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Huntington’s Disease - HTT Structure & Function (MDS)

Huntington’s Disease - HTT Structure & Function (MDS) diagram by Swaminathan et al, Wikimedia
Swaminathan et al, Wikimedia

Huntington’s disease (HD) is a hereditary neurodegenerative disease caused by mutations in the HTT gene which encodes the huntingtin protein. HD is characterized by poor coordination and involuntary body movements. Here is the latest research on the structure and function of huntingtin.

Top 20 most recent papers
Proceedings of the National Academy of Sciences of the United States of America

Mutant huntingtin disrupts mitochondrial proteostasis by interacting with TIM23

Proceedings of the National Academy of Sciences of the United States of AmericaJuly 28, 2019
Svitlana YablonskaRobert M Friedlander
Human Molecular Genetics

Nemo-like Kinase Reduces Mutant Huntingtin Levels and Mitigates Huntington's Disease

Human Molecular GeneticsApril 4, 2020
Mali JiangWenzhen Duan
ACS Applied Materials & Interfaces

Selenium Nanoparticles as an Efficient Nanomedicine for the Therapy of Huntington's Disease

ACS Applied Materials & InterfacesSeptember 4, 2019
Wenshu CongChunying Chen
Science Translational Medicine

Astrocyte molecular signatures in Huntington's disease

Science Translational MedicineOctober 18, 2019
Blanca Diaz-CastroBaljit S Khakh
Movement Disorders Clinical Practice

Characterizing White Matter in Huntington's Disease

Movement Disorders Clinical PracticeJanuary 24, 2020
Sarah GregoryEdward J Wild
Frontiers in Immunology

Expression of Human Mutant Huntingtin Protein in Drosophila Hemocytes Impairs Immune Responses

Frontiers in ImmunologyNovember 5, 2019
Yu-Hsien LinMichal Zurovec
Frontiers in Molecular Biosciences

The Role of Post-translational Modifications on the Energy Landscape of Huntingtin N-Terminus

Frontiers in Molecular BiosciencesOctober 22, 2019
Havva YalincaAnnalisa Pastore
Journal of Korean Neurosurgical Society

An Optimization of AAV-82Q-Delivered Rat Model of Huntington's Disease

Journal of Korean Neurosurgical SocietyMarch 6, 2020
Kyoung-Ha SoYoung Seok Park
Brain Sciences

Therapeutic Advances for Huntington's Disease

Brain SciencesJanuary 17, 2020
Ashok KumarJong-Joo Kim

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