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Huntington’s Disease Genetics

Huntington’s Disease Genetics diagram by Blamb, Shutterstock
Blamb, Shutterstock

Huntington’s disease (HD) is a hereditary neurodegenerative disease caused by mutations in the HTT gene which encodes the huntingtin protein. HD is characterized by poor coordination and involuntary body movements. Here is the latest research on the structure and function of huntingtin.

Top 20 most recent papers
Proceedings of the National Academy of Sciences of the United States of America

Early epigenomic and transcriptional changes reveal Elk-1 transcription factor as a therapeutic target in Huntington's disease

Proceedings of the National Academy of Sciences of the United States of AmericaNovember 21, 2019
Ferah YildirimErnest Fraenkel
7
1
4
Brain : a Journal of Neurology

MSH3 modifies somatic instability and disease severity in Huntington's and myotonic dystrophy type 1

Brain : a Journal of NeurologyJune 20, 2019
Michael FlowerSarah J Tabrizi
25
1
1
42
Nature Protocols

Investigating RNA editing in deep transcriptome datasets with REDItools and REDIportal

Nature ProtocolsJanuary 31, 2020
Claudio Lo GiudiceErnesto Picardi
7
Cell

CAG Repeat Not Polyglutamine Length Determines Timing of Huntington's Disease Onset

CellAugust 10, 2019
Genetic Modifiers of Huntington’s Disease (GeM-HD) Consortium. Electronic address: gusella@helix.mgh.harvard.edu, Genetic Modifiers of Huntington’s Disease (GeM-HD) Consortium
91
9
154
1
100
4
4
51
Biological Psychiatry

Genetic Risk Underlying Psychiatric and Cognitive Symptoms in Huntington's Disease

Biological PsychiatryFebruary 24, 2020
Natalie EllisPeter Holmans
4
1
1
ACS Applied Materials & Interfaces

Selenium Nanoparticles as an Efficient Nanomedicine for the Therapy of Huntington's Disease

ACS Applied Materials & InterfacesSeptember 4, 2019
Wenshu CongChunying Chen
8
1
14
Neurotherapeutics : the Journal of the American Society for Experimental NeuroTherapeutics

DNA Damage Repair in Huntington's Disease and Other Neurodegenerative Diseases

Neurotherapeutics : the Journal of the American Society for Experimental NeuroTherapeuticsAugust 1, 2019
T MaiuriR Truant
14
1
21
Nucleic Acids Research

Profiling the genome-wide landscape of tandem repeat expansions

Nucleic Acids ResearchJune 14, 2019
Nima MousaviMelissa Gymrek
16
60
Brain : a Journal of Neurology

CYP46A1 gene therapy deciphers the role of brain cholesterol metabolism in Huntington's disease

Brain : a Journal of NeurologyJuly 10, 2019
Radhia KacherSandrine Betuing
16
2
30
Neurochemistry International

Epigenetic mechanisms of neurodegenerative diseases and acute brain injury

Neurochemistry InternationalDecember 16, 2019
Mario J BertogliatRaghu Vemuganti
9
Journal of Neuroimmune Pharmacology : the Official Journal of the Society on NeuroImmune Pharmacology

Next Generation Precision Medicine: CRISPR-mediated Genome Editing for the Treatment of Neurodegenerative Disorders

Journal of Neuroimmune Pharmacology : the Official Journal of the Society on NeuroImmune PharmacologyApril 24, 2019
Sudhanshu P RaikwarAsgar Zaheer
10
31
Journal of Neuroinflammation

Unique molecular signature in mucolipidosis type IV microglia

Journal of NeuroinflammationDecember 31, 2019
Antony CougnouxForbes D Porter
4
Molecular & Cellular Proteomics : MCP

Hdac4 Interactions in Huntington's Disease Viewed Through the Prism of Multiomics

Molecular & Cellular Proteomics : MCPMay 2, 2019
Joel D FederspielIleana M Cristea
7
1
16

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