Huntington’s Disease - HTT Structure & Function

Huntington’s disease (HD) is a hereditary neurodegenerative disease caused by mutations in the HTT gene which encodes the huntingtin protein. HD is characterized by poor coordination and involuntary body movements. Here is the latest research on the structure and function of huntingtin.

July 14, 2020

Therapeutic strategies for Huntington's disease

Current Opinion in Neurology
Carlos Estevez-FragaS. J. Tabrizi
July 27, 2020
Review

Therapeutic Update on Huntington's Disease: Symptomatic Treatments and Emerging Disease-Modifying Therapies

Neurotherapeutics : the Journal of the American Society for Experimental NeuroTherapeutics
Deepa Dash, Tiago A Mestre
July 25, 2020
Preprint
Open Access

Huntingtin lowering reduces somatic instability at CAG-expanded loci

BioRxiv : the Preprint Server for Biology
S. R. CoffeyJeffrey B. Carroll
June 26, 2020
Open Access

Huntingtin-Associated Protein 1 in Mouse Hypothalamus Stabilizes Glucocorticoid Receptor in Stress Response

Frontiers in Cellular Neuroscience
Xingxing ChenXiao-Jiang Li
July 1, 2020

In Vivo Quantification of Protein Turnover in Aging C. Elegans using Photoconvertible Dendra2

Journal of Visualized Experiments : JoVE
Maria Lucia Pigazzini, Janine Kirstein
July 14, 2020
Comment / Editorial
Open Access

AAV5-miHTT gene therapy for Huntington disease: lowering both huntingtins

Expert Opinion on Biological Therapy
Melvin M Evers, Pavlina Konstantinova
July 16, 2020
Open Access

The Cdc48 Complex Alleviates the Cytotoxicity of Misfolded Proteins by Regulating Ubiquitin Homeostasis

Cell Reports
Ryan HigginsYanchang Wang
July 6, 2020
Correction
Open Access

Cysteamine Protects Neurons from Mutant Huntingtin Toxicity

Journal of Huntington's Disease
August 5, 2020

Loss of Hap1 selectively promotes striatal degeneration in Huntington disease mice

Proceedings of the National Academy of Sciences of the United States of America
Qiong LiuXiao-Jiang Li
August 4, 2020

Frequency of the loss of CAA interruption in the HTT CAG tract and implications for Huntington disease in the reduced penetrance range

Genetics in Medicine : Official Journal of the American College of Medical Genetics
Hailey Findlay BlackMichael R Hayden
July 1, 2020

Improvement in HLA-C typing by a new sequence-specific oligonucleotides kit

HLA : Immune Response Genetics
Marine CargouJonathan Visentin
July 28, 2020
Review
Open Access

Endosomal-Lysosomal Processing of Neurodegeneration-Associated Proteins in Astrocytes

International Journal of Molecular Sciences
Ching-On Wong
August 11, 2020
Open Access

Screening for the C9ORF72 expansion in Greek Huntington Disease phenocopies and controls and meta-analysis of current data

Tremor and Other Hyperkinetic Movements
Dimitrios RikosGeorgia Xiromerisiou
July 9, 2020
Open Access

Chronic Corticosterone Elevation Suppresses Adult Hippocampal Neurogenesis by Hyperphosphorylating Huntingtin

Cell Reports
Fabienne AgasseSandrine Humbert
June 21, 2020
Review
Open Access

How Do Post-Translational Modifications Influence the Pathomechanistic Landscape of Huntington's Disease? A Comprehensive Review

International Journal of Molecular Sciences
Beata LontayKrisztina Tar
July 1, 2020

Striatal connectivity in pre-manifest Huntington's disease is differentially affected by disease burden

European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies
L PiniC Jacquemot
August 6, 2020
Open Access

DNA Methyltransferase 1 (DNMT1) Acts on Neurodegeneration by Modulating Proteostasis-Relevant Intracellular Processes

International Journal of Molecular Sciences
Cathrin BayerGeraldine Zimmer-Bensch

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