Genomic Instability & Aging

During aging, it has been shown that genomic instability increases. This leads to mutations, cellular dysfunction, mitochondrial DNA damage, which may increase the risk for neurodegenerative disorders such as Alzheimer’s disease, Parkinson’s disease and ALS. Here is the latest research on genomic instability associated with aging.

January 11, 2021

Genes and pathways involved in senescence bypass identified by functional genetic screens

Mechanisms of Ageing and Development
Eugenia RoupakiaEvangelos Kolettas
January 16, 2021
Open Access

The impact of adjusting for baseline in pharmacogenomic genome-wide association studies of quantitative change

NPJ Genomic Medicine
Akinyemi Oni-OrisanThomas J Hoffmann
January 9, 2021
Open Access

Exifone Is a Potent HDAC1 Activator with Neuroprotective Activity in Human Neuronal Models of Neurodegeneration

ACS Chemical Neuroscience
Debasis PatnaikStephen J Haggarty
January 12, 2021
Preprint
Open Access

Reverse causal effect of atrial fibrillation on 17 site-specific cancer risk: A Mendelian randomization study

MedRxiv : the Preprint Server for Health Sciences
S. ParkDong Ki Kim
January 8, 2021
Open Access

A genome-wide CRISPR-based screen identifies KAT7 as a driver of cellular senescence

Science Translational Medicine
Wei WangGuang-Hui Liu
January 9, 2021
Review
Open Access

Role of Sirtuins in Modulating Neurodegeneration of the Enteric Nervous System and Central Nervous System

Frontiers in Neuroscience
Pavithra ChandramowlishwaranShanthi Srinivasan
January 11, 2021

The Single-Cell Gel Electrophoresis Genotoxin Sensitivity Assay

Methods in Molecular Biology
Franziska FerkSiegfried Knasmueller
January 7, 2021

A concise review of telomere and telomerase-related genetic markers in fibrotic lung diseases

Zhonghua lao dong wei sheng zhi ye bing za zhi = Zhonghua laodong weisheng zhiyebing zazhi = Chinese journal of industrial hygiene and occupational diseases
Y L Fan, Q Ye
January 8, 2021
Open Access

Type 2 diabetes mellitus-associated transcriptome alterations in cortical neurones and associated neurovascular unit cells in the ageing brain

Acta Neuropathologica Communications
Joanna J BuryCognitive Function and Ageing Study
January 5, 2021
Review
Open Access

Senescence and Apoptosis During in vitro Embryo Development in a Bovine Model

Frontiers in Cell and Developmental Biology
Priscila Ramos-IbeasEnrique Gómez
January 7, 2021
Open Access

Signature changes in the expressions of protein-coding genes, lncRNAs, and repeat elements in early and late cellular senescence

Turkish Journal of Biology = Türk Biyoloji Dergisi
Gökhan KarakÜlah, Cihangir Yandim
January 14, 2021
Preprint
Open Access

MLH1/3 variants causing aneuploidy, pregnancy loss, and premature reproductive aging

BioRxiv : the Preprint Server for Biology
R. FragozaJohn C. Schimenti

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