IL-6/JAK/STAT3 Pathway

The IL-6/JAK/STAT3 pathway is overactive in several cancer types. The increased activity of this pathway enhances tumor growth proliferation, survival and increases metastases of cancer cells. The target of the pathway to inhibit tumor growth is currently being explored. Here is the latest research on the IL-6/JAK/STAT3 pathway in cancer.

October 7, 2020
Open Access

G3BP1 controls the senescence-associated secretome and its impact on cancer progression

Nature Communications
Amr OmerImed-Eddine Gallouzi
September 1, 2020
Preprint
Open Access

Multi-modal pooled Perturb-CITE-Seq screens in patient models define novel mechanisms of cancer immune evasion

BioRxiv : the Preprint Server for Biology
C. J. FrangiehBenjamin Izar
October 8, 2020
Preprint
Open Access

Macrophages in Tumor-Associated Adipose Microenvironment Accelerate Tumor Progression

ResearchSquare
Bei LiShengrong Sun
September 18, 2020
Open Access

Raloxifene inhibits pancreatic adenocarcinoma growth by interfering with ERβ and IL-6/gp130/STAT3 signaling

Cellular Oncology (Dordrecht)
Ioannis PoziosHendrik Seeliger
September 26, 2020

Sodium propionate exerts anticancer effect in mice bearing breast cancer cell xenograft by regulating JAK2/STAT3/ROS/p38 MAPK signaling

Acta Pharmacologica Sinica
Hyun-Soo ParkChang-Seon Myung
October 8, 2020
Open Access

STAT3 Mediated miR-30a-5p Inhibition Enhances Proliferation and Inhibits Apoptosis in Colorectal Cancer Cells

International Journal of Molecular Sciences
Chun-Chia ChengChun-Chao Chang
September 3, 2020
Review
Open Access

STAT3, the Challenge for Chemotherapeutic and Radiotherapeutic Efficacy

Cancers
Ping-Lian YangLi-Yan Xu
September 4, 2020
Open Access

SH003 activates autophagic cell death by activating ATF4 and inhibiting G9a under hypoxia in gastric cancer cells

Cell Death & Disease
Tae Woo KimSeong-Gyu Ko
September 4, 2020
Review

STAT3 transcription factor as target for anti-cancer therapy

Pharmacological Reports : PR
Aliaa M MohassabMohamed Abdel-Aziz
September 2, 2020

NOK associates with c-Src and promotes c-Src-induced STAT3 activation and cell proliferation

Cellular Signalling
Yinyin WangBingtao Zhu
September 15, 2020

LINC00689 induces gastric cancer progression via modulating the miR-338-3p/HOXA3 axis

The Journal of Gene Medicine
Hui LuLiying Liu
September 11, 2020
Review
Open Access

Plant Extracts as Possible Agents for Sequela of Cancer Therapies and Cachexia

Antioxidants
Jinjoo LeeBonglee Kim
September 26, 2020
Open Access

Pimozide Suppresses the Growth of Brain Tumors by Targeting STAT3-Mediated Autophagy

Cells
Alok RanjanSanjay K Srivastava
September 30, 2020
Review
Open Access

Treatment of rheumatic immune-related adverse events due to cancer immunotherapy with immune checkpoint inhibitors-is it time for a paradigm shift?

Clinical Rheumatology
Katerina ChatzidionysiouAnca Catrina

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