Histone Deacetylases

Histone deacetylases (HDACs) are a class of chromatin modifying enzymes that remove specific acetyl groups from histones, allowing the histones to wrap DNA more tightly, thus leading to alterations in gene expression. Here is the latest research. 


September 21, 2021
Open Access

PCV2 targets cGAS to inhibit type I interferon induction to promote other DNA virus infection.

PLoS Pathogens
Zhenyu WangYong Huang
September 20, 2021
Open Access

Lack of MOF Decreases Susceptibility to Hypoxia and Promotes Multidrug Resistance in Hepatocellular Carcinoma via HIF-1α.

Frontiers in Cell and Developmental Biology
Meng WangXiangzhi Li
September 20, 2021
Review
Open Access

Roles of Histone Deacetylases in Acute Myeloid Leukemia With Fusion Proteins.

Frontiers in Oncology
Juan ZhangLi Yu
September 20, 2021

The protective effect of beta-hydroxybutyric acid on renal glomerular epithelial cells in adriamycin-induced injury.

American Journal of Translational Research
Ming-Yang ChangZhang-Suo Liu
September 20, 2021
Review

The protective effects of 17-β estradiol and SIRT1 against cardiac hypertrophy: a review.

Heart Failure Reviews
Zahra Hajializadeh, Mohammad Khaksari
September 18, 2021
Open Access

Iminodibenzyl induced redirected COX-2 activity inhibits breast cancer progression.

NPJ Breast Cancer
Harshit ShahVenkatachalem Sathish
September 18, 2021

Vulnerability of IDH1 mutant cancers to histone deacetylase inhibition via orthogonal suppression of DNA repair.

Molecular Cancer Research : MCR
Jonathan DowPeter M Glazer
September 18, 2021

Hypoxia-activated KDAC inhibitor: Taking a breath from untargeted therapy.

Cell Chemical Biology
Maximilian Staudt, Manfred Jung
September 17, 2021

Dual Inhibition of Histone Deacetylases and the Mechanistic Target of Rapamycin Promotes Apoptosis in Cell Line Models of Uveal Melanoma.

Investigative Ophthalmology & Visual Science
Ruchi P PatelRobert W Robey
September 17, 2021

Rational design and development of HDAC inhibitors for breast cancer treatment.

Current Pharmaceutical Design
Deepansh ModyVibha Gupta
September 17, 2021
Open Access

Synergistic Tumor Cytolysis by NK Cells in Combination With a Pan-HDAC Inhibitor, Panobinostat.

Frontiers in Immunology
Lukman O AfolabiXiaochun Wan

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