HDR in Genome Engineering

Homology-directed repair (HDR) is a double-strand break repair pathway that can be exploited to modify genomes in many organisms. Researchers are now using the CRISPR-Cas system to control the specificity of HDR genome engineering techniques. Here is the latest research.

October 21, 2020

Polymerase δ promotes chromosomal rearrangements and imprecise double-strand break repair

Proceedings of the National Academy of Sciences of the United States of America
Jacob V LayerTovah A Day
October 18, 2020

Compromised repair of radiation-induced DNA double-strand breaks in Fanconi anemia fibroblasts in G2

DNA Repair
Sebastian ZahnreichHeinz Schmidberger
October 10, 2020

Inhibition of poly(ADP-ribose) polymerase induces synthetic lethality in BRIP1 deficient ovarian epithelial cells

Gynecologic Oncology
Marcia A CicconeKevin J McDonnell
October 5, 2020

Genome editing systems across yeast species

Current Opinion in Biotechnology
Zhiliang Yang, Mark Blenner
October 18, 2020
Open Access

Structural basis of Mfd-dependent transcription termination

Nucleic Acids Research
Jing ShiYu Feng
October 22, 2020

Extracting Transition Rates in Particle Tracking Using Analytical Diffusion Distribution Analysis

Biophysical Journal
Jochem N A VinkJohannes Hohlbein
October 21, 2020

Restoration of visual function in adult mice with an inherited retinal disease via adenine base editing

Nature Biomedical Engineering
Susie SuhKrzysztof Palczewski
October 14, 2020
Open Access

CRISPR/Cas-based precision genome editing via microhomology-mediated end joining (MMEJ)

Plant Biotechnology Journal
Tien Van VuJae-Yean Kim
October 14, 2020

Regulation of ALT-associated homology-directed repair by polyADP-ribosylation

Nature Structural & Molecular Biology
Song My HoangRoderick J O'Sullivan
October 23, 2020

Precise Genome Modification in Tomato Using an Improved Prime Editing System

Plant Biotechnology Journal
Yuming LuJian-Kang Zhu
October 25, 2020

Targeted CRISPR screening identifies PRMT5 as synthetic lethality combinatorial target with gemcitabine in pancreatic cancer cells

Proceedings of the National Academy of Sciences of the United States of America
Xiaolong WeiMazhar Adli
October 20, 2020
Open Access

Visualization of uracils created by APOBEC3A using UdgX shows colocalization with RPA at stalled replication forks

Nucleic Acids Research
Jessica A StewartAshok S Bhagwat
October 24, 2020

Progress Toward Zygotic and Germline Gene Drives in Mice

The CRISPR Journal
Chandran PfitznerPaul Q Thomas
October 24, 2020

Reactions to the National Academies/Royal Society Report on Heritable Human Genome Editing

The CRISPR Journal
Misha AngristKevin Davies
October 3, 2020

LRRC31 inhibits DNA repair and sensitizes breast cancer brain metastasis to radiation therapy

Nature Cell Biology
Yanke ChenJiangbing Zhou
October 4, 2020
Open Access

Mitotic cells can repair DNA double-strand breaks via a homology-directed pathway

Journal of Radiation Research
Yuki SakamotoHiroshi Tauchi

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