Genetic Screens in iPSC-derived Brain Cells

Genetic screening is a critical tool that can be employed to define and understand gene function and interaction. This feed focuses on genetic screens conducted using induced pluripotent stem cell (iPSC)-derived brain cells. It also follows CRISPR-Cas9 approaches to generating genetic mutants as a means of understanding the effect of genetics on phenotype.

January 4, 2022
Open Access

Mechanisms of Arrhythmogenicity of Hypertrophic Cardiomyopathy-Associated Troponin T (TNNT2) Variant I79N.

Frontiers in Cell and Developmental Biology
Sanam ShafaattalabGlen F Tibbits
December 31, 2021

Defining the role of PLD3 in Alzheimer's disease pathology.

Alzheimer's & Dementia : the Journal of the Alzheimer's Association
Matthew J RoseneCeleste M Karch
November 28, 2021
Review
Open Access

Human iPSC-Derived Neurons as A Platform for Deciphering the Mechanisms behind Brain Aging.

Biomedicines
Chuan-Chuan ChaoYu-Hui Wong
November 24, 2021
Preprint
Open Access

Young transposable elements rewired gene regulatory networks in human and chimpanzee hippocampal intermediate progenitors

BioRxiv : the Preprint Server for Biology
S. PatooriMarco Trizzino
November 23, 2021
Review

3D hydrogel models of the neurovascular unit to investigate blood-brain barrier dysfunction.

Neuronal Signaling
Geoffrey PotjewydNigel M Hooper
October 30, 2021
Review
Open Access

Non-immunogenic Induced Pluripotent Stem Cells, a Promising Way Forward for Allogenic Transplantations for Neurological Disorders.

Frontiers in Genome Editing
Henriette Reventlow FrederiksenKristine K Freude
October 11, 2021

Midbrain organoids with an SNCA gene triplication model key features of synucleinopathy.

Brain Communications
Nguyen-Vi MohamedThomas M Durcan
July 30, 2021

CRISPR/Cas9 Genome Engineering in Human Pluripotent Stem Cells for Modeling of Neurological Disorders.

Methods in Molecular Biology
Isaac Canals, Henrik Ahlenius
July 24, 2021
Review
Open Access

Blood-Brain Barrier and Neurodegenerative Diseases-Modeling with iPSC-Derived Brain Cells.

International Journal of Molecular Sciences
Ying-Chieh WuŠárka Lehtonen
July 13, 2021
Review
Open Access

Cholesterol and Alzheimer's Disease; From Risk Genes to Pathological Effects.

Frontiers in Aging Neuroscience
Femke M Feringa, Rik van der Kant
July 3, 2021
Open Access

PINK1 gene mutation by pair truncated sgRNA/Cas9-D10A in cynomolgus monkeys.

Zoological Research
Zhen-Zhen ChenYu-Yu Niu
June 29, 2021
Review
Open Access

Human neural organoids: Models for developmental neurobiology and disease.

Developmental Biology
Brian GuyRobert J Johnston
June 21, 2021
Open Access

Using the dCas9-KRAB system to repress gene expression in hiPSC-derived NGN2 neurons.

STAR Protocols
Aiqun LiKristen J Brennand
June 21, 2021
Open Access

Generation and validation of APOE knockout human iPSC-derived cerebral organoids.

STAR Protocols
Yuka A MartensJing Zhao
May 5, 2021
Open Access

DSCAM/PAK1 pathway suppression reverses neurogenesis deficits in iPSC-derived cerebral organoids from patients with Down syndrome.

The Journal of Clinical Investigation
Xiao-Yan TangYan Liu
May 3, 2021
Preprint
Open Access

Human iPSC-derived brain endothelial microvessels in a multi-well format enable permeability screens of anti-inflammatory drugs

BioRxiv : the Preprint Server for Biology
S. FenglerE. Fava
April 28, 2021
Open Access

Abnormalities of mitochondrial dynamics and bioenergetics in neuronal cells from CDKL5 deficiency disorder.

Neurobiology of Disease
Nicole J Van BergenJohn Christodoulou

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