HDR in Genome Engineering

Homology-directed repair (HDR) is a double-strand break repair pathway that can be exploited to modify genomes in many organisms. Researchers are now using the CRISPR-Cas system to control the specificity of HDR genome engineering techniques. Here is the latest research.

July 6, 2020
Preprint
Open Access

CRISPR-Cas9 integrates exogeneous sorting new recombinant DNA in the model tree Populus trichocarpa

BioRxiv : the Preprint Server for Biology
Ali MovahediQ. Zhuge
July 2, 2020
Open Access

DSS1 and ssDNA regulate oligomerization of BRCA2

Nucleic Acids Research
Hang Phuong LeJie Liu
July 1, 2020

High-efficiency nonhomologous insertion of a foreign gene into the herpes simplex virus genome

The Journal of General Virology
Yue GongWei Cun
June 6, 2020

Role of RS-1 derivatives in homology-directed repair at the human genome ATG5 locus

Archives of Pharmacal Research
In-Sook JeonJoong-Kook Choi
June 11, 2020

CRISPR-Cas12a exploits R-loop asymmetry to form double-strand breaks

ELife
Joshua C CofskyJennifer A Doudna
July 4, 2020
Open Access

Targeting NRF2, Regulator of Antioxidant System, to Sensitize Glioblastoma Neurosphere Cells to Radiation-Induced Oxidative Stress

Oxidative Medicine and Cellular Longevity
Paulo R D V GodoySiamak Haghdoost
June 26, 2020

Site-Directed Mutagenesis of Large Biosynthetic Gene Clusters via Oligonucleotide Recombineering and CRISPR/Cas9 Targeting

ACS Synthetic Biology
Jia Jia Zhang, Bradley S Moore
July 8, 2020
Review
Open Access

Therapeutic Editing of the TP53 Gene: Is CRISPR/Cas9 an Option?

Genes
Regina MirgayazovaEmil Bulatov
July 1, 2020
Open Access

Single-molecule dynamics of Dishevelled at the plasma membrane and Wnt pathway activation

Proceedings of the National Academy of Sciences of the United States of America
Wenzhe MaMarc W Kirschner
July 8, 2020
Review

Rad51 filament dynamics and its antagonistic modulators

Seminars in Cell & Developmental Biology
Alexander Carver, Xiaodong Zhang
June 17, 2020
Open Access

Disease-associated DNA2 nuclease-helicase protects cells from lethal chromosome under-replication

Nucleic Acids Research
Benoît FalquetUlrich Rass
July 1, 2020
Open Access

Efficient gene editing of human long-term hematopoietic stem cells validated by clonal tracking

Nature Biotechnology
Samuele FerrariLuigi Naldini
July 8, 2020

Targeted, efficient sequence insertion and replacement in rice

Nature Biotechnology
Yuming LuJian-Kang Zhu

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