Immunogenetics of Systemic Lupus Erythematosus

SLE is an autoimmune disease whose cause remains unclear and for which only symptomatic treatments currently exist. Linking the genetic and epigenetic assocations to molecular pathways and cellular phenotype is required to understand this disease and advance therapeutics. Find the latest research on the immunnogenetics of SLE here.

June 7, 2020
Open Access

The regulation and pharmacological modulation of immune complex induced type III IFN production by plasmacytoid dendritic cells

Arthritis Research & Therapy
Karin HjortonLars Rönnblom
June 23, 2020

Alterations in corneal biomechanics underlie early stages of autoimmune-mediated dry eye disease

Journal of Autoimmunity
Yael EfraimSarah M Knox
May 8, 2020
Open Access

Impact of COVID-19 pandemic on SLE: beyond the risk of infection

Lupus Science & Medicine
Alice HorisbergerDenis Comte
April 12, 2020
Open Access

Identification of 38 novel loci for systemic lupus erythematosus and genetic heterogeneity that may underly population disparities in this disease

BioRxiv : the Preprint Server for Biology
Y.-F. WangWanling Yang
March 20, 2020
Open Access

Protein-based Immunome Wide Association Studies (PIWAS) for the discovery of significant disease-associated antigens

BioRxiv : the Preprint Server for Biology
Winston Andrew HaynesJohn C Shon
December 27, 2019

Staphylococcus aureus Colonization Is Increased on Lupus Skin Lesions and Is Promoted by IFN-Mediated Barrier Disruption

The Journal of Investigative Dermatology
Sirisha SirobhushanamJ Michelle Kahlenberg
April 5, 2020

An update on genetic susceptibility in lupus nephritis

Clinical Immunology : the Official Journal of the Clinical Immunology Society
Kangkang SongXiangmei Chen
July 2, 2020

Rethinking the Pathogenesis of Cutaneous Lupus

The Journal of Investigative Dermatology
J Michelle Kahlenberg
April 8, 2020
Open Access

Relationship between miR-155 and miR-146a polymorphisms and susceptibility to multiple sclerosis in an Egyptian cohort

Biomedical Reports
Marwa Ahmed AliSylvana Nady Gaber
January 20, 2020
Open Access

Genome-wide discovery of lupus genetic risk variant allelic regulatory activity

BioRxiv : the Preprint Server for Biology
Xiaoming LuLeah C Kottyan
May 24, 2020

Epigenetic Methods and Twin Studies

Advances in Experimental Medicine and Biology
Angela Ceribelli, Carlo Selmi
March 11, 2020
Open Access

New Horizons in the Genetic Etiology of Systemic Lupus Erythematosus and Lupus-Like Disease: Monogenic Lupus and Beyond

Journal of Clinical Medicine
Erkan DemirkayaIvona Aksentijevich
January 31, 2020
Open Access

TLR7 Agonism Accelerates Disease and Causes a Fatal Myeloproliferative Disorder in NZM 2410 Lupus Mice

Frontiers in Immunology
Jena R WirthMelissa A Cunningham
January 1, 2020
Open Access

A potential association between IL-3 and type I and III interferons in systemic lupus erythematosus

Clinical & Translational Immunology
Shereen OonNicholas J Wilson

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