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Immunological Genome Project

Immunological Genome Project  diagram by Alpha Tauri 3D Graphics, Wikimedia
Alpha Tauri 3D Graphics, Wikimedia

The Immunological Genome Project (ImmGen) aims to build a gene expression database for murine immune cells. This will allow for the computational reconstruction of genetic regulatory networks across the immune system. Follow the latest research from ImmGen researchers here.

Top 20 most recent papers
The Journal of Biological Chemistry

Relative stabilities of wild-type and mutant glial fibrillary acidic protein in patients with Alexander disease

The Journal of Biological ChemistrySeptember 6, 2019
Michael R HeavenMichael B Brenner
Nature Methods

Fast, sensitive and accurate integration of single-cell data with Harmony

Nature MethodsNovember 20, 2019
Ilya KorsunskySoumya Raychaudhuri
Proceedings of the National Academy of Sciences of the United States of America

Neutrophils promote VLA-4-dependent B cell antigen presentation and accumulation within the meninges during neuroinflammation

Proceedings of the National Academy of Sciences of the United States of AmericaNovember 9, 2019
Chelsea R Parker HarpGregory F Wu
Nature Medicine

Single-cell immune landscape of human atherosclerotic plaques

Nature MedicineOctober 9, 2019
Dawn M FernandezChiara Giannarelli
Nature Genetics

Allele-specific expression changes dynamically during T cell activation in HLA and other autoimmune loci

Nature GeneticsFebruary 19, 2020
Maria Gutierrez-ArcelusSoumya Raychaudhuri
Proceedings of the National Academy of Sciences of the United States of America

T cell receptor specificity drives accumulation of a reparative population of regulatory T cells within acutely injured skeletal muscle

Proceedings of the National Academy of Sciences of the United States of AmericaDecember 12, 2019
Jun ChoDiane Mathis
Nature Immunology

Denisovan, modern human and mouse TNFAIP3 alleles tune A20 phosphorylation and immunity

Nature ImmunologySeptember 20, 2019
Nathan W ZammitShane T Grey

Antitumour T cells stand the test of time

NatureDecember 18, 2019
Miguel Reina-Campos, Ananda W Goldrath

Universal Principled Review: A Community-Driven Method to Improve Peer Review

CellDecember 14, 2019
Matthew KrummelFuture Immunology Consortium

Reinvigorating NIH Grant Peer Review

ImmunityJanuary 16, 2020
Shane CrottyOnce-a-Year Pledge Supporters
Immunological Reviews

Visceral adipose tissue Tregs and the cells that nurture them

Immunological ReviewsMarch 13, 2020
Chaoran LiDiane Mathis

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Human Vascular Endothelial Cell Atlas: Young & Old

Examining the genomics, transcriptomics, proteomics and metabolomics of the human vascular endothelial cells at the single cell level will help build a single cell atlas of human vascular endothelium, which would give a unique ID card for each cell type, a three-dimensional map of how cell types work together to form tissues and insights into how changes in the map underlie health and disease of the vascular endothelium from young to old age. Disocver the latest research on the single cell atlas of human vascular endothelial cell atlas here.

STING Receptor Agonists

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Myocardial Stunning

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LRRK2 and Microtubules

Mutations in the LRRK2 gene are risk-factors for developing Parkinson’s disease (PD). LRRK2 mutations in PD have been shown to enhance its association with microtubules. Here is the latest research.

Chronic Fatigue Syndrome

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Asperger Syndrome

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Mechanisms of Axon Degeneration

The mechanism of axonal degeneration is still poorly understood, but studies in animal models have suggested some cellular and molecular mechanisms responsible. The degeneration of axons in the CNS has been found to be characteristic of many neurodegenerative diseases. Discover the latest research on the mechanisms of axon degeneration here.


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