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Interferon Signalling

Interferon Signalling diagram by Nevit Dilmen, Wikimedia
Nevit Dilmen, Wikimedia

Via interaction with their specific receptors, interferons (IFNs) activate signal transducer and activator of transcription (STAT) complexes. STAT activation initiates the classical Janus kinase-STAT (JAK-STAT) signaling pathway. In this pathway, JAKs associate with IFN receptors and, following receptor engagement with IFN, phosphorylate both STAT1 and STAT2. As a result, an IFN-stimulated gene factor 3 (ISGF3) complex forms—this contains STAT1, STAT2 and a third transcription factor called IRF9—and moves into the cell nucleus. Inside the nucleus, the ISGF3 complex binds to specific nucleotide sequences called IFN-stimulated response elements (ISREs) in the promoters of certain genes, known as IFN stimulated genes. Discover the latest research on interferon signalling here.

Top 20 most recent papers
Nature Microbiology

Select autophagy genes maintain quiescence of tissue-resident macrophages and increase susceptibility to Listeria monocytogenes

Nature MicrobiologyJanuary 22, 2020
Ya-Ting WangHerbert W Virgin
European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)

Intratumoural immunotherapies in oncology

European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)January 22, 2020
Wen XuAlexander M Menzies
Journal for Immunotherapy of Cancer

Enhanced efficacy and limited systemic cytokine exposure with membrane-anchored interleukin-12 T-cell therapy in murine tumor models

Journal for Immunotherapy of CancerJanuary 22, 2020
Ling ZhangChristian S Hinrichs
Trends in Immunology

Key Roles of MiT Transcription Factors in Innate Immunity and Inflammation

Trends in ImmunologyJanuary 22, 2020
Javier E Irazoqui
The British Journal of Dermatology

Association of IRF4 SNP rs12203592 with melanoma-specific survival

The British Journal of DermatologyJanuary 21, 2020
S V WardGEM Study Group
The Lancet. Respiratory Medicine

Concise whole blood transcriptional signatures for incipient tuberculosis: a systematic review and patient-level pooled meta-analysis

The Lancet. Respiratory MedicineJanuary 21, 2020
Rishi K GuptaMahdad Noursadeghi
Angewandte Chemie

Integrating Allyl Electrophiles into Nickel-Catalyzed Conjunctive Cross-Coupling

Angewandte ChemieJanuary 21, 2020
Van TranKeary Mark Engle
PLoS Pathogens

G protein α subunit suppresses sporangium formation through a serine/threonine protein kinase in Phytophthora sojae

PLoS PathogensJanuary 22, 2020
Min QiuYuanchao Wang
Osteoarthritis and Cartilage

Skeletal deterioration in COL2A1-related spondyloepiphyseal dysplasia occurs prior to osteoarthritis

Osteoarthritis and CartilageJanuary 21, 2020
Tim RolvienRalf Oheim
PloS One

Two common disease-associated TYK2 variants impact exon splicing and TYK2 dosage

PloS OneJanuary 22, 2020
Zhi LiSandra Pellegrini

Lung type II alveolar epithelial cells collaborate with CCR2+ inflammatory monocytes in host defense against an acute vaccinia infection in the lungs

bioRxivJanuary 21, 2020
Ning YangLiang Deng
Microbes and Infection

Pneumococcal Conjugate Vaccine Modulates Macrophage-mediated Innate Immunity in Pneumonia Caused by Streptococcus pneumoniae Following Influenza

Microbes and InfectionJanuary 21, 2020
Kazuyuki MimuraKazuhiro Tateda
Arthritis & Rheumatology

Methionine commits cells to differentiate into plasmablasts through epigenetic regulation of BTB and CNC homolog 2 by the methyltransferase enhancer of zeste homolog 2

Arthritis & RheumatologyJanuary 22, 2020
Mingzeng ZhangYoshiya Tanaka
The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences

Aging Blunts Sympathetic Neuron Regulation of Motoneuron Synaptic Vesicle Release Mediated by β1- and α2B-Adrenergic Receptors in Geriatric Mice

The Journals of Gerontology. Series A, Biological Sciences and Medical SciencesJanuary 21, 2020
Zhong-Min WangOsvaldo Delbono
Clinical Oral Investigations

Effect of gamma-ray sterilization on phase transformation behavior and fatigue resistance of contemporary nickel-titanium instruments

Clinical Oral InvestigationsJanuary 21, 2020
Ana AriasOve A Peters
Molecular Immunology

EZH2 inhibitors restore epigenetically silenced CD58 expression in B-cell lymphomas

Molecular ImmunologyJanuary 22, 2020
Yasuyuki OtsukaAkifumi Takaori-Kondo

A stable core of GCPs 4, 5 and 6 promotes the assembly of γ-tubulin ring complexes

bioRxivJanuary 21, 2020
Andreas MerdesLaurent Emorine
Journal of Periodontal Research

Inflammasomes and their regulation in periodontal disease: A review

Journal of Periodontal ResearchJanuary 22, 2020
Kübra AralPaul R Cooper
Journal of Gastroenterology

Activation of interferon regulatory factor 7 in plasmacytoid dendritic cells promotes experimental autoimmune pancreatitis

Journal of GastroenterologyJanuary 22, 2020
Kosuke MinagaMasatoshi Kudo
Comparative Biochemistry and Physiology. Toxicology & Pharmacology : CBP

Oxidative stress, ion concentration change and immune response in gills of common carp (Cyprinus carpio) under long-term exposure to bisphenol A

Comparative Biochemistry and Physiology. Toxicology & Pharmacology : CBPJanuary 21, 2020
Zhengyan GuGuojun Yin

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