IL-6/JAK/STAT3 Pathway

The IL-6/JAK/STAT3 pathway is overactive in several cancer types. The increased activity of this pathway enhances tumor growth proliferation, survival and increases metastases of cancer cells. The target of the pathway to inhibit tumor growth is currently being explored. Here is the latest research on the IL-6/JAK/STAT3 pathway in cancer.

July 2, 2020
Open Access

Novel Nanocomplexes Targeting STAT3 Demonstrate Promising Anti-Ovarian Cancer Effects in vivo

OncoTargets and Therapy
Xiaolei ZhangPeishu Liu
June 4, 2020

Expression profiles and function of IL6 in polymorphonuclear myeloid-derived suppressor cells

Cancer Immunology, Immunotherapy : CII
Mohammed L IbrahimKebin Liu
June 25, 2020

Iron in the Tumor Microenvironment

Advances in Experimental Medicine and Biology
Driton Vela
June 11, 2020

GBP2 enhances glioblastoma invasion through Stat3/fibronectin pathway

Shuye YuMing Li
May 22, 2020

Inhibiting effect of MicroRNA-3619-5p/PSMD10 axis on liver cancer cell growth in vivo and in vitro

Life Sciences
Peipei HaoYunpeng Wang
June 5, 2020
Open Access

Transcription activation of circ-STAT3 induced by Gli2 promotes the progression of hepatoblastoma via acting as a sponge for miR-29a/b/c-3p to upregulate STAT3/Gli2

Journal of Experimental & Clinical Cancer Research : CR
Yanfeng LiuXianqiang Wang
June 7, 2020
Open Access

Inhibitory Effects of Tangeretin, A Citrus Peel-Derived Flavonoid, on Breast Cancer Stem Cell Formation through Suppression of Stat3 Signaling

Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry
Yu-Chan KoDong-Sun Lee
July 1, 2020

Design, synthesis and biological evaluation of novel potent STAT3 inhibitors based on BBI608 for cancer therapy

European Journal of Medicinal Chemistry
Kai-Rui FengPing Tian
July 7, 2020
Open Access

Chaetocin Abrogates the Self-Renewal of Bladder Cancer Stem Cells via the Suppression of the KMT1A-GATA3-STAT3 Circuit

Frontiers in Cell and Developmental Biology
Zhao YangChangyuan Yu
May 28, 2020
Open Access

Trioxolone Methyl, a Novel Cyano Enone-Bearing 18βH-Glycyrrhetinic Acid Derivative, Ameliorates Dextran Sulphate Sodium-Induced Colitis in Mice

Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry
Andrey V MarkovMarina A Zenkova
July 7, 2020
Open Access

Molecular mechanism of gossypol mediating CCL2 and IL‑8 attenuation in triple‑negative breast cancer cells

Molecular Medicine Reports
Samia S MessehaKaram F A Soliman
May 22, 2020
Open Access

Targeting the HGF/MET Axis in Cancer Therapy: Challenges in Resistance and Opportunities for Improvement

Frontiers in Cell and Developmental Biology
Xing HuangTingbo Liang
June 18, 2020
Open Access

Regulation of heterogeneous cancer-associated fibroblasts: the molecular pathology of activated signaling pathways

Journal of Experimental & Clinical Cancer Research : CR
Go J Yoshida
June 19, 2020
Open Access

FBXO2 modulates STAT3 signaling to regulate proliferation and tumorigenicity of osteosarcoma cells

Cancer Cell International
Xunming ZhaoBiao Hu
July 3, 2020

Bispecific antibodies: a novel approach for targeting prominent biomarkers

Human Vaccines & Immunotherapeutics
Akshita Gupta, Yatender Kumar

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