
January 29, 2020
Open Access

Rescuing compounds for Lesch-Nyhan disease identified using stem cell-based phenotypic screening

JCI Insight
Valentin RuillierAlexandra Benchoua
April 6, 2019
Comment / Editorial
Open Access

Stars in the Night Sky: iPSC-Cardiomyocytes Return the Patient Context to Drug Screening

Cell Stem Cell
Anna Hnatiuk, Mark Mercola
September 21, 2018
Review

In vitro Models for Seizure-Liability Testing Using Induced Pluripotent Stem Cells

Frontiers in Neuroscience
Alastair I GraingerEric J Hill
December 20, 2018

Pathological Changes in Alzheimer's Disease Analyzed Using Induced Pluripotent Stem Cell-Derived Human Microglia-Like Cells

Journal of Alzheimer's Disease : JAD
Mei XuYongxiang Zhang
May 30, 2020

NitroSynapsin ameliorates hypersynchronous neural network activity in Alzheimer hiPSC models

Molecular Psychiatry
Swagata GhatakStuart A Lipton
February 18, 2020

ASCL1- and DLX2-induced GABAergic neurons from hiPSC-derived NPCs

Journal of Neuroscience Methods
Natalie BarrettoKristen J Brennand

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