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Genetic Screens in iPSC-Derived Brain Cells

Genetic Screens in iPSC-Derived Brain Cells diagram by Zhang, Wikimedia
Zhang, Wikimedia

Genetic screening is a critical tool that can be employed to define and understand gene function and interaction. This feed focuses on genetic screens conducted using induced pluripotent stem cell (iPSC)-derived brain cells.

Top 20 most recent papers
Science

Genetic behavioral screen identifies an orphan anti-opioid system

ScienceAugust 17, 2019
Dandan WangKirill A Martemyanov
141
12
5
75
1
bioRxiv

Cell-Surface Proteomic Profiling in the Fly Brain Uncovers New Wiring Regulators

bioRxivOctober 25, 2019
Jiefu LiLiqun Luo
59
24
bioRxiv

Massively parallel disruption of enhancers active during human corticogenesis

bioRxivDecember 2, 2019
Evan GellerJames P Noonan
33
Science Translational Medicine

GDNF rescues the fate of neural progenitor grafts by attenuating Notch signals in the injured spinal cord in rodents

Science Translational MedicineJanuary 10, 2020
Mohamad KhazaeiMichael G Fehlings
20
2
bioRxiv

A Genetic Screen Links the Disease-Associated Nab2 RNA-Binding Protein to the Planar Cell Polarity Pathway in Drosophila melanogaster

bioRxivDecember 23, 2019
Wei-Hsuan LeeKen Moberg
8
bioRxiv

Minimized double guide RNA libraries enable scale-limited CRISPR/Cas9 screens

bioRxivNovember 29, 2019
Elin Madli PeetsLeopold Parts
65
Cell

Cell-Surface Proteomic Profiling in the Fly Brain Uncovers Wiring Regulators

CellJanuary 21, 2020
Jiefu LiLiqun Luo
159
4
2
Neuron

CRISPR-Cas9 Screens Identify the RNA Helicase DDX3X as a Repressor of C9ORF72 (GGGGCC)n Repeat-Associated Non-AUG Translation

NeuronOctober 8, 2019
Weiwei ChengShuying Sun
56
1
59
bioRxiv

Chr21 protein-protein interactions: enrichment in products involved in intellectual disabilities, autism and Late Onset Alzheimer Disease

bioRxivDecember 12, 2019
Julia ViardAude-Marie Lepagnol-Bestel
10
bioRxiv

Global kinome silencing combined with 3D invasion screening of the tumor microenvironment identifies fibroblast-expressed PIK3Cδ involvement in triple-negative breast cancer progression

bioRxivNovember 2, 2019
Teresa GaglianoGeorgios Giamas
7
1
bioRxiv

In vivo Perturb-Seq reveals neuronal and glial abnormalities associated with Autism risk genes

bioRxivOctober 7, 2019
Xin JinPaola Arlotta
129
52
bioRxiv

Lipid droplet accumulating microglia represent a dysfunctional and pro-inflammatory state in the aging brain

bioRxivAugust 6, 2019
Julia MarschallingerTony Wyss-Coray
120
63
bioRxiv

Adaptive Introgression Promotes Fast Adaptation In Oaks Marginal Populations

bioRxivAugust 12, 2019
Pablo G GoicoecheaAntoine Kremer
7
4
Nature Neuroscience

Lipid-droplet-accumulating microglia represent a dysfunctional and proinflammatory state in the aging brain

Nature NeuroscienceJanuary 22, 2020
Julia MarschallingerTony Wyss-Coray
241
1
Cell Reports

A High-Content Screen Identifies TPP1 and Aurora B as Regulators of Axonal Mitochondrial Transport

Cell ReportsSeptember 19, 2019
Evgeny ShlevkovThomas L Schwarz
21
27
bioRxiv

Cortical Overgrowth in a Preclinical Forebrain Organoid Model of CNTNAP2-Associated Autism Spectrum Disorder

bioRxivAugust 19, 2019
Job O de JongSander Markx
11
3
Regenerative Therapy

Ropinirole hydrochloride remedy for amyotrophic lateral sclerosis - Protocol for a randomized, double-blind, placebo-controlled, single-center, and open-label continuation phase I/IIa clinical trial (ROPALS trial)

Regenerative TherapyAugust 7, 2019
Satoru MorimotoJin Nakahara
2
15
EMBO Reports

A genome-wide screen identifies IRF2 as a key regulator of caspase-4 in human cells

EMBO ReportsJuly 30, 2019
Sacha BenaoudiaThomas Henry
4
20
Neuron

CRISPR Interference-Based Platform for Multimodal Genetic Screens in Human iPSC-Derived Neurons

NeuronAugust 20, 2019
Ruilin TianMartin Kampmann
108
6
155
Stem Cell Research

Generation of the induced human pluripotent stem cell lines CSSi009-A from a patient with a GNB5 pathogenic variant, and CSSi010-A from a CRISPR/Cas9 engineered GNB5 knock-out human cell line

Stem Cell ResearchSeptember 4, 2019
Natascia MalerbaGiuseppe Merla
1
4

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