Innate Immunity: Neurodegeneration

The innate immune system is a first line of defense against infection. Pathological states can occur if there is over activation of the innate immune system, particularly in the brain. The excessive activation of these cells can lead to inflammation and neurodegenerative diseases. Here is the latest research on innate immunity and neurodegeneration.

November 29, 2021
Open Access

Dysregulated phosphoinositide 3-kinase signaling in microglia: shaping chronic neuroinflammation.

Journal of Neuroinflammation
Erskine ChuBridgette D Semple
November 28, 2021
Open Access

TLR-Mediated Signal Transduction and Neurodegenerative Disorders.

Brain Sciences
Shashank Vishwanath AdhikarlaSaurabh Kumar Jha
November 4, 2021
Open Access

Repeats Mimic Immunostimulatory Viral Features Across a Vast Evolutionary Landscape

BioRxiv : the Preprint Server for Biology
P. SulcBenjamin D. Greenbaum
November 2, 2021
Comment / Editorial

Imaging immune responses in neuroinflammatory diseases.

Clinical and Experimental Immunology
Sandra AmorDavid Owen
October 29, 2021

Genomics of Alzheimer's disease implicates the innate and adaptive immune systems.

Cellular and Molecular Life Sciences : CMLS
Yihan LiBen J Gu
October 26, 2021
Open Access

The Assessment of Selected miRNA Profile in Familial Mediterranean Fever.

BioMed Research International
Cigdem Yuce KahramanAdil Mardinoglu
October 24, 2021
Open Access

Glial PAMPering and DAMPening of Adult Hippocampal Neurogenesis.

Brain Sciences
Luke Parkitny, Mirjana Maletic-Savatic
October 5, 2021

Phospholipase Cγ2 regulates endocannabinoid and eicosanoid networks in innate immune cells.

Proceedings of the National Academy of Sciences of the United States of America
Hui JingBenjamin F Cravatt
October 4, 2021
Open Access

Innate Immune System Activation and Neuroinflammation in Down Syndrome and Neurodegeneration: Therapeutic Targets or Partners?

Frontiers in Aging Neuroscience
Md Mahiuddin AhmedHuntington Potter
September 30, 2021
Open Access

Transcriptome analyses reveal tau isoform-driven changes in transposable element and gene expression.

PloS One
Jennifer GrundmanRobert A Rissman
September 17, 2021

Toll-like receptor 4 deficiency facilitates α-synuclein propagation and neurodegeneration in a mouse model of prodromal Parkinson's disease.

Parkinsonism & Related Disorders
Serena VeneziaNadia Stefanova
August 27, 2021
Open Access

Immunohistochemical Study of ASC Expression and Distribution in the Hippocampus of an Aged Murine Model of Alzheimer's Disease.

International Journal of Molecular Sciences
Diana ReimersEulalia Bazan
August 27, 2021
Open Access

Mitochondria-Induced Immune Response as a Trigger for Neurodegeneration: A Pathogen from Within.

International Journal of Molecular Sciences
Marta Luna-SánchezAlbert Quintana
August 27, 2021
Open Access

Triggering Innate Immune Receptors as New Therapies in Alzheimer's Disease and Multiple Sclerosis.

Pierre-Alexandre PiecSerge Rivest
August 25, 2021

Histamine in the Crosstalk Between Innate Immune Cells and Neurons: Relevance for Brain Homeostasis and Disease.

Current Topics in Behavioral Neurosciences
Liliana Bernardino
August 21, 2021

Retinal Ganglion Cell Axon Regeneration Requires Complement and Myeloid Cell Activity within the Optic Nerve.

The Journal of Neuroscience : the Official Journal of the Society for Neuroscience
Sheri L PetersonLarry I Benowitz
August 20, 2021

Advances in microglia cellular models: focus on extracellular vesicle production.

Biochemical Society Transactions
Lorenzo CeccarelliClaudia Martini

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