Immunoglobulin Somatic Hypermutation

DNA editing by the cytidine deaminase aid mediates immunoglobulin somatic hypermutation and class switch recombination, providing the antibody response with the flexibility and diversity to defend against an almost limitless array of varied and rapidly adapting pathogenic challenges. Discover the latest research on immunoglobulin somatic hypermutation here.

January 1, 2021
Case Report

Identical Twins with a Mutation in the STK4 Gene Showing Clinical Manifestations of the Mutation at Different Ages: A Case Report

Iranian Journal of Immunology : IJI
Farhad AbolnezhadianFatemeh Ahmadpour
January 9, 2021
Open Access

Immune landscape and prognostic immune-related genes in KRAS-mutant colorectal cancer patients

Journal of Translational Medicine
Jungang LiuWeizhong Tang
January 7, 2021

Tectocerebellar dysraphia and occipital encephalocele associated with trisomy X: case report and review of the literature

Child's Nervous System : ChNS : Official Journal of the International Society for Pediatric Neurosurgery
Lissa C GoulartOsvaldo Vilela-Filho
January 6, 2021
Open Access

Biomarkers of response to ibrutinib plus nivolumab in relapsed diffuse large B-cell lymphoma, follicular lymphoma, or Richter's transformation

Translational Oncology
Brendan P HodkinsonSriram Balasubramanian
January 20, 2021
Preprint
Open Access

Extreme C-to-A Hypermutation at a Site of Cytosine-N4 Methylation

BioRxiv : the Preprint Server for Biology
Joshua L. Cherry
January 20, 2021
Preprint
Open Access

Novel deep learning algorithm predicts the status of molecular pathways and key mutations in colorectal cancer from routine histology images

MedRxiv : the Preprint Server for Health Sciences
M. BilalNasir M. Rajpoot
December 10, 2020

Post-Treatment Hypermutation in a Recurrent Diffuse Glioma with H3.3 p.G34 Mutation

Neuropathology and Applied Neurobiology
Matthew D WoodKellie J Nazemi
December 21, 2020
Open Access

Molecular profiling of long-term responders to immune checkpoint inhibitors in advanced non-small cell lung cancer

Molecular Oncology
Joan FrigolaRamon Amat
January 7, 2021

An Unusual Pattern of Premature Cervical Spine Degeneration in STAT3-LOF

Journal of Clinical Immunology
Amelia L MitchellDima A Hammoud
December 17, 2020
Comment / Editorial

Dissecting the Functional Significance of DNA Polymerase Mutations in Cancer

Cancer Research
Amy J Wisdom, David G Kirsch
January 11, 2021

Germline APOBEC3B deletion increases somatic hypermutation in Asian breast cancer that is associated with Her2 subtype, PIK3CA mutations, and immune activation

International Journal of Cancer. Journal International Du Cancer
Jia-Wern PanSoo-Hwang Teo
January 8, 2021
Open Access

Analysis of nonleukemic cellular subcompartments reconstructs clonal evolution of acute myeloid leukemia and identifies therapy-resistant preleukemic clones

International Journal of Cancer. Journal International Du Cancer
Borhan R SaeedChristoph Lutz
January 9, 2021

ARID1A mutation may define an immunologically active subgroup in patients with microsatellite-stable colorectal cancer

Clinical Cancer Research : an Official Journal of the American Association for Cancer Research
Amir Mehrvarz SarshekehScott Kopetz

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