Interferon Signalling

Via interaction with their specific receptors, interferons (IFNs) activate signal transducer and activator of transcription (STAT) complexes. STAT activation initiates the classical Janus kinase-STAT (JAK-STAT) signaling pathway. In this pathway, JAKs associate with IFN receptors and, following receptor engagement with IFN, phosphorylate both STAT1 and STAT2. As a result, an IFN-stimulated gene factor 3 (ISGF3) complex forms—this contains STAT1, STAT2 and a third transcription factor called IRF9—and moves into the cell nucleus. Inside the nucleus, the ISGF3 complex binds to specific nucleotide sequences called IFN-stimulated response elements (ISREs) in the promoters of certain genes, known as IFN stimulated genes. Discover the latest research on interferon signalling here.

August 3, 2020

Novel concepts in plasmacytoid dendritic cell (pDC) development and differentiation

Molecular Immunology
Patrick Fernandes Rodrigues, Roxane Tussiwand
August 3, 2020

Boron analysis and imaging of cells with 2-hr BPA exposure by using micro-proton particle-induced gamma-ray emission (PIGE)

Applied Radiation and Isotopes : Including Data, Instrumentation and Methods for Use in Agriculture, Industry and Medicine
Kei NakaiHideyuki Sakurai
August 2, 2020

Fermi-crossing Type-II Dirac fermions and topological surface states in NiTe2

Scientific Reports
Saumya MukherjeeCephise Cacho
August 2, 2020

Climate-associated drivers of plasma cytokines and contaminant concentrations in Beaufort Sea polar bears (Ursus maritimus)

The Science of the Total Environment
Jennifer BourqueMelissa A McKinney
August 2, 2020

Characteristics of Acute Stroke Patients Readmitted to Inpatient Rehabilitation Facilities - a Cohort Study

PM & R : the Journal of Injury, Function, and Rehabilitation
Nneka IfejikaJames C Grotta
August 3, 2020

Phosphatidylinositol-3-kinase-Akt pathway in negative-stranded RNA virus infection: a minireview

Archives of Virology
Javier BlancoIsabel Muñoz-Barroso
August 2, 2020

Ameliorative role of curcumin on copper oxide nanoparticles-mediated renal toxicity in rats: An investigation of molecular mechanisms

Journal of Biochemical and Molecular Toxicology
Shereen A ElkhateebOmaima I A Hamid
August 2, 2020

Human CLEC9A antibodies deliver NY-ESO-1 antigen to CD141+ dendritic cells to activate naïve and memory NY-ESO-1-specific CD8+ T cells

Journal for Immunotherapy of Cancer
Kelly-Anne MastermanKristen J Radford
August 2, 2020

ACE2 is not induced by interferon

Nature Reviews. Immunology
Miriam Saffern
August 2, 2020

NKp30 - a prospective target for new cancer immunotherapy strategies

British Journal of Pharmacology
Pedro F PinheiroM Matilde Marques

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