Hereditary Demyelinating Diseases of the CNS

Hereditary demyelinating diseases of the central nervous systems are caused primarily due to inherited genetic conditions. Examples include Alexander, Canavan, and Pelizaeus-Merzbacher diseases. Here is the latest research.

January 15, 2022

OCT4-induced oligodendrocyte progenitor cells promote remyelination and ameliorate disease.

Npj Regenerative Medicine
Wonjin YunSeungkwon You
January 15, 2022

Elderly patients with suspected Charcot-Marie-Tooth disease should be tested for the TTR gene for effective treatments.

Journal of Human Genetics
Takaki TaniguchiHiroshi Takashima
January 15, 2022

Chronic lithium administration in a mouse model for Krabbe disease.

JIMD Reports
Ambra Del GrossoMarco Cecchini
January 15, 2022
Case Report

Low donor chimerism may be sufficient to prevent demyelination in adrenoleukodystrophy.

JIMD Reports
Takahiro IkedaTakanori Yamagata
January 15, 2022

Relationship between blood-brain permeability and antibodies against aquaporins in neuromyelitis optica spectrum disorders and multiple sclerosis patients.

Neurologia i neurochirurgia polska
Michalina Jasiak-ZatońskaAlicja Kalinowska-Łyszczarz
January 14, 2022

Longitudinal analysis reveals high prevalence of Epstein-Barr virus associated with multiple sclerosis.

Kjetil BjornevikAlberto Ascherio
January 14, 2022

Central Nervous System Demyelination Related to Tumour Necrosis Factor Alpha Inhibitor.

Multiple Sclerosis Journal - Experimental, Translational and Clinical
Shin Yee Chey, Allan G Kermode
January 12, 2022
Open Access

Single-nucleus RNA-seq of normal-appearing brain regions in relapsing-remitting vs. secondary progressive multiple sclerosis

BioRxiv : the Preprint Server for Biology
Yasuyuki KiharaJ. Chun
January 12, 2022
Open Access

Abnormal Ca2+ Signals in Reactive Astrocytes as a Common Cause of Brain Diseases.

International Journal of Molecular Sciences
Schuichi KoizumiJunichi Nabekura
January 12, 2022
Open Access

Human iPSC-Derived Astrocytes: A Powerful Tool to Study Primary Astrocyte Dysfunction in the Pathogenesis of Rare Leukodystrophies.

International Journal of Molecular Sciences
Angela LanciottiElena Ambrosini
January 12, 2022
Open Access

Structures of the human peroxisomal fatty acid transporter ABCD1 in a lipid environment.

Communications Biology
Le Thi My LeAmer Alam
January 12, 2022
Case Report

COVID-Related Leukoencephalopathy: Unusual MRI Features and Comparability to Delayed Post Hypoxic Ischemic Encephalopathy.

Radiology Case Reports
Manzoor AhmedAbd Al Kareem Adi
January 10, 2022

Prion-like α-synuclein pathology in the brain of infants with Krabbe disease.

Brain : a Journal of Neurology
Christopher HattonDaniel Erskine

Sign up to follow this feed and discover related papers.

Related Feeds

3D Cellular Models of Brain and Neurodegeneration

Brain organoids are three-dimensional in vitro cellular models of the brain that can recapitulate many processes such as the neurodevelopment. In addition, these organoids can be combined with other cell types, such as neurons and astrocytes to study their interactions in assembloids. Disease processes can also be modeled by induced pluripotent stem cell-derived organoids and assembloids from patients with neurodegenerative disorders. Discover the latest research on the models here.


TAR DNA-binding protein 43 (TDP-43) is a pathological protein identified in sporadic Amyotrophic Lateral Sclerosis (ALS) and Frontotemporal Dementia (FTD). Here are the latest discoveries pertaining to TDP-43 and these diseases.

ALS: Genetics

Amyotrophic Lateral Sclerosis (ALS) is a progressive neurodegenerative disorder characterized by muscle weakness. ALS is a genetically heterogeneous disorder with several causative genes. Here are the latest discoveries pertaining to the genetics of this disease.

ALS: Pathogenic Mechanisms

Amyotrophic Lateral Sclerosis is a progressive neurodegenerative disorder characterized by muscle weakness. Here is the latest research investigating pathogenic mechanisms that underlie this genetically heterogeneous disorder.

ALS: Phenotypes

Amyotrophic Lateral Sclerosis (ALS) is a neurodegenerative disorder characterized phenotypically by progressive muscle weakness. Clinical phenotypes of ALS can be classified based on the pattern, level, and area of onset (e.g. bulbar, cervical, lumbar). Here is the latest research investigating phenotypes of ALS.

ALS: Prions

Prions are misfolded proteins which characterize several fatal neurodegenerative diseases. Prion-like mechanisms are associated with the pathogenesis of Amyotrophic Lateral Sclerosis (ALS). Here is the latest research on ALS and prions.

ALS: Stress Granules

Amyotrophic Lateral Sclerosis (ALS) is a neurodegenerative disease characterized by cytoplasmic protein aggregates within motor neurons. TDP-43 is an ALS-linked protein that is known to regulate splicing and storage of specific mRNAs into stress granules, which have been implicated in formation of ALS protein aggregates. Here is the latest research in this field.

ALS: Therapies

Amyotrophic Lateral Sclerosis (ALS) is associated with the death of neurons that control voluntary muscles. This feed followes the latest research into therapies for this progressive neurodegenerative disease.

Age-related Dementia

Dementias are a group of conditions, including Alzheimer's disease, vascular dementia, and frontotemporal dementia, characterized by deficiencies in cognitive abilities. Age-related dementia refers to dementias that occur in older individuals, usually 60+ years old, in contrast to early-onset dementia. Follow the latest research on age-related dementia here.

Alexander Disease

Alexander disease is a rare leukodystrophy caused by mutations in the astrocyte-specific intermediate filament protein glial fibrillary acidic protein (GFAP). Here is the latest research on this disease.

© 2022 Meta ULC. All rights reserved