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Immuno-Oncology

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Immuno-oncology (or cancer immunotherapy) is the artificial stimulation of the immune system to treat cancer, improving on the immune system's natural ability to fight cancer. It exploits the fact that cancer cells often have tumor antigens, molecules on their surface that can be detected by the antibody proteins of the immune system, binding to them. The tumor antigens are often proteins or other macromolecules. Normal antibodies bind to external pathogens, but the modified immunotherapy antibodies bind to the tumor antigens marking and identifying the cancer cells for the immune system to inhibit or kill. Discover the latest research on immuno-oncology here.

Top 20 most recent papers

Safety and feasibility of anti-CD19 CAR T cells with fully human binding domains in patients with B-cell lymphoma

Nature MedicineJanuary 22, 2020

Jennifer N BrudnoJames N Kochenderfer

Intratumoural immunotherapies in oncology

European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)January 22, 2020

Wen XuAlexander M Menzies

Genome-wide CRISPR-Cas9 screening reveals ubiquitous T cell cancer targeting via the monomorphic MHC class I-related protein MR1

Nature ImmunologyJanuary 22, 2020

Michael D CrowtherAndrew K Sewell

mRECIST for HCC: Performance and novel refinements

Journal of HepatologyJanuary 20, 2020

Josep M Llovet, Riccardo Lencioni

Comprehensive Assessment of Immuno-oncology Biomarkers in Adenocarcinoma, Urothelial Carcinoma, and Squamous-cell Carcinoma of the Bladder

European UrologyJanuary 22, 2020

Andrea NecchiJeffrey S Ross

Safety of Timothy Grass Sublingual Immunotherapy Tablet in Children: Pooled Analyses of Clinical Trials

The Journal of Allergy and Clinical Immunology. in PracticeJanuary 19, 2020

Susanne HalkenMichael S Blaiss

Adenosine signalling is prognostic for cancer outcome and has predictive utility for immunotherapeutic response

Clinical Cancer Research : an Official Journal of the American Association for Cancer ResearchJanuary 19, 2020

Ben SiddersKris Sachsenmeier

Tyrosine phosphorylation of ACLY regulates lipid metabolism and oncogenesis in ALK positive Anaplastic Large Cell Lymphoma

bioRxivJanuary 20, 2020

Johnvesly BasappaMegan Lim

Advances in molecular classification and precision oncology in hepatocellular carcinoma

Journal of HepatologyJanuary 20, 2020

Sandra Rebouissou, Jean-Charles Nault

Molecular therapies for HCC: Looking outside the box

Journal of HepatologyJanuary 20, 2020

Sandrine FaivreRichard S Finn

T-cell co-stimulation in combination with targeting FAK drives enhanced anti-tumor immunity

ELifeJanuary 22, 2020

Marta CanelAlan Serrels

Gasdermin E-mediated target cell pyroptosis by CAR T cells triggers cytokine release syndrome

Science ImmunologyJanuary 19, 2020

Yuying LiuBo Huang

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Challenges of combination therapy with immune checkpoint inhibitors for hepatocellular carcinoma

Journal of HepatologyJanuary 20, 2020

Ann-Lii ChengMasatoshi Kudo

Proteomic analysis of malignant and benign endometrium according to obesity and insulin-resistance status using Reverse Phase Protein Array

Translational Research : the Journal of Laboratory and Clinical MedicineJanuary 19, 2020

Olivia RaglanMaria Kyrgiou

Immune profile and immunosurveillance in treatment-naive and neoadjuvantly treated esophageal adenocarcinoma

Cancer Immunology, Immunotherapy : CIIJanuary 22, 2020

Svenja Wagener-RyczekAlexander Quaas

Randomised Clinical Trial: Calorie Restriction Regimen with Tomato Juice Supplementation Ameliorates Oxidative Stress and Preserves a Proper Immune Surveillance Modulating Mitochondrial Bioenergetics of T-Lymphocytes in Obese Children Affected by Non-Alcoholic Fatty Liver Disease (NAFLD)

Journal of Clinical MedicineJanuary 18, 2020

Rossella NegriRaffaele Iorio

Complementary approaches to study NKT cells in cancer

Methods in EnzymologyJanuary 18, 2020

Jay A BerzofskyMasaki Terabe

Prospects of biological and synthetic pharmacotherapies for glioblastoma

Expert Opinion on Biological TherapyJanuary 22, 2020

David B AltshulerMaria G Castro

Different infusion durations for preventing platinum-induced hearing loss in children with cancer

The Cochrane Database of Systematic ReviewsJanuary 22, 2020

Jorrit W van AsElvira C van Dalen

HIV therapeutic vaccines aimed at intensifying combination antiretroviral therapy

Expert Review of VaccinesJanuary 21, 2020

Sonia MorettiBarbara Ensoli

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