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Immuno-Oncology diagram by StudioMolekuul, Shutterstock
StudioMolekuul, Shutterstock

Immuno-oncology (or cancer immunotherapy) is the artificial stimulation of the immune system to treat cancer, improving on the immune system's natural ability to fight cancer. It exploits the fact that cancer cells often have tumor antigens, molecules on their surface that can be detected by the antibody proteins of the immune system, binding to them. The tumor antigens are often proteins or other macromolecules. Normal antibodies bind to external pathogens, but the modified immunotherapy antibodies bind to the tumor antigens marking and identifying the cancer cells for the immune system to inhibit or kill. Discover the latest research on immuno-oncology here.

Top 20 most recent papers
Nature Medicine

Safety and feasibility of anti-CD19 CAR T cells with fully human binding domains in patients with B-cell lymphoma

Nature MedicineJanuary 22, 2020
Jennifer N BrudnoJames N Kochenderfer
European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)

Intratumoural immunotherapies in oncology

European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)January 22, 2020
Wen XuAlexander M Menzies
Nature Immunology

Genome-wide CRISPR-Cas9 screening reveals ubiquitous T cell cancer targeting via the monomorphic MHC class I-related protein MR1

Nature ImmunologyJanuary 22, 2020
Michael D CrowtherAndrew K Sewell
Journal of Hepatology

mRECIST for HCC: Performance and novel refinements

Journal of HepatologyJanuary 20, 2020
Josep M Llovet, Riccardo Lencioni
European Urology

Comprehensive Assessment of Immuno-oncology Biomarkers in Adenocarcinoma, Urothelial Carcinoma, and Squamous-cell Carcinoma of the Bladder

European UrologyJanuary 22, 2020
Andrea NecchiJeffrey S Ross
The Journal of Allergy and Clinical Immunology. in Practice

Safety of Timothy Grass Sublingual Immunotherapy Tablet in Children: Pooled Analyses of Clinical Trials

The Journal of Allergy and Clinical Immunology. in PracticeJanuary 19, 2020
Susanne HalkenMichael S Blaiss
Clinical Cancer Research : an Official Journal of the American Association for Cancer Research

Adenosine signalling is prognostic for cancer outcome and has predictive utility for immunotherapeutic response

Clinical Cancer Research : an Official Journal of the American Association for Cancer ResearchJanuary 19, 2020
Ben SiddersKris Sachsenmeier

Tyrosine phosphorylation of ACLY regulates lipid metabolism and oncogenesis in ALK positive Anaplastic Large Cell Lymphoma

bioRxivJanuary 20, 2020
Johnvesly BasappaMegan Lim
Journal of Hepatology

Advances in molecular classification and precision oncology in hepatocellular carcinoma

Journal of HepatologyJanuary 20, 2020
Sandra Rebouissou, Jean-Charles Nault
Journal of Hepatology

Molecular therapies for HCC: Looking outside the box

Journal of HepatologyJanuary 20, 2020
Sandrine FaivreRichard S Finn

T-cell co-stimulation in combination with targeting FAK drives enhanced anti-tumor immunity

ELifeJanuary 22, 2020
Marta CanelAlan Serrels
Science Immunology

Gasdermin E-mediated target cell pyroptosis by CAR T cells triggers cytokine release syndrome

Science ImmunologyJanuary 19, 2020
Yuying LiuBo Huang
Journal of Hepatology

Challenges of combination therapy with immune checkpoint inhibitors for hepatocellular carcinoma

Journal of HepatologyJanuary 20, 2020
Ann-Lii ChengMasatoshi Kudo
Translational Research : the Journal of Laboratory and Clinical Medicine

Proteomic analysis of malignant and benign endometrium according to obesity and insulin-resistance status using Reverse Phase Protein Array

Translational Research : the Journal of Laboratory and Clinical MedicineJanuary 19, 2020
Olivia RaglanMaria Kyrgiou
Cancer Immunology, Immunotherapy : CII

Immune profile and immunosurveillance in treatment-naive and neoadjuvantly treated esophageal adenocarcinoma

Cancer Immunology, Immunotherapy : CIIJanuary 22, 2020
Svenja Wagener-RyczekAlexander Quaas
Journal of Clinical Medicine

Randomised Clinical Trial: Calorie Restriction Regimen with Tomato Juice Supplementation Ameliorates Oxidative Stress and Preserves a Proper Immune Surveillance Modulating Mitochondrial Bioenergetics of T-Lymphocytes in Obese Children Affected by Non-Alcoholic Fatty Liver Disease (NAFLD)

Journal of Clinical MedicineJanuary 18, 2020
Rossella NegriRaffaele Iorio
Methods in Enzymology

Complementary approaches to study NKT cells in cancer

Methods in EnzymologyJanuary 18, 2020
Jay A BerzofskyMasaki Terabe
Expert Opinion on Biological Therapy

Prospects of biological and synthetic pharmacotherapies for glioblastoma

Expert Opinion on Biological TherapyJanuary 22, 2020
David B AltshulerMaria G Castro
The Cochrane Database of Systematic Reviews

Different infusion durations for preventing platinum-induced hearing loss in children with cancer

The Cochrane Database of Systematic ReviewsJanuary 22, 2020
Jorrit W van AsElvira C van Dalen
Expert Review of Vaccines

HIV therapeutic vaccines aimed at intensifying combination antiretroviral therapy

Expert Review of VaccinesJanuary 21, 2020
Sonia MorettiBarbara Ensoli

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