Immuno-oncology (or cancer immunotherapy) is the artificial stimulation of the immune system to treat cancer, improving on the immune system's natural ability to fight cancer. It exploits the fact that cancer cells often have tumor antigens, molecules on their surface that can be detected by the antibody proteins of the immune system, binding to them. The tumor antigens are often proteins or other macromolecules. Normal antibodies bind to external pathogens, but the modified immunotherapy antibodies bind to the tumor antigens marking and identifying the cancer cells for the immune system to inhibit or kill. Discover the latest research on immuno-oncology here.

February 28, 2021

Insights Gained from Single-Cell Analysis of Immune Cells in the Tumor Microenvironment.

Annual Review of Immunology
Xianwen RenZemin Zhang
February 28, 2021
Open Access

Immune subtyping for pancreatic cancer with implication in clinical outcomes and improving immunotherapy.

Cancer Cell International
Jingkai LiuQuan Liao
February 28, 2021

Cutaneous Toxicities in Lung Cancer Patients on Immune Checkpoint Inhibitor Therapy.

Clinical Lung Cancer
Monika F KeiserMehmet Altan
February 28, 2021

TGFβ1 neutralization displays therapeutic efficacy through both an immunomodulatory and a non-immune tumor-intrinsic mechanism.

Journal for Immunotherapy of Cancer
Stefania CanèBenoit J Van den Eynde
February 28, 2021

Clinicopathologic and genomic characterization of PD-L1-positive uterine cervical carcinoma.

Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc
Richard S P HuangDouglas I Lin
February 28, 2021

Considering the potential for gene-based therapy in prostate cancer.

Nature Reviews. Urology
Justin R Gregg, Timothy C Thompson
February 28, 2021

The binding epitope of sintilimab on PD-1 revealed by AbMap.

Acta Biochimica Et Biophysica Sinica
Mingliang MaSheng-Ce Tao
February 28, 2021

CRISPR Takes the Front Seat in CART-Cell Development.

BioDrugs : Clinical Immunotherapeutics, Biopharmaceuticals and Gene Therapy
Claudia Manriquez-RomanSaad S Kenderian
February 28, 2021

TNF receptor-associated factor 3 restrains B cell receptor signaling in normal and malignant B cells.

The Journal of Biological Chemistry
Amy L WhillockGail A Bishop
February 28, 2021

Recombinant expression, purification and characterization of human soluble tumor necrosis factor receptor 2.

Protein Expression and Purification
An LiYiming Lu
February 27, 2021

Impact Of Cell-Free Plasma DNA In Metastatic And Non-Metastatic Prostate Cancer.

Current Molecular Medicine
Abdelraouf A AbonarShereen R Mohammed
February 27, 2021
Open Access

Distribution of chimeric antigen receptor-modified T cells against CD19 in B-cell malignancies.

BMC Cancer
Zhitao YingJun Zhu
February 27, 2021
Open Access

Identification of key genes involved in tumor immune cell infiltration and cetuximab resistance in colorectal cancer.

Cancer Cell International
Li LiangTianshu Liu
February 27, 2021
Open Access

mRNA vaccine for cancer immunotherapy.

Molecular Cancer
Lei MiaoLeaf Huang

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