Interferon Signalling

Via interaction with their specific receptors, interferons (IFNs) activate signal transducer and activator of transcription (STAT) complexes. STAT activation initiates the classical Janus kinase-STAT (JAK-STAT) signaling pathway. In this pathway, JAKs associate with IFN receptors and, following receptor engagement with IFN, phosphorylate both STAT1 and STAT2. As a result, an IFN-stimulated gene factor 3 (ISGF3) complex forms—this contains STAT1, STAT2 and a third transcription factor called IRF9—and moves into the cell nucleus. Inside the nucleus, the ISGF3 complex binds to specific nucleotide sequences called IFN-stimulated response elements (ISREs) in the promoters of certain genes, known as IFN stimulated genes. Discover the latest research on interferon signalling here.

January 19, 2021

Cytokine Profiles Before and After Immune Modulation in Hospitalized Patients with COVID-19

Journal of Clinical Immunology
Veronica AzmyChristina C Price
January 19, 2021
Open Access

Angiotensin-Converting Enzyme Inhibitor, Captopril, Improves Scar Healing in Hypertensive Rats

International Journal of Medical Sciences
Eun Young RhaGyeol Yoo
January 19, 2021
Open Access

Crystal structures of glutathione- and inhibitor-bound human GGT1: critical interactions within the cysteinylglycine binding site

The Journal of Biological Chemistry
Simon S TerzyanMarie H Hanigan
January 19, 2021

Development and Implementation of a Patient Registry: The Experience of a Multiple Sclerosis Center in Portugal

Acta Médica Portuguesa
João De SáAna Macedo
January 19, 2021
Open Access

Loss of FLCN-FNIP1/2 induces a non-canonical interferon response in human renal tubular epithelial cells

Iris E GlykofridisRob Mf Wolthuis
January 19, 2021

Opposite actions of two dsRNA-binding proteins PACT and TRBP on RIG-I mediated signaling

The Biochemical Journal
Lauren S VaughnRekha C Patel
January 19, 2021

Natural killer cells in first-episode psychosis: an innate immune signature?

Molecular Psychiatry
Nadine TarantinoVincent Vieillard
January 19, 2021

Agonist of stimulator of interferon genes as antitumor agents: a patent review (2008-2020)

Expert Opinion on Therapeutic Patents
Nan-Nan ChenXiao-Li Xu
January 19, 2021

Silk Fibroin Nanoadjuvant as a Promising Vaccine Carrier to Deliver the FimH-IutA Antigen for Urinary Tract Infection

ACS Biomaterials Science & Engineering
Sara HasanzadehSaeid Bouzari
January 19, 2021

Carp edema virus and immune response in carp (Cyprinus carpio): Current knowledge

Journal of Fish Diseases
Radek MachatMartin Faldyna

Sign up to follow this feed and discover related papers.

Related Feeds

Acute viral rhinopharyngitis

Acute viral rhinopharyngitis, also known as "common cold", is an acute, self-limiting viral infection of the upper respiratory tract involving the nose, sinuses, pharynx and larynx. Discover the latest research on acute viral rhinopharyngitis here.

Argentine Hemorrhagic Fever

Argentine hemorrhagic fever (AHF) is an endemo-epidemic disease caused by junín virus (JUNV), a member of the arenaviridae family. Discover the latest research on AHF here.

BK Virus Infection

BK virus infection is a significant complication of modern immunosuppression used in kidney transplantation. Discover the latest research on BK virus infection here.


Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

COVID-19 & Diabetes (ADA)

COVID-19 (short for “Coronavirus Disease 2019") is the disease caused by the novel coronavirus, SARS-CoV-2. Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. COVID-19 represents a particular challenge to people with serious chronic medical conditions such as diabetes. To keep our community as informed as possible, the American Diabetes Association is partnering with the Chan Zuckerberg Initiative's Meta to highlight the latest research developments at the intersection of COVID-19 and diabetes.


Chickenpox is caused by the varicella-zoster virus and leads to skin rashes and blisters. This highly contagious disease can be prevented with vaccines and treated with antivirals. Discover the latest research on Chickenpox here.


Chikungunya fever is a viral disease transmitted to humans by the bite of chikungunya virus infected aedes mosquitoes. Discover the latest research on chikungunya here.

Crimean-Congo hemorrhagic fever

Crimean-Congo hemorrhagic fever (CCHF) is a potentially fatal tick-borne viral disease and one of the deadly hemorrhagic fevers.The onset of CCHF is sudden, with initial signs and symptoms including headache, high fever, back pain, joint pain, stomach pain, and vomiting. Red eyes, a flushed face, a red throat, and petechiae (red spots) on the palate are common. Discover the latest research on CCHF here.

Cytomegalovirus infection

Cytomegalovirus is a common infection among adults with little to no symptoms. Cytomegalovirus infection among immunocompromised hosts or organ transplant recipients can lead to increased morbidity and mortality. Discover the latest research here.

Dengue Virus

Dengue Virus, a mosquito transmitted pathogen, is the causative agent of dengue fever, the most important arboviral disease of humans, which affects an estimated 50-100 million people annually. Discover the latest research here.

© 2021 Meta ULC. All rights reserved