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Immunological Genome Project

Immunological Genome Project  diagram by undefined

The Immunological Genome Project (ImmGen) aims to build a gene expression database for murine immune cells. This will allow for the computational reconstruction of genetic regulatory networks across the immune system. Follow the latest research from ImmGen researchers here.

Top 20 most recent papers
Nature

Distinct fibroblast subsets drive inflammation and damage in arthritis

NatureMay 31, 2019
Adam Paul CroftChristopher Dominic Buckley
142
5
3
208
1
Cell

Single-Cell Analysis of Crohn's Disease Lesions Identifies a Pathogenic Cellular Module Associated with Resistance to Anti-TNF Therapy

CellAugust 26, 2019
Jérôme C MartinEphraim Kenigsberg
191
5
1
153
Nature Medicine

Single-cell immune landscape of human atherosclerotic plaques

Nature MedicineOctober 7, 2019
Dawn M FernandezChiara Giannarelli
301
3
8
72
1
Cell

Dietary Intake Regulates the Circulating Inflammatory Monocyte Pool

CellAugust 22, 2019
Stefan JordanMiriam Merad
684
20
6
172
1
1
1
bioRxiv

Serum Amyloid A Proteins Induce Pathogenic TH17 Cells and Promote Inflammatory Disease

bioRxivJune 25, 2019
June-Yong LeeDan R. Littman
15
Nature Methods

Fast, sensitive and accurate integration of single-cell data with Harmony

Nature MethodsNovember 20, 2019
Ilya KorsunskySoumya Raychaudhuri
173
Nature Communications

The Firre locus produces a trans-acting RNA molecule that functions in hematopoiesis

Nature CommunicationsNovember 13, 2019
Jordan P. LewandowskiJohn L. Rinn
47
1
Nature Immunology

Denisovan, modern human and mouse TNFAIP3 alleles tune A20 phosphorylation and immunity

Nature ImmunologySeptember 20, 2019
Nathan W. ZammitShane T. Grey
35
20
22
1
bioRxiv

DNA Break-Induced Epigenetic Drift as a Cause of Mammalian Aging

bioRxivOctober 21, 2019
Motoshi HayanoDavid Andrew Sinclair
151
Nature Immunology

Fibroblastic reticular cells enhance T cell metabolism and survival via epigenetic remodeling

Nature ImmunologyOctober 23, 2019
Flavian D BrownShannon J Turley
44
35
1
Nature Immunology

Publisher Correction: The immune cell landscape in kidneys of patients with lupus nephritis

Nature ImmunologyAugust 15, 2019
Arnon AraziAccelerating Medicines Partnership in SLE network
1
Cancer Discovery

Antitumor T-cell Homeostatic Activation Is Uncoupled from Homeostatic Inhibition by Checkpoint Blockade

Cancer DiscoveryAugust 2, 2019
Netonia MarshallJoshua D Brody
20
17
19
bioRxiv

Complex Autoinflammatory Syndrome Unveils Fundamental Principles of JAK1 Transcriptional and Biochemical Function

bioRxivOctober 17, 2019
Conor N GruberDusan Bogunovic
61
2
Methods in Molecular Biology

Multiplexed Immunohistochemical Consecutive Staining on Single Slide (MICSSS): Multiplexed Chromogenic IHC Assay for High-Dimensional Tissue Analysis

Methods in Molecular BiologySeptember 11, 2019
Guray AkturkSacha Gnjatic
7
5
Immunity

T-bet Transcription Factor Promotes Antibody-Secreting Cell Differentiation by Limiting the Inflammatory Effects of IFN-γ on B Cells

ImmunityMay 12, 2019
Sara L. StoneFrances E. Lund
40
1
65
The Journal of Experimental Medicine

Developmental and cellular age direct conversion of CD4+ T cells into RORγ+ or Helios+ colon Treg cells

The Journal of Experimental MedicineNovember 4, 2019
Alvin PratamaChristophe O Benoist
Immunity

A Stromal Niche Defined by Expression of the Transcription Factor WT1 Mediates Programming and Homeostasis of Cavity-Resident Macrophages

ImmunityJune 25, 2019
Matthew B BuechlerShannon J Turley
61
41
1
JCI Insight

PD-1hiCXCR5- T peripheral helper cells promote B cell responses in lupus via MAF and IL-21

JCI InsightSeptember 20, 2019
Alexandra V BocharnikovAccelerating Medicines Partnership (AMP) RA/SLE Network
6
10
Cancer Discovery

Single-cell RNA sequencing reveals stromal evolution into LRRC15+ myofibroblasts as a determinant of patient response to cancer immunotherapy

Cancer DiscoveryNovember 7, 2019
Claudia X DominguezShannon J Turley
36
1
The Journal of Clinical Investigation

PAHSAs attenuate immune responses and promote β cell survival in autoimmune diabetic mice

The Journal of Clinical InvestigationAugust 5, 2019
ISMAIL SYEDBarbara B Kahn
16
3
4

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