Hutchinson-Gilford Progeria Syndrome

Hutchinson-gilford progeria syndrome is a very rare premature aging disorder that affects children, clinically mimicking physiological aging at a young age. The disease incidence is estimated at 1 in 18 million. Discover the latest research on Hutchinson-gilford progeria syndrome here.

October 10, 2020
Open Access

Lysophosphatidic Acid Receptors 2 and 3 Regulate Erythropoiesis at Different Hematopoietic Stages

Biochimica Et Biophysica Acta. Molecular and Cell Biology of Lipids
Jui-Chung ChiangHsinyu Lee
September 10, 2020
Preprint
Open Access

NLRP3 inflammasome inhibition rescues Hutchinson-Gilford Progeria cellular phenotype and extend longevity of an animal model

BioRxiv : the Preprint Server for Biology
E. Alcocer-GomezMario D. Cordero
September 3, 2020
Open Access

ZMPSTE24 Is Associated with Elevated Inflammation and Progerin mRNA

Cells
Moritz MessnerMarc-Michael Zaruba
August 21, 2020
Open Access

PRDM8 reveals aberrant DNA methylation in aging syndromes and is relevant for hematopoietic and neuronal differentiation

Clinical Epigenetics
Olivia CyprisWolfgang Wagner
November 25, 2020
Open Access

Decreased mechanotransduction prevents nuclear collapse in a Caenorhabditis elegans laminopathy

Proceedings of the National Academy of Sciences of the United States of America
Gabriela Huelgas-MoralesDavid Greenstein
September 14, 2020
Review

Sella turcica morphology in patients with genetic syndromes: a systematic review

Orthodontics & Craniofacial Research
Imaan A Roomaney, Manogari Chetty
September 3, 2020
Preprint
Open Access

Defining Substrate Requirements for Cleavage of Farnesylated Prelamin A by the Integral Membrane Zinc Metalloprotease ZMPSTE24

BioRxiv : the Preprint Server for Biology
K. M. WoodSusan Michaelis
January 8, 2021
Open Access

A genome-wide CRISPR-based screen identifies KAT7 as a driver of cellular senescence

Science Translational Medicine
Wei WangGuang-Hui Liu
January 8, 2021

In vivo base editing rescues Hutchinson-Gilford progeria syndrome in mice

Nature
Luke W KoblanDavid R Liu
September 18, 2020
Open Access

Multisystem Progeroid Syndrome With Lipodystrophy, Cardiomyopathy, and Nephropathy Due to an LMNA p.R349W Variant

Journal of the Endocrine Society
Iram HussainAbhimanyu Garg
October 10, 2020
Open Access

Heterozygous lamin B1 and lamin B2 variants cause primary microcephaly and define a novel laminopathy

Genetics in Medicine : Official Journal of the American College of Medical Genetics
David A ParryAndrew P Jackson
August 19, 2020
Open Access

Vulnerability of progeroid smooth muscle cells to biomechanical forces is mediated by MMP13

Nature Communications
Patricia R PitrezLino Ferreira
November 4, 2020
Open Access

ESCRT-III controls nuclear envelope deformation induced by progerin

Scientific Reports
Jun AriiYasushi Kawaguchi
August 28, 2020
Open Access

Using nuclear envelope mutations to explore age-related skeletal muscle weakness

Clinical Science
Edmund BatteyJulien Ochala

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