Mapping the human immune system spatially, within and between tissues, will provide the basis for studying mechanisms of tissue residency and the effects of aging. This feed follos new studies profiling the immune system, including at different developmental stages.
The discovery of autophagy-related ('ATG') proteins in the 1990s greatly advanced the mechanistic understanding of autophagy and clarified the fact that autophagy serves important roles in various biological processes.
Examining the genomics, transcriptomics, proteomics, and metabolomics of adipose tissue at the single cell level will help build a single cell atlas of these tissues, providing insights into how changes in the map underlie health and disease states. Discover the latest research on adipose tissue heterogeneity here.
This feed focuses on the role of the aging process on developing diabetes.
Age is associated with many metabolic disorders including cardiovascular diseases, type 2 diabetes, stroke and heart disease. The mediators in aging process have been suggested to play a part in the cellular processes responsible for these metabolic disorders. Here is the latest research on aging-associated metabolic disorders.
Antibody engineering technologies are constantly advancing to improve the clinical effectiveness of monoclonal and bispecific antibodies. Discover the latest research on Antibody Engineering here.
Mapping bone marrow hematopoiesis by combining single-cell analyses and imaging techniques will facilitate the study of hematopoietic disease and the development of novel therapeutics. This feed includes new research on analysis of the bone marrow hematopoiesis by multiple approaches.
An autophagosome is the formation of double-membrane vesicles that involve numerous proteins and cytoplasmic components. These double-membrane vesicles are then terminated at the lysosome where they are degraded. Discover the latest research on autophagosomes here.
The feed focuses on the role of nuclear export inhibitors and their effect on autophagy and the aging process.
Autophagy is an important cellular process for normal physiology and both elevated and decreased levels of autophagy are associated with disease. Here is the latest research.
Autophagy preserves the health of cells and tissues by replacing outdated and damaged cellular components with fresh ones. In starvation, it provides an internal source of nutrients for energy generation and, thus, survival. A powerful promoter of metabolic homeostasis at both the cellular and whole-animal level, autophagy prevents degenerative diseases. It does have a downside, however--cancer cells exploit it to survive in nutrient-poor tumors.