Innate Immunity & Neurodegeneration

The innate immune response is an important regulator of the downstream immune response, and it is becoming increasingly evident that immune dysfunction has impacts on the pathogenesis of multiple disease states, including neurodegeneration. Additionally, mutations in several genes involved in the innate immune response have been associated with neurodegeneration. Discover the latest research on innate immunity and neurodegeneration here.

November 11, 2020
Open Access

Diabetic phenotype in mouse and humans reduces the number of microglia around β-amyloid plaques

Molecular Neurodegeneration
Teemu NatunenMikko Hiltunen
November 18, 2020
Review
Open Access

Can the coronavirus infection penetrates the brain resulting in sudden anosmia followed by severe neurological disorders?

ENeurologicalSci
Mai M AnwarNadia A Eltablawy
November 20, 2020

2,5-hexanedione induces NLRP3 inflammasome activation and neurotoxicity through NADPH oxidase-dependent pathway

Free Radical Biology & Medicine
Ruixue HuangQingshan Wang
November 25, 2020
Review
Open Access

Impact of pediatric traumatic brain injury on hippocampal neurogenesis

Neural Regeneration Research
Mariam RizkZhi Zhang
November 17, 2020
Review
Open Access

Microglial Immunometabolism in Alzheimer's Disease

Frontiers in Cellular Neuroscience
Daniel C Shippy, Tyler K Ulland
November 19, 2020
Open Access

Tau Pathology Drives Dementia Risk-Associated Gene Networks toward Chronic Inflammatory States and Immunosuppression

Cell Reports
Jessica E RexachDaniel H Geschwind
November 12, 2020
Open Access

Repeat RNA expansion disorders of the nervous system: post-transcriptional mechanisms and therapeutic strategies

Critical Reviews in Biochemistry and Molecular Biology
Joshua L SchwartzGene W Yeo
November 24, 2020
Open Access

Diesel exhaust impairs TREM2 to dysregulate neuroinflammation

Journal of Neuroinflammation
Hendrik J GreveMichelle L Block
November 15, 2020
Preprint
Open Access

Upregulated functionality of mitochondria-associated ER membranes in a mouse model of traumatic brain injury

BioRxiv : the Preprint Server for Biology
R. R. AgrawalEstela Area-Gomez
November 17, 2020
Review
Open Access

Gut Microbiota Approach-A New Strategy to Treat Parkinson's Disease

Frontiers in Cellular and Infection Microbiology
Jing LiuLei Shao
November 19, 2020

Manganese-induced neurotoxicity in cerebellar granule neurons due to perturbation of cell network pathways with potential implications for neurodegenerative disorders

Metallomics : Integrated Biometal Science
Raúl Bonne HernándezCristina Suñol
November 17, 2020
Open Access

Gas6 Inhibits Toll-Like Receptor-Mediated Inflammatory Pathways in Mouse Microglia via Axl and Mer

Frontiers in Cellular Neuroscience
Shannon E GilchristSassan Hafizi
November 13, 2020
Review
Open Access

Degradation and Transmission of Tau by Autophagic-Endolysosomal Networks and Potential Therapeutic Targets for Tauopathy

Frontiers in Molecular Neuroscience
Shanya Jiang, Kiran Bhaskar
November 17, 2020

Mitochondrial Targeting of Probes and Therapeutics to the Powerhouse of the Cell

Bioconjugate Chemistry
Cindy MaShana O Kelley

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