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Hereditary Cancer Syndromes

Hereditary Cancer Syndromes diagram by SINITAR, Shutterstock
SINITAR, Shutterstock

Hereditary cancer syndromes comprise 5% of all cancers and have an increased risk of early onset and of multiple or bilateral malignancies. Here is the latest research on hereditary cancer syndromes.

Top 20 most recent papers
Cancer Letters

Human papillomavirus insertions identify the PIM family of serine/threonine kinases as targetable driver genes in head and neck squamous cell carcinoma

Cancer LettersJanuary 21, 2020
Tatevik R BroutianMaura L Gillison
2
Annals of Oncology : Official Journal of the European Society for Medical Oncology

Genome-wide profiling of non-smoking-related lung cancer cells reveals common RB1 rearrangements associated with histopathologic transformation in EGFR-mutant tumors

Annals of Oncology : Official Journal of the European Society for Medical OncologyJanuary 22, 2020
E ProsM Sanchez-Cespedes
Journal for Immunotherapy of Cancer

Enhanced efficacy and limited systemic cytokine exposure with membrane-anchored interleukin-12 T-cell therapy in murine tumor models

Journal for Immunotherapy of CancerJanuary 22, 2020
Ling ZhangChristian S Hinrichs
Annals of Oncology : Official Journal of the European Society for Medical Oncology

Vemurafenib in non-small-cell lung cancer patients with BRAFV600 and BRAFnonV600 mutations

Annals of Oncology : Official Journal of the European Society for Medical OncologyJanuary 22, 2020
J MazieresJ Y Blay
PLoS Computational Biology

Between-tumor and within-tumor heterogeneity in invasive potential

PLoS Computational BiologyJanuary 22, 2020
Veena PadmanabanJoel S Bader
Nucleic Acids Research

HSF2BP negatively regulates homologous recombination in DNA interstrand crosslink repair

Nucleic Acids ResearchJanuary 22, 2020
Koichi SatoAlex N Zelensky
The Journal of Clinical Investigation

TTK inhibition radiosensitizes basal-like breast cancer through impaired homologous recombination

The Journal of Clinical InvestigationJanuary 22, 2020
Benjamin C ChandlerCorey Speers
Nature Communications

Mutational signatures in tumours induced by high and low energy radiation in Trp53 deficient mice

Nature CommunicationsJanuary 22, 2020
Yun Rose LiAllan Balmain
Nature Communications

Androgen deprivation upregulates SPINK1 expression and potentiates cellular plasticity in prostate cancer

Nature CommunicationsJanuary 22, 2020
Ritika TiwariBushra Ateeq
Cell Death & Disease

NEDD4L downregulates autophagy and cell growth by modulating ULK1 and a glutamine transporter

Cell Death & DiseaseJanuary 22, 2020
Dong-Eun LeeHeesun Cheong
Journal of Molecular and Cellular Cardiology

Transcriptome signature of ventricular arrhythmia in dilated cardiomyopathy reveals increased fibrosis and activated TP53

Journal of Molecular and Cellular CardiologyJanuary 21, 2020
Mary E HaywoodMatthew R G Taylor
1
bioRxiv

Deciphering the Signaling Network Landscape of Breast Cancer Improves Drug Sensitivity Prediction

bioRxivJanuary 21, 2020
Marco TognettiBernd Bodenmiller
Cell Cycle

The microtubule targeting agents eribulin and paclitaxel activate similar signaling pathways and induce cell death predominantly in a caspase-independent manner

Cell CycleJanuary 22, 2020
Lisa C HüsemannReiner U Jänicke
Journal of Cellular Physiology

Crizotinib sensitizes the erlotinib resistant HCC827GR5 cell line by influencing lysosomal function

Journal of Cellular PhysiologyJanuary 22, 2020
Nele Van Der SteenGodefridus J Peters
Life Science Alliance

Nup93 regulates breast tumor growth by modulating cell proliferation and actin cytoskeleton remodeling

Life Science AllianceJanuary 22, 2020
Simone BersiniMartin W Hetzer
Bioinformatics

sismonr: Simulation of In Silico Multi-Omic Networks with adjustable ploidy and post-transcriptional regulation in R

BioinformaticsJanuary 22, 2020
Olivia Angelin-BonnetMatthieu Vignes
Nature Biotechnology

Reconstructing kinase network topologies from phosphoproteomics data reveals cancer-associated rewiring

Nature BiotechnologyJanuary 22, 2020
Maruan HijaziPedro R Cutillas
PloS One

Two common disease-associated TYK2 variants impact exon splicing and TYK2 dosage

PloS OneJanuary 22, 2020
Zhi LiSandra Pellegrini
Cellular Physiology and Biochemistry : International Journal of Experimental Cellular Physiology, Biochemistry, and Pharmacology

Genistein Represses HOTAIR/Chromatin Remodeling Pathways to Suppress Kidney Cancer

Cellular Physiology and Biochemistry : International Journal of Experimental Cellular Physiology, Biochemistry, and PharmacologyJanuary 22, 2020
Mitsuho Imai-SumidaSoichiro Yamamura
Chest

Genetic risk factors for spontaneous pneumothorax in Birt-Hogg-Dubé syndrome

ChestJanuary 21, 2020
Elke C SattlerOrtrud K Steinlein
1

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