Genetics of Killer-cell Immunoglobulin-like Receptors

Killer-cell immunoglobulin-like receptors (KIRs) are expressed on NK cells and a subset of T cells and mediate inhibition or activation of cytotoxic activity. KIRs are highly polymorphic and the ability to sequence and phenotype these variations may lead to a better understanding of various infectious and autoimmune pathologies. Find the latest research on KIRs here.

April 18, 2020
Open Access

KIR Variation in Iranians Combines High Haplotype and Allotype Diversity With an Abundance of Functional Inhibitory Receptors

Frontiers in Immunology
Claudia AlicataPaul J Norman
April 10, 2020

Killer cell immunoglobulin-like receptor gene cluster predisposes to susceptibility to B-cell acute lymphoblastic leukemia in Chinese children

International Journal of Clinical and Experimental Pathology
Mingyan JiangQiang Li
April 7, 2020
Open Access

Inhibitory KIR ligands are associated with higher P. falciparum parasite prevalence

MedRxiv : the Preprint Server for Health Sciences
J. C. DigitaleMargaret E Feeney
May 8, 2020

Significance of KIR like natural killer cell receptors in autoimmune disorders

Clinical Immunology : the Official Journal of the Clinical Immunology Society
Suraksha Agrawal, Swayam Prakash
April 10, 2020
Open Access

Diversity of peripheral blood human NK cells identified by single-cell RNA sequencing

Blood Advances
Samantha L SmithDaniel M Davis
May 26, 2020
Open Access

Maternal killer-cell immunoglobulin-like receptors and paternal human leukocyte antigen ligands in recurrent pregnancy loss cases in Turkey

Clinical and Experimental Reproductive Medicine
Mehmet Onur ElbaşıEmel Ekşioğlu-Demiralp
April 25, 2020
Open Access

In silico tools for accurate HLA and KIR inference from clinical sequencing data empower immunogenetics on individual-patient and population scales

BioRxiv : the Preprint Server for Biology
J. ChenChristian Hammer
April 9, 2020
Open Access

Combined Effects of HLA-B*57/5801 Elite Suppressor CD8+ T Cells and NK Cells on HIV-1 Replication

Frontiers in Cellular and Infection Microbiology
Megan E MayJoel N Blankson
June 23, 2020
Open Access

HLAs, TCRs, and KIRs, a Triumvirate of Human Cell-Mediated Immunity

Annual Review of Biochemistry
Zakia Djaoud, Peter Parham
June 21, 2020

Natural killer cells and reproductive success

American Journal of Reproductive Immunology : AJRI
Gavin Sacks, Emma Finkelstein
April 15, 2020
Open Access

A DNA vaccine strategy to activate natural killer cells for therapeutic targeting of XPO1-positive tumors

BioRxiv : the Preprint Server for Biology
P. RettmanSalim I Khakoo
June 17, 2020
Open Access

Variations in killer-cell immunoglobulin-like receptor and human leukocyte antigen genes and immunity to malaria

Cellular & Molecular Immunology
Stephen TukwasibweFrancesco Colucci
June 12, 2020

The effect of KIR and HLA polymorphisms on dengue infection and disease severity in northeastern Thais

Medical Microbiology and Immunology
Suwit ChaisriChanvit Leelayuwat
April 26, 2020

TGF-β and IL-15 Synergize through MAPK Pathways to Drive the Conversion of Human NK Cells to an Innate Lymphoid Cell 1-like Phenotype

The Journal of Immunology : Official Journal of the American Association of Immunologists
Lindsey G HawkeMark L Ormiston
April 26, 2020

Protective and causative killer Ig-like receptor (KIR) and metalloproteinase genetic patterns associated with Herpes simplex virus 1 (HSV-1) encephalitis occurrence

Journal of Neuroimmunology
Antonino TuttolomondoKIRIIND (KIR Infectious and Inflammatory Diseases) Collaborative Group

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