Genetics of Killer-cell Immunoglobulin-like Receptors

Killer-cell immunoglobulin-like receptors (KIRs) are expressed on NK cells and a subset of T cells and mediate inhibition or activation of cytotoxic activity. KIRs are highly polymorphic and the ability to sequence and phenotype these variations may lead to a better understanding of various infectious and autoimmune pathologies. Find the latest research on KIRs here.

October 24, 2021

Epithelial cells remove precancerous cells by cell competition via MHC class I-LILRB3 interaction.

Nature Immunology
Shiyu AyukawaTakeshi Maruyama
October 15, 2021
Open Access

γδ T cells are effectors of immune checkpoint blockade in mismatch repair-deficient colon cancers with antigen presentation defects

BioRxiv : the Preprint Server for Biology
Natasja L de VriesE. E. Voest
October 11, 2021

Remarkably low KIR and HLA diversity in Amerindians reveals signatures of strong purifying selection shaping the centromeric KIR region.

Molecular Biology and Evolution
Luciana de Brito VargasDanillo G Augusto
October 9, 2021

Advances in immune therapies in hematological malignancies.

Journal of Internal Medicine
Luca MazzarellaMats Jerkeman
October 5, 2021

Emerging roles of suppressor of cytokine signaling 3 in human cancers.

Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie
Lirui DaiXinjun Wang
October 1, 2021
Open Access

Rapid Characterization of Complex Killer Cell Immunoglobulin-Like Receptor (KIR) Regions Using Cas9 Enrichment and Nanopore Sequencing.

Frontiers in Immunology
Jesse BruijnesteijnRonald E Bontrop
September 25, 2021

Altered effect of killer immunoglobulin-like receptor-ligand mismatch by graft versus host disease prophylaxis in cord blood transplantation.

Bone Marrow Transplantation
Hisayuki YokoyamaSatoko Morishima
September 14, 2021
Open Access

New Evidence in the Pathogenesis of Celiac Disease and Type 1 Diabetes Mellitus: A Systematic Review.

Jose PrietoLubna Mohammed
September 10, 2021

Killer-cell immunoglobulin-like receptor/human leukocyte antigen-C combination and 'great obstetrical syndromes' (Review).

Experimental and Therapeutic Medicine
Xiuhua Yang, Tao Meng
September 10, 2021
Open Access

Inhibitory Receptors and Immune Checkpoints Regulating Natural Killer Cell Responses to Cancer.

Irina Buckle, Camille Guillerey
September 5, 2021

Killer cell immunoglobulin-like receptor (KIR) gene distribution and allograft kidney function.

International Journal of Clinical Practice
Ertugrul ErkenEren Erken
September 4, 2021
Open Access

KIRCLE: An Analysis of Variations in KIR Genes in The Cancer Genome Atlas and UK Biobank

BioRxiv : the Preprint Server for Biology
G. F. GaoBo Li
September 3, 2021

Killer immunoglobulin-like receptor 2DS5 is associated with recovery from coronavirus disease 2019.

Intensive Care Medicine Experimental
Vadim LesanTorben Rixecker
September 1, 2021

HLA-C and KIR permutations influence chronic obstructive pulmonary disease risk.

JCI Insight
Takudzwa MkorombindoSteven R Duncan
August 26, 2021

KIR3DL1 Allotype-Dependent Modulation of NK Cell Immunity against Chronic Myeloid Leukemia.

Kiyotaka IzumiAkifumi Takaori-Kondo

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