GPCRs & Homeostasis

GPCRs are membrane receptors implicated in the pathophysiology of various diseases. Several GPCRs, including GLP-1 receptor, glucagon receptor, and adiponectin receptor, are also involved in metabolic regulation and homeostasis. Here is the latest research.

January 15, 2021
Open Access

Proteostasis in dendritic cells is controlled by the PERK signaling axis independently of ATF4

Life Science Alliance
Andreia MendesPhilippe Pierre
January 8, 2021
Review

P2Y Receptors for Extracellular Nucleotides: Contributions to Cancer Progression and Therapeutic Implications

Biochemical Pharmacology
Lucas T WoodsGary A Weisman
January 10, 2021

Biliary diversion increases resting energy expenditure leading to decreased blood glucose level in mice with type 2 diabetes

Journal of Diabetes Investigation
Haixin YinXiaodong He
January 17, 2021

Rspo1-LGR4 axis in BMSCs protects bone against radiation-induced injury through the mTOR-dependent autophagy pathway

Journal of Cellular Physiology
Xiaodan ChenWeizhen Zhang
January 10, 2021
Open Access

GPR109A mediates the effects of hippuric acid on regulating osteoclastogenesis and bone resorption in mice

Communications Biology
Jin-Ran ChenOxana P Lazarenko
January 8, 2021

Activation of G Protein-Coupled Estrogen Receptor 1 Ameliorates Proximal Tubular Injury and Proteinuria in Dahl Salt-Sensitive Female Rats

American Journal of Physiology. Regulatory, Integrative and Comparative Physiology
Eman Y GoharCarmen De Miguel
January 20, 2021
Review

Butyrate in Energy Metabolism: There Is Still More to Learn

Trends in Endocrinology and Metabolism : TEM
Lin ZhangYulong Yin
January 2, 2021
Review
Open Access

NOX-Dependent Signaling Dysregulation in Severe COVID-19: Clues to Effective Treatments

Frontiers in Cellular and Infection Microbiology
Simona DamianoMariarosaria Santillo
January 15, 2021

Discovery of the First Druggable GPR52 Antagonist to Treat Huntington's Disease

Journal of Medicinal Chemistry
Hidetoshi Komatsu
January 3, 2021
Review

The endocannabinoid system in the adipose organ

Reviews in Endocrine & Metabolic Disorders
Kwang-Mook JungDaniele Piomelli
January 19, 2021

Muscle-specific TGR5 overexpression improves glucose clearance in glucose-intolerant mice

The Journal of Biological Chemistry
Takashi SasakiRyuichiro Sato
January 13, 2021
Review

ENDOCRINOLOGY IN PREGNANCY: Metabolic impact of bile acids in gestation

European Journal of Endocrinology
Hei Man FanCatherine Williamson
January 13, 2021
Open Access

Pharmacological chaperone action in humanized mouse models of MC4R-linked obesity

JCI Insight
Patricia RenéMichel Bouvier

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