Innate Immunity and Neurodegeneration

The innate immune response is an important regulator of the downstream immune response, and it is becoming increasingly evident that immune dysfunction has impacts on the pathogenesis of multiple disease states, including neurodegeneration. Additionally, mutations in several genes involved in the innate immune response have been associated with neurodegeneration. Discover the latest research on innate immunity and neurodegeneration here.

August 3, 2020

Neuroinflammation and histone H3 citrullination are increased in X-linked Dystonia Parkinsonism post-mortem prefrontal cortex

Neurobiology of Disease
Tiziana PetrozzielloGhazaleh Sadri-Vakili
July 23, 2020

Peripheral inflammation exacerbates α-synuclein toxicity and neuropathology in Parkinson's models

Neuropathology and Applied Neurobiology
Pietro La VitolaGianluigi Forloni
July 18, 2020
Review
Open Access

Molecular and cellular mechanisms underlying the pathogenesis of Alzheimer's disease

Molecular Neurodegeneration
Tiantian GuoYingjun Zhao
July 18, 2020
Review
Open Access

Inflammation in Parkinson's Disease: Mechanisms and Therapeutic Implications

Cells
Marta PajaresAntonio Cuadrado
July 29, 2020
Review
Open Access

SAMHD1 acts at stalled replication forks to prevent interferon induction

Comptes rendus biologies
F CoquelP Pasero
July 30, 2020

Aging and sex: Impact on microglia phagocytosis

Aging Cell
Natalia Yanguas-CasásLuis Miguel Garcia-Segura
July 19, 2020
Open Access

Neuroinflammation is associated with infiltration of T cells in Lewy body disease and α-synuclein transgenic models

Journal of Neuroinflammation
Michiyo IbaEliezer Masliah
July 23, 2020
Review
Open Access

COVID-19 and olfactory dysfunction: A possible associative approach towards neurodegenerative diseases

Journal of Cellular Physiology
Iyer MahalaxmiVellingiri Balachandar
July 28, 2020
Preprint
Open Access

Systemic inflammation causes microglial dysfunction with a mixed AD-like pathology.

BioRxiv : the Preprint Server for Biology
P. BathiniLavinia Alberi
July 29, 2020
Open Access

Knockout of reactive astrocyte activating factors slows disease progression in an ALS mouse model

Nature Communications
Kevin A GuttenplanBen A Barres
July 28, 2020
Review
Open Access

Vesicular Transport of Encapsulated microRNA between Glial and Neuronal Cells

International Journal of Molecular Sciences
Walter J Lukiw, Aileen I Pogue
July 27, 2020
Open Access

Genetic factors related to the immune system in subjects at risk of developing Alzheimer's disease

Journal of Integrative Neuroscience
Michał PrendeckiJolanta Dorszewska
July 27, 2020
Open Access

Trem2 deficiency differentially affects phenotype and transcriptome of human APOE3 and APOE4 mice

Molecular Neurodegeneration
Nicholas F FitzRadosveta Koldamova
July 30, 2020

Immunomodulatory effect and clinical outcome in Parkinson's disease patients on levodopa-pramipexole combo therapy: A two-year prospective study

Journal of Neuroimmunology
Raquel Espinosa-CárdenasLaura Adalid-Peralta
July 29, 2020
Open Access

CD36-mediated uptake of myelin debris by macrophages and microglia reduces neuroinflammation

Journal of Neuroinflammation
Elien GrajchenJeroen F J Bogie
August 1, 2020
Preprint

Multiplexed fractionated proteomics reveals synaptic factors associated with cognitive resilience in Alzheimer's Disease

BioRxiv : the Preprint Server for Biology
Becky Catherine CarlyleS. E. Arnold

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