Genomic Instability & Aging

During aging, it has been shown that genomic instability increases. This leads to mutations, cellular dysfunction, mitochondrial DNA damage, which may increase the risk for neurodegenerative disorders such as Alzheimer’s disease, Parkinson’s disease and ALS. Here is the latest research on genomic instability associated with aging.

January 16, 2022
Open Access

A mutation in transmembrane protein 135 impairs lipid metabolism in mouse eyecups.

Scientific Reports
Michael LandowskiAkihiro Ikeda
January 16, 2022
Open Access

ECCsplorer: a pipeline to detect extrachromosomal circular DNA (eccDNA) from next-generation sequencing data.

BMC Bioinformatics
Ludwig MannTony Heitkam
January 15, 2022
Preprint
Open Access

Mechanisms of A-type lamin targeting to nuclear ruptures are disrupted in LMNA- and BANF1- associated progerias

BioRxiv : the Preprint Server for Biology
R. M. Sears, Kyle J Roux
January 15, 2022

Contribution of Age, Brain Region, Mood Disorder Pathology, and Interindividual Factors on the Methylome of Human Microglia.

Biological Psychiatry
Lot D de WitteFatemeh Haghighi
January 15, 2022
Open Access

Lifespan prolonging mechanisms and insulin upregulation without fat accumulation in long-lived reproductives of a higher termite.

Communications Biology
Sarah SéitéMireille Vasseur-Cognet
January 15, 2022
Open Access

DunedinPACE, a DNA methylation biomarker of the pace of aging.

ELife
Daniel W BelskyTerrie E Moffitt
January 14, 2022
Preprint
Open Access

DNA methylation meta-analysis confirms the division of the genome into two functional groups

BioRxiv : the Preprint Server for Biology
Lev SalnikovE. Pinsky
January 14, 2022
Open Access

Epigenetic scores for the circulating proteome as tools for disease prediction.

ELife
Danni A GaddRiccardo E Marioni
January 14, 2022

The Genes Involved in Dentinogenesis.

Organogenesis
Shuang ChenShangfeng Liu
January 14, 2022

Hypophosphorylated pRb knock-in mice exhibit hallmarks of aging and vitamin C-preventable diabetes.

The EMBO Journal
Zhe JiangEldad Zacksenhaus
January 14, 2022

Biomarker-Driven Analysis Using High-Throughput Approaches in Neuroinflammation and Neurodegenerative Diseases.

Advances in Experimental Medicine and Biology
Marios G Krokidis
January 12, 2022
Preprint
Open Access

Rare Genetic Variants Correlate with Better Processing Speed

BioRxiv : the Preprint Server for Biology
Zeyuan SongP. Sebastiani
January 13, 2022

Age influences on the molecular presentation of tumours.

Nature Communications
Constance H LiPaul C Boutros
January 13, 2022

[Adrenal glands stem cells: general signaling pathways].

Problemy e̊ndokrinologii
O V GlazovaP Y Volchkov
January 13, 2022

The metabolome as a biomarker of aging in Drosophila melanogaster.

Aging Cell
Xiaqing ZhaoDaniel E L Promislow
January 12, 2022
Open Access

Retrotransposons Down- and Up-Regulation in Aging Somatic Tissues.

Cells
Giorgia GiordaniDavide Andrenacci
January 12, 2022
Review
Open Access

The Impact of Exercise on Telomere Length, DNA Methylation and Metabolic Footprints.

Cells
Sandra HauptOthmar Moser

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