Interferon Signalling

Via interaction with their specific receptors, interferons (IFNs) activate signal transducer and activator of transcription (STAT) complexes. STAT activation initiates the classical Janus kinase-STAT (JAK-STAT) signaling pathway. In this pathway, JAKs associate with IFN receptors and, following receptor engagement with IFN, phosphorylate both STAT1 and STAT2. As a result, an IFN-stimulated gene factor 3 (ISGF3) complex forms—this contains STAT1, STAT2 and a third transcription factor called IRF9—and moves into the cell nucleus. Inside the nucleus, the ISGF3 complex binds to specific nucleotide sequences called IFN-stimulated response elements (ISREs) in the promoters of certain genes, known as IFN stimulated genes. Discover the latest research on interferon signalling here.

January 19, 2021

Cytokine Profiles Before and After Immune Modulation in Hospitalized Patients with COVID-19

Journal of Clinical Immunology
Veronica AzmyChristina C Price
January 19, 2021
Open Access

Angiotensin-Converting Enzyme Inhibitor, Captopril, Improves Scar Healing in Hypertensive Rats

International Journal of Medical Sciences
Eun Young RhaGyeol Yoo
January 19, 2021
Open Access

Crystal structures of glutathione- and inhibitor-bound human GGT1: critical interactions within the cysteinylglycine binding site

The Journal of Biological Chemistry
Simon S TerzyanMarie H Hanigan
January 19, 2021

Development and Implementation of a Patient Registry: The Experience of a Multiple Sclerosis Center in Portugal

Acta Médica Portuguesa
João De SáAna Macedo
January 19, 2021
Open Access

Loss of FLCN-FNIP1/2 induces a non-canonical interferon response in human renal tubular epithelial cells

ELife
Iris E GlykofridisRob Mf Wolthuis
January 19, 2021

Opposite actions of two dsRNA-binding proteins PACT and TRBP on RIG-I mediated signaling

The Biochemical Journal
Lauren S VaughnRekha C Patel
January 19, 2021

Natural killer cells in first-episode psychosis: an innate immune signature?

Molecular Psychiatry
Nadine TarantinoVincent Vieillard
January 19, 2021

Agonist of stimulator of interferon genes as antitumor agents: a patent review (2008-2020)

Expert Opinion on Therapeutic Patents
Nan-Nan ChenXiao-Li Xu
January 19, 2021

Silk Fibroin Nanoadjuvant as a Promising Vaccine Carrier to Deliver the FimH-IutA Antigen for Urinary Tract Infection

ACS Biomaterials Science & Engineering
Sara HasanzadehSaeid Bouzari
January 19, 2021
Review

Carp edema virus and immune response in carp (Cyprinus carpio): Current knowledge

Journal of Fish Diseases
Radek MachatMartin Faldyna

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