Huntington’s Disease: Genetics

Huntington’s disease (HD) is a hereditary neurodegenerative disease caused by mutations in the HTT gene, which encodes the huntingtin protein. HD is characterized by poor coordination and involuntary body movements. Here is the latest research on Huntington's disease genetics.

April 14, 2021
Preprint
Open Access

FAN1 nuclease activity affects CAG expansion and age at onset of Huntington's disease

BioRxiv : the Preprint Server for Biology
B. H. McAllisterThomas H Massey
April 14, 2021

Modulation of Huntington's disease in Drosophila.

CNS & Neurological Disorders Drug Targets
Iqra Subhan, Yasir Hasan Siddique
April 5, 2021

Converging evidence in support of omega-3 polyunsaturated fatty acids as a potential therapy for Huntington's disease symptoms.

Reviews in the Neurosciences
Owen M Vega, Carlos Cepeda
April 4, 2021
Review
Open Access

A Systematic Review of Genetic Polymorphisms Associated with Binge Eating Disorder.

Nutrients
Lucia ManfrediDavid Conversi
April 3, 2021
Open Access

An Australian Neuro-Palliative perspective on Huntington's disease: a case report.

BMC Palliative Care
Rajvi ShahChristopher Grossman
April 1, 2021

Geographic differences in the incidence of Huntington's disease in Sardinia, Italy.

Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology
Antonella MuroniGiovanni Defazio
March 30, 2021
Review
Open Access

Neurodegenerative Disease and the NLRP3 Inflammasome.

Frontiers in Pharmacology
Jonathan A HolbrookMichael F McDermott
March 27, 2021
Open Access

Spinocerebellar Ataxia Type 1 protein Ataxin-1 is signalled to DNA damage by Ataxia Telangiectasia Mutated kinase.

Human Molecular Genetics
Celeste SuartRay Truant
March 27, 2021
Open Access

Modulation of SETDB1 activity by APQ ameliorates heterochromatin condensation, motor function, and neuropathology in a Huntington's disease mouse model.

Journal of Enzyme Inhibition and Medicinal Chemistry
Yu Jin HwangSun-Joon Min
March 27, 2021

Role of older generations in the family's adjustment to Huntington disease.

Journal of Community Genetics
Carla Roma OliveiraLiliana Sousa
March 26, 2021

Population genetic variation of SLC6A4 gene, associated with neurophysiological development.

Journal of Genetics
Shyamala H HandeRanajit Das
March 23, 2021
Open Access

Ablation of kynurenine 3-monooxygenase rescues plasma inflammatory cytokine levels in the R6/2 mouse model of Huntington's disease.

Scientific Reports
Marie Katrin BondulichGillian P Bates
March 22, 2021
Review
Open Access

Tissue Microbiome Associated With Human Diseases by Whole Transcriptome Sequencing and 16S Metagenomics.

Frontiers in Genetics
Rana Salihoğlu, Tuğba Önal-Süzek
March 19, 2021
Open Access

On the hunt for a cure: A guide to Huntington disease.

JAAPA : Official Journal of the American Academy of Physician Assistants
Jennifer de la Cruz, Joseph Hwang
March 17, 2021

Predictors of Caregiver Burden in Huntington's Disease.

Archives of Clinical Neuropsychology : the Official Journal of the National Academy of Neuropsychologists
Danielle C Hergert, Cynthia R Cimino
March 14, 2021
Review
Open Access

Neurodegeneration and epigenetics: A review.

Neurología : publicación oficial de la Sociedad Española de Neurología
P Ghosh, A Saadat
March 14, 2021
Open Access

Transcriptional profiling reveals the transcription factor networks regulating the survival of striatal neurons.

Cell Death & Disease
Lin YangZhuangzhi Zhang

Sign up to follow this feed and discover related papers.

Related Feeds

3D Cellular Models of Brain and Neurodegeneration

Brain organoids are three-dimensional in vitro cellular models of the brain that can recapitulate many processes such as the neurodevelopment. In addition, these organoids can be combined with other cell types, such as neurons and astrocytes to study their interactions in assembloids. Disease processes can also be modeled by induced pluripotent stem cell-derived organoids and assembloids from patients with neurodegenerative disorders. Discover the latest research on the models here.

AAV-based Gene Therapy

Adeno-associated virus (AAV)-based gene therapy is a biological vector that is being researched to be used as a potential therapeutic option. This gene therapy is designed to insert fragments of DNA into targeted cells to help treat diseases, such as hemophilia a. Discover the latest research on AAV-based gene therapy here.

ALS & FTD: TDP-43

TAR DNA-binding protein 43 (TDP-43) is a pathological protein identified in sporadic Amyotrophic Lateral Sclerosis (ALS) and Frontotemporal Dementia (FTD). Here are the latest discoveries pertaining to TDP-43 and these diseases.

ALS: Genetics

Amyotrophic Lateral Sclerosis (ALS) is a progressive neurodegenerative disorder characterized by muscle weakness. ALS is a genetically heterogeneous disorder with several causative genes. Here are the latest discoveries pertaining to the genetics of this disease.

ALS: Pathogenic Mechanisms

Amyotrophic Lateral Sclerosis is a progressive neurodegenerative disorder characterized by muscle weakness. Here is the latest research investigating pathogenic mechanisms that underlie this genetically heterogeneous disorder.

ALS: Phenotypes

Amyotrophic Lateral Sclerosis (ALS) is a neurodegenerative disorder characterized phenotypically by progressive muscle weakness. Clinical phenotypes of ALS can be classified based on the pattern, level, and area of onset (e.g. bulbar, cervical, lumbar). Here is the latest research investigating phenotypes of ALS.

ALS: Prions

Prions are misfolded proteins which characterize several fatal neurodegenerative diseases. Prion-like mechanisms are associated with the pathogenesis of Amyotrophic Lateral Sclerosis (ALS). Here is the latest research on ALS and prions.

ALS: Stress Granules

Amyotrophic Lateral Sclerosis (ALS) is a neurodegenerative disease characterized by cytoplasmic protein aggregates within motor neurons. TDP-43 is an ALS-linked protein that is known to regulate splicing and storage of specific mRNAs into stress granules, which have been implicated in formation of ALS protein aggregates. Here is the latest research in this field.

ALS: Therapies

Amyotrophic Lateral Sclerosis (ALS) is associated with the death of neurons that control voluntary muscles. This feed followes the latest research into therapies for this progressive neurodegenerative disease.

Acute Myeloid Leukaemia & RNA

Acute myeloid leukaemia (AML) is a common hematological type of cancer. As the population ages, there has been a rise in the frequency of AML. RNA expression has been used to see if there are different genetic profiles that exist within AML and whether these may underpin the variations in survival rates. Here is the latest research on AML and RNA.

© 2021 Meta ULC. All rights reserved
/feed-previews/huntingtons-disease-genetics/80a34cca-e94e-4537-8208-27d3095519cf