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Human Brain Cell: Single Cell Transcriptomes & DNA Methylomes

Human Brain Cell: Single Cell Transcriptomes & DNA Methylomes diagram by Wei-Chung Allen Lee et al.
Wei-Chung Allen Lee et al.

Single-cell analyses provide a better-resolved picture of complex biological processes and unmask heterogeneity found between cells. Here is the latest research employing single-cell transcriptomics and examining DNA methylomes in brain cells.

Top 20 most recent papers
Nature

The microbiota regulate neuronal function and fear extinction learning

NatureOctober 1, 2019
Coco ChuDavid Artis
1272
23
11
1
Nature

Organoid single-cell genomic atlas uncovers human-specific features of brain development

NatureOctober 1, 2019
Sabina KantonJ. Gray Camp
503
35
8
196
1
bioRxiv

Zonation-dependent single-endothelial cell transcriptomic changes in the aged brain

bioRxivOctober 10, 2019
Lei ZhaoHo Ko
5
3
Nature Genetics

Stalled developmental programs at the root of pediatric brain tumors

Nature GeneticsNovember 27, 2019
Selin JessaClaudia L. Kleinman
83
6
Nature Methods

Simultaneous profiling of 3D genome structure and DNA methylation in single human cells

Nature MethodsSeptember 11, 2019
Dong-Sung LeeJoseph R. Ecker
289
8
5
105
bioRxiv

northstar: leveraging cell atlases to identify healthy and neoplastic cells in transcriptomes from human tumors

bioRxivOctober 27, 2019
Fabio ZaniniStephen R. Quake
46
bioRxiv

Transposon expression in the Drosophila brain is driven by neighbouring genes and diversifies the neural transcriptome

bioRxivNovember 11, 2019
Christoph Daniel Treiber, Scott H Waddell
46
bioRxiv

Genome-wide DNA methylation analysis of heavy cannabis exposure in a New Zealand longitudinal cohort

bioRxivNovember 4, 2019
Amy J OsborneMartin A. Kennedy
11
bioRxiv

Cell type and cortex-specific RNA editing in single human neurons informs neuropsychiatric disorders

bioRxivNovember 14, 2019
Brendan Robert E. AnsellMelanie Bahlo
21
Cell

Stress-Induced Metabolic Disorder in Peripheral CD4+ T Cells Leads to Anxiety-like Behavior

CellOctober 31, 2019
Ke-Qi FanJin Jin
267
2
1
100
1
bioRxiv

Enhancing droplet-based single-nucleus RNA-seq resolution using the semi-supervised machine learning classifier DIEM

bioRxivSeptember 30, 2019
M Isabel ÁlvarezPäivi Pajukanta
16
4
bioRxiv

Expression profiling of single cells and patient cohorts identifies multiple immunosuppressive pathways and an altered natural killer cell phenotype in glioblastoma

bioRxivOctober 4, 2019
Helen J CloseErica B Wilson
16
bioRxiv

Single cell transcriptome profiling of the human alcohol-dependent brain

bioRxivSeptember 24, 2019
Eric BrennerRoy Dayne Mayfield
3
bioRxiv

Defining the adult hippocampal neural stem cell secretome: in vivo versus in vitro transcriptomic differences and their correlation to secreted protein levels

bioRxivSeptember 8, 2019
Jiyeon Kim DenningerElizabeth D Kirby
4
Proceedings of the National Academy of Sciences of the United States of America

Human iPSC-derived microglia assume a primary microglia-like state after transplantation into the neonatal mouse brain

Proceedings of the National Academy of Sciences of the United States of AmericaNovember 26, 2019
Devon S SvobodaRudolf Jaenisch
35
1
bioRxiv

Cord blood DNA methylome in newborns later diagnosed with autism spectrum disorder reflects early dysregulation of neurodevelopmental and X-linked genes

bioRxivNovember 21, 2019
Charles Edward MordauntJanine M LaSalle
22
bioRxiv

Single-cell-resolution transcriptome map of human, chimpanzee, bonobo, and macaque brains

bioRxivSeptember 10, 2019
Ekaterina KhrameevaPhilipp Khaitovich
86
29
bioRxiv

Probing glioblastoma and its microenvironment using single-nucleus and single-cell sequencing

bioRxivSeptember 19, 2019
Sen PengHarshil D Dhruv
8
4
bioRxiv

Single cell analysis of the effects of developmental lead (Pb) exposure on the hippocampus.

bioRxivNovember 29, 2019
Justin A. ColacinoKelly M. Bakulski
1
Nature Communications

Comparative analysis of squamate brains unveils multi-level variation in cerebellar architecture associated with locomotor specialization

Nature CommunicationsDecember 5, 2019
Simone MacrìNicolas Di-Poï

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