Hutchinson-Gilford Progeria Syndrome

Hutchinson-gilford progeria syndrome is a very rare premature aging disorder that affects children, clinically mimicking physiological aging at a young age. The disease incidence is estimated at 1 in 18 million. Discover the latest research on Hutchinson-gilford progeria syndrome here.

February 23, 2020
Open Access

Heterochromatin loss as a determinant of progerin-induced DNA damage in Hutchinson-Gilford Progeria

Aging Cell
Alexandre ChojnowskiOliver Dreesen
May 27, 2020
Open Access

Epigenetic deregulation of lamina-associated domains in Hutchinson-Gilford progeria syndrome

Genome Medicine
Florian KöhlerManuel Rodríguez-Paredes
April 24, 2020
Open Access

SIRT1 ameliorates premature senescence-induced defenestration in hepatic sinusoidal endothelial cell

BioRxiv : the Preprint Server for Biology
Bingyong ZhangX. Li
May 16, 2020
Open Access

Genotype-phenotype analysis of LMNA-related diseases predicts phenotype-selective alterations in lamin phosphorylation

FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology
Eric W LinM Bishr Omary
April 23, 2020
Open Access

Chromatin and Cytoskeletal Tethering Determine Nuclear Morphology in Progerin-Expressing Cells

Biophysical Journal
M. C. LionettiC. A. M. La Porta
April 17, 2020
Case Report

Hutchinson-Gilford Progeria syndrome: Report of the first Togolese case

American Journal of Medical Genetics. Part a
Koffi M GuedenonDidier K Gnamey
May 28, 2020
Open Access

Lamin A/C Mechanotransduction in Laminopathies

Francesca DonnalojaManuela Teresa Raimondi
April 24, 2020
Open Access

Vitamin C Treatment Rescues Prelamin A-Induced Premature Senescence of Subchondral Bone Mesenchymal Stem Cells

Stem Cells International
Yan-Nv QuXiao-Hua Xie
March 23, 2020

Ste24: An Integral Membrane Protein Zinc Metalloprotease with Provocative Structure and Emergent Biology

Journal of Molecular Biology
Brandon R Goblirsch, Michael C Wiener
March 17, 2020
Case Report

Anesthesia for a cesarean section on a pregnant patient with Cockayne syndrome: case report

Revista brasileira de anestesiologia
Viviane Barrada RibeiroRogério Luiz da Rocha Videira
March 3, 2020

Induced pluripotency and spontaneous reversal of cellular aging in supercentenarian donor cells

Biochemical and Biophysical Research Communications
Jieun LeeDana Larocca
March 21, 2020
Open Access

The JAK1/2 inhibitor ruxolitinib delays premature aging phenotypes

Aging Cell
Audrey GriveauDavid Bernard
May 15, 2020

Evaluation of musculoskeletal phenotype of the G608G progeria mouse model with lonafarnib, pravastatin, and zoledronic acid as treatment groups

Proceedings of the National Academy of Sciences of the United States of America
Maria B CubriaAra Nazarian
February 5, 2020
Open Access

Neuropeptide Y Enhances Progerin Clearance and Ameliorates the Senescent Phenotype of Human Hutchinson-Gilford Progeria Syndrome Cells

The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences
Célia A AveleiraCláudia Cavadas
May 27, 2020
Open Access

Paradoxical aortic stiffening and subsequent cardiac dysfunction in Hutchinson-Gilford progeria syndrome

Journal of the Royal Society, Interface
S-I MurtadaJ D Humphrey
May 4, 2020
Case Report

Hutchinson-Gilford progeria syndrome and severe aortic stenosis: a new hope for treatment

The Annals of Thoracic Surgery
Francesco MusumeciMauro Cassese

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