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Huntington’s Disease Genetics

Huntington’s Disease Genetics diagram by Blamb, Shutterstock
Blamb, Shutterstock

Huntington’s disease (HD) is a hereditary neurodegenerative disease caused by mutations in the HTT gene which encodes the huntingtin protein. HD is characterized by poor coordination and involuntary body movements. Here is the latest research on the structure and function of huntingtin.

Top 20 most recent papers
Neural Regeneration Research

Emotion recognition and inhibitory control in manifest and pre-manifest Huntington's disease: evidence from a new Stroop task

Neural Regeneration ResearchJanuary 31, 2020
Thomas HunefeldtMarta Olivetti Belardinelli
1
99
4
3
46
Nature Protocols

Investigating RNA editing in deep transcriptome datasets with REDItools and REDIportal

Nature ProtocolsJanuary 31, 2020
Claudio Lo GiudiceErnesto Picardi
7
ACS Applied Materials & Interfaces

Selenium Nanoparticles as an Efficient Nanomedicine for the Therapy of Huntington's Disease

ACS Applied Materials & InterfacesSeptember 4, 2019
Wenshu CongChunying Chen
8
1
13
bioRxiv

cGAS, a DNA Sensor, Promotes Inflammatory Responses in Huntington Disease

bioRxivJanuary 9, 2020
Manish SharmaSrinivasa Subramaniam
5
Brain : a Journal of Neurology

MSH3 modifies somatic instability and disease severity in Huntington's and myotonic dystrophy type 1

Brain : a Journal of NeurologyJune 20, 2019
Michael FlowerSarah J Tabrizi
25
1
1
37
Nucleic Acids Research

Profiling the genome-wide landscape of tandem repeat expansions

Nucleic Acids ResearchJune 14, 2019
Nima MousaviMelissa Gymrek
16
60
Neurotherapeutics : the Journal of the American Society for Experimental NeuroTherapeutics

DNA Damage Repair in Huntington's Disease and Other Neurodegenerative Diseases

Neurotherapeutics : the Journal of the American Society for Experimental NeuroTherapeuticsAugust 1, 2019
T MaiuriR Truant
14
1
17
Cold Spring Harbor Perspectives in Biology

Calcium-Handling Defects and Neurodegenerative Disease

Cold Spring Harbor Perspectives in BiologyAugust 21, 2019
Sean SchrankGrace E Stutzmann
2
1
8
Brain : a Journal of Neurology

CYP46A1 gene therapy deciphers the role of brain cholesterol metabolism in Huntington's disease

Brain : a Journal of NeurologyJuly 10, 2019
Radhia KacherSandrine Betuing
17
2
25
3
Journal of Neuroinflammation

Unique molecular signature in mucolipidosis type IV microglia

Journal of NeuroinflammationDecember 31, 2019
Antony CougnouxForbes D Porter
4

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