Huntington’s Disease Genetics

Huntington’s disease (HD) is a hereditary neurodegenerative disease caused by mutations in the HTT gene which encodes the huntingtin protein. HD is characterized by poor coordination and involuntary body movements. Here is the latest research on the structure and function of huntingtin.

August 20, 2019

A miRNome analysis of drug-free manic psychotic bipolar patients versus healthy controls

European Archives of Psychiatry and Clinical Neuroscience
Silvia TabanoMassimiliano Buoli
May 23, 2019
Preprint
Open Access

Circulating bacterial DNA as a tool towards non-invasive biomarkers for colorectal cancer and adenoma

BioRxiv : the Preprint Server for Biology
Qian XiaoKefeng Ding
September 4, 2019
Open Access

Selenium Nanoparticles as an Efficient Nanomedicine for the Therapy of Huntington's Disease

ACS Applied Materials & Interfaces
Wenshu CongChunying Chen
July 10, 2019
Open Access

CYP46A1 gene therapy deciphers the role of brain cholesterol metabolism in Huntington's disease

Brain : a Journal of Neurology
Radhia KacherSandrine Betuing
December 16, 2019
Review

Epigenetic mechanisms of neurodegenerative diseases and acute brain injury

Neurochemistry International
Mario J BertogliatRaghu Vemuganti
August 1, 2019
Review

DNA Damage Repair in Huntington's Disease and Other Neurodegenerative Diseases

Neurotherapeutics : the Journal of the American Society for Experimental NeuroTherapeutics
T MaiuriR Truant
April 10, 2020

Huntington's Disease: Genome-wide Neuroprotection Screening Goes Viral

Neuron
C Y Daniel Lee, X William Yang
February 24, 2020

Genetic Risk Underlying Psychiatric and Cognitive Symptoms in Huntington's Disease

Biological Psychiatry
Natalie EllisPeter Holmans
August 10, 2019

CAG Repeat Not Polyglutamine Length Determines Timing of Huntington's Disease Onset

Cell
Genetic Modifiers of Huntington’s Disease (GeM-HD) Consortium. Electronic address: gusella@helix.mgh.harvard.edu, Genetic Modifiers of Huntington’s Disease (GeM-HD) Consortium
June 14, 2020
Open Access

Transcriptome Profiling Reveals Novel Candidate Genes Related to Hippocampal Dysfunction in SREBP-1c Knockout Mice

International Journal of Molecular Sciences
Mary Jasmin AngChangjong Moon
May 2, 2020
Review
Open Access

How Have Advances in Genetic Technology Modified Movement Disorders Nosology?

European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies
Andrea SturchioAlberto J Espay
April 5, 2020
Review
Open Access

Role of Connexins 30, 36, and 43 in Brain Tumors, Neurodegenerative Diseases, and Neuroprotection

Cells
Oscar F SánchezSonia-Luz Albarracin
May 2, 2019
Open Access

Hdac4 Interactions in Huntington's Disease Viewed Through the Prism of Multiomics

Molecular & Cellular Proteomics : MCP
Joel D FederspielIleana M Cristea
January 31, 2020

Investigating RNA editing in deep transcriptome datasets with REDItools and REDIportal

Nature Protocols
Claudio Lo GiudiceErnesto Picardi
November 7, 2019
Open Access

Treatment with JQ1, a BET bromodomain inhibitor, is selectively detrimental to R6/2 Huntington's disease mice

Human Molecular Genetics
Amanda J KedaigleLeslie M Thompson
August 7, 2019
Review

Alternative Splicing of ALS Genes: Misregulation and Potential Therapies

Cellular and Molecular Neurobiology
Benedetta PerroneSebastiano Cavallaro
April 24, 2019
Review

Next Generation Precision Medicine: CRISPR-mediated Genome Editing for the Treatment of Neurodegenerative Disorders

Journal of Neuroimmune Pharmacology : the Official Journal of the Society on NeuroImmune Pharmacology
Sudhanshu P RaikwarAsgar Zaheer
May 17, 2019
Preprint
Open Access

Genetic risk underlying psychiatric and cognitive symptoms in Huntington's Disease

BioRxiv : the Preprint Server for Biology
Natalie EllisPeter Holmans

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