Killer-cell immunoglobulin-like receptors (KIRs) are expressed on NK cells and a subset of T cells and mediate inhibition or activation of cytotoxic activity. KIRs are highly polymorphic and the ability to sequence and phenotype these variations may lead to a better understanding of various infectious and autoimmune pathologies. Find the latest research on KIRs here.
Antibody repertoire diversity and its role during natural infection is a prerequisite for molecular and structural elucidation of functionally protective immunity. Discover the latest insights into antibody diversity here.
HLA genetic variation has been found to confer risk for a wide variety of diseases. Identifying these associations and understanding their molecular mechanisms is ongoing and holds promise for the development of therapeutics. Find the latest research on HLA genetic variation here.
The immunogenetics of HIV dieases is examined in the context of GWAS, T cell responses, KIRs and more
Multiple sclerosis (MS) was one of the first conditions shown to be associated with HLA class II factors. Find the latest research on MS here, including HLA studies providing insights on the genetics of the susceptibility to MS.
Rheumatoid arthritis is an autoimmune disease for which over 100 genetic risk loci have been identified. Genes involved in T cell receptor signalling, the JAK-STAT signalling pathway, and NF-kB signalling are enriched. Find the latest research on the immunogenetics of rheumatoid arthritis here.
SLE is an autoimmune disease whose cause remains unclear and for which only symptomatic treatments currently exist. Linking the genetic and epigenetic assocations to molecular pathways and cellular phenotype is required to understand this disease and advance therapeutics. Find the latest research on the immunnogenetics of SLE here.
This feed focuses on the role of mutations in immune genes leading to Type 1 Diabetes, an autoimmune disease.