Huntington’s Disease: HTT Structure & Function

Huntington’s disease (HD) is a hereditary neurodegenerative disease caused by mutations in the HTT gene which encodes the huntingtin protein. HD is characterized by poor coordination and involuntary body movements. Here is the latest research on the structure and function of huntingtin.

December 17, 2020

Brain Bio-Energetic State Does Not Correlate to Muscle Mitochondrial Function in Huntington's Disease

Journal of Huntington's Disease
Marcus P J van DiemenGeert Jan Groeneveld
August 28, 2020
Open Access

Phase Transition of Huntingtin: Factors and Pathological Relevance

Frontiers in Genetics
Junsheng Yang, Xiaotong Yang
November 11, 2020
Open Access

Molecular Mechanisms Underlying Muscle Wasting in Huntington's Disease

International Journal of Molecular Sciences
Manuela Bozzi, Francesca Sciandra
January 13, 2021

Mutations causing Lopes-Maciel-Rodan Syndrome are huntingtin hypomorphs

Human Molecular Genetics
Roy JungIhn Sik Seong
October 3, 2020
Open Access

Cerebrospinal Fluid Levels of Prodynorphin-Derived Peptides Are Decreased in Huntington's Disease

Movement Disorders : Official Journal of the Movement Disorder Society
Mhd Rami Al ShweikiMarkus Otto
January 12, 2021
Open Access

Dysregulation of Neuronal Calcium Signaling via Store-Operated Channels in Huntington's Disease

Frontiers in Cell and Developmental Biology
Magdalena Czeredys
November 17, 2020
Open Access

Safety, Pharmacokinetics and Pharmacodynamics of SBT-020 in Patients with Early Stage Huntington's Disease, a two-part study

British Journal of Clinical Pharmacology
Marcus P J van DiemenGeert Jan Groeneveld
December 19, 2020
Open Access

Analysis of mutant and total huntingtin expression in Huntington's disease murine models

Scientific Reports
Valentina FodaleAlberto Bresciani
November 29, 2020
Open Access

Proenkephalin Decreases in Cerebrospinal Fluid with Symptom Progression of Huntington's Disease

Movement Disorders : Official Journal of the Movement Disorder Society
Valter NiemelaJimmy Sundblom
September 17, 2020

Huntingtin protein maintains balanced energetics in mouse cardiomyocytes

Nucleosides, Nucleotides & Nucleic Acids
Marta TomczykRyszard T Smolenski
December 8, 2020

Mitochondrial SIRT3 confers neuroprotection in Huntington's disease by regulation of oxidative challenges and mitochondrial dynamics

Free Radical Biology & Medicine
Luana NaiaA Cristina Rego
September 24, 2020
Open Access

Hypoxia induces the translocation of glucose transporter 1 to the plasma membrane in vascular endothelial cells

The Journal of Physiological Sciences : JPS
Abdullah Al MamunMotohiko Sato
September 1, 2020

Development of Antisense Oligonucleotide Gapmers for the Treatment of Huntington's Disease

Methods in Molecular Biology
Tejal Aslesh, Toshifumi Yokota
September 9, 2020

Inflammation in Huntington's disease: A few new twists on an old tale

Journal of Neuroimmunology
Priscila Aparecida Costa ValadãoAline Silva de Miranda
October 29, 2020
Open Access

Protein kinase CK2 alpha prime and alpha-synuclein constitute a key regulatory pathway in Huntington's disease

BioRxiv : the Preprint Server for Biology
D. YuRocio Gomez-Pastor
September 24, 2020

Proteasome Subunits Involved in Neurodegenerative Diseases

Archives of Medical Research
Iván Fernández-Cruz, Enrique Reynaud
September 18, 2020

Serine residues 13 and 16 are key modulators of mutant huntingtin induced toxicity in Drosophila.

Experimental Neurology
Megha ChatterjeeNamita Agrawal

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