GPCRs & Homeostasis

GPCRs are membrane receptors implicated in the pathophysiology of various diseases. Several GPCRs, including GLP-1 receptor, glucagon receptor, and adiponectin receptor, are also involved in metabolic regulation and homeostasis. Here is the latest research.

July 28, 2020

Novel anti-thrombotic mechanisms mediated by Mas receptor as result of balanced activities between the kallikrein/kinin and the renin-angiotensin systems

Pharmacological Research : the Official Journal of the Italian Pharmacological Society
Chao Fang, Alvin H Schmaier
July 15, 2020

Cyclocarya paliurus polysaccharides alleviate type 2 diabetic symptoms by modulating gut microbiota and short-chain fatty acids

Phytomedicine : International Journal of Phytotherapy and Phytopharmacology
Ye YaoDongsheng Wang
July 20, 2020

Evaluation of biased agonism mediated by dual agonists of the GLP-1 and glucagon receptors

Biochemical Pharmacology
Sanaz DarbalaeiDenise Wootten
July 22, 2020

Structural insights into probe-dependent positive allosterism of the GLP-1 receptor

Nature Chemical Biology
Ana B BuenoKyle W Sloop
July 14, 2020

The microbiome and cytosolic innate immune receptors

Immunological Reviews
Timur LiwinskiEran Elinav
July 14, 2020

Synthetic G protein-coupled bile acid receptor agonists and bile acids act via basolateral receptors in ileal and colonic mucosa

Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society
Iain R ToughHelen M Cox
July 30, 2020

Fighting diabetes mellitus: Pharmacological and non-pharmacological approaches

Current Pharmaceutical Design
Xin WangHelong Quan
July 11, 2020

What is on the horizon for type 2 diabetes pharmacotherapy? - An overview of the antidiabetic drug development pipeline

Expert Opinion on Drug Discovery
Karl Sebastian JohanssonMikkel Bring Christensen
July 23, 2020

Specialized pro-resolving lipid mediators in cardiovascular disease, diagnosis, and therapy

Advanced Drug Delivery Reviews
Alexander S Kim, Michael S Conte
July 19, 2020

Development and characterization of novel mouse monoclonal antibodies against chicken chemokine CC motif ligand 4

Veterinary Immunology and Immunopathology
Mingmin LuCharles Li
July 27, 2020
Open Access

A structural framework for unidirectional transport by a bacterial ABC exporter

Proceedings of the National Academy of Sciences of the United States of America
Chengcheng FanDouglas C Rees
July 21, 2020

Regulation of melanocortin-4-receptor (MC4R) expression by SNP rs17066842 is dependent on glucose concentration

European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology
Li QinDaniel J Müller
July 29, 2020
Open Access

The GPR40 full agonist SCO-267 improves liver parameters in a mouse model of nonalcoholic fatty liver disease without affecting glucose or body weight

The Journal of Pharmacology and Experimental Therapeutics
Mitsugi OokawaraYusuke Moritoh
July 31, 2020

15-keto-PGE2 acts as a biased/partial agonist to terminate PGE2 -evoked signaling

The Journal of Biological Chemistry
Suzu EndoHiromichi Fujino
July 20, 2020

G-protein coupled receptors involved in the resolution of inflammation: ligands and therapeutic perspectives

Mini Reviews in Medicinal Chemistry
Margherita MastromarinoMarcello Leopoldo
July 18, 2020

Effects of the patent ductus venosus on bile acid homeostasis in aryl hydrocarbon receptor (AhR)-null mice

Toxicology and Applied Pharmacology
Iván L CsanakyCurtis D Klaassen

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