Germinal Centers

Geminal centres are located within secondary lymphoid organs including the spleen where B cell proliferation, differentiation, and antibody class-switching occurs. Here is the latest research.

January 19, 2022

The Idd2 Locus Confers Prominent Resistance to Autoimmune Diabetes.

The Journal of Immunology : Official Journal of the American Association of Immunologists
Félix Lombard-VadnaisSylvie Lesage
January 19, 2022

Phenotypic Drift in Lupus-Prone MRL/lpr Mice: Potential Roles of MicroRNAs and Gut Microbiota.

ImmunoHorizons
Xavier Cabana-PuigXin M Luo
January 16, 2022

Preliminary nonclinical safety and immunogenicity of an rVSV-ΔG-SARS-CoV-2-S vaccine in mice, hamsters, rabbits and pigs.

Archives of Toxicology
Noa Madar-BalakirskiHadar Marcus
January 15, 2022

Cell2location maps fine-grained cell types in spatial transcriptomics.

Nature Biotechnology
Vitalii KleshchevnikovOmer Ali Bayraktar
January 15, 2022

Cell-of-origin classification using the Hans and Lymph2Cx algorithms in primary cutaneous large B-cell lymphomas.

Virchows Archiv : an International Journal of Pathology
Anne M R SchraderJoost S P Vermaat
January 14, 2022

Comparative transcriptome profiles of Schistosoma japonicum larval stages: Implications for parasite biology and host invasion.

PLoS Neglected Tropical Diseases
Shaoyun ChengWei Hu
January 14, 2022
Review

The Possible Pathogenic Role of IgG4-Producing Plasmablasts in Stricturing Crohn's Disease.

Pathobiology : Journal of Immunopathology, Molecular and Cellular Biology
Omar BusharaGuang-Yu Yang
January 14, 2022
Review

The follicular lymphoma epigenome regulates its microenvironment.

Journal of Experimental & Clinical Cancer Research : CR
Rada Amin, Mounia S Braza
January 13, 2022
Review

Features of B Cell Responses Relevant to Allergic Disease.

The Journal of Immunology : Official Journal of the American Association of Immunologists
Christopher D C Allen
January 13, 2022

T-independent antigen induces humoral memory through germinal centers.

The Journal of Experimental Medicine
Xin LiuHai Qi
January 8, 2022

A new perspective is needed for positive selection of germinal center B cells with higher-affinity B cell receptors.

Cellular & Molecular Immunology
Timo Gaber, Frank Buttgereit
January 8, 2022
Review

Mitigating Covid-19 in the face of emerging virus variants, breakthrough infections and vaccine hesitancy.

Journal of Autoimmunity
Azizul Haque, Anudeep B Pant
January 7, 2022

A self-amplifying mRNA SARS-CoV-2 vaccine candidate induces safe and robust protective immunity in preclinical models.

Molecular Therapy : the Journal of the American Society of Gene Therapy
Giulietta MaruggiDong Yu
January 6, 2022
Preprint
Open Access

IKKalpha-Mediated Non-canonical NF-kappaB Signaling is Required to Support Murine Gammaherpesvirus 68 Latency In Vivo

BioRxiv : the Preprint Server for Biology
B. CieniewiczLaurie T Krug

Sign up to follow this feed and discover related papers.

Related Feeds

Antibodies: Agglutination

Antibody-mediated agglutination is the clumping of cells in the presence of antibody, which binds multiple cells together. This enhances the clearance of pathogens. Find the latest research on antibody-mediated agglutination here.

Antibodies: Complement Activation

The complement system can be activated by antigen-associated antibody. In the classical pathway of complement activation, C1q, C4b, and C3b are all able to bind to the Fc portion of IgG or IgM. Find the latest research on antibodies and complement activation here.

Antibody Development

Development of antibodies require integration of knowledge with respect to target antigen properties, antibody design criteria such as affinity, isotype selection, Fc domain engineering, and antibody cross-reactivity across species from the early stages of antibody development. Here is the latest research.


Antibody Specificity

Antibodies produced by B cells are highly specific for antigen as a result of random gene recombination and somatic hypermutation and affinity maturation. As the main effector of the humoral immune system, antibodies can neutralize foreign cells. Find the latest research on antibody specificity here.

Antibody synthesis

Antibodies have various functions including neutralization of pathogens, tumor targeting, as well as its utility in biomedical research. Here is the latest research on antibody synthesis.

Antibody-Dependent Cell Cytotoxicity

Antibody-dependent cellular toxicity refers to the lysis of a target cell by a non-sensitized effector cell of the immune system as a result of antibodies binding to the target cell membrane and engaging the Fc receptors on the immune effector cells. Find the latest research on antibody-dependent cellular toxicity here.

Antibody-Dependent Enhancement

Antibody-dependent enhancement of viral infection is the entry of virus into host cells mediated by antiviral antibodies interacting with Fc or complement receptors. This has been most extensively observed with the dengue virus. Find the latest research on antibody-dependent enhancement here.

Antigenic Modulation

Antigenic modulation occurs when an antibody cross-links antigens on a cell surface, causing the antigens to become internalized. This can lead to therapeutic failure of monoclonal antibodies as the expression of the antigen becomes decreased on target cells. Find the latest research on antigenic modulation here.

B cell Activation

B cell activation is initiated by the ligation of the B cell receptor with antigen and ultimately results in the production of protective antibodies against potentially pathogenic invaders. Here is the latest research.

B cell Differentiation

Depending on the signal received through the B cell receptor and other receptors, B cells differentiate into follicular or marginal zone B cells. Here is the latest research pertaining to this differentiation process.

© 2022 Meta ULC. All rights reserved
/feed-previews/germinal-centers/fb862562-c8c8-4197-a37b-bfbcb62b3b8d