iPSC-derived Microglia in Neurodegeneration

Induced pluripotent stem cell-derived microglia have recently been developed and provide unlimited access to patient-derived material. These cells can be used to model and investigate the mechanism that underlie neurodegenerative diseases. This feed follows the latest research in this area using iPSC-derived microglia.

January 11, 2022
Preprint
Open Access

Microglia-secreted TNF-α affects differentiation efficiency and viability of pluripotent stem cell-derived human dopaminergic precursors

BioRxiv : the Preprint Server for Biology
S. D. WenkerFernando J Pitossi
January 8, 2022
Review

Human stem cell models of neurodegeneration: From basic science of amyotrophic lateral sclerosis to clinical translation.

Cell Stem Cell
Elisa GiacomelliLorenz Studer
January 4, 2022
Review

Ergothioneine in the brain.

FEBS Letters
Takahiro Ishimoto, Yukio Kato
January 1, 2022
Preprint
Open Access

Microglia influence neurofilament deposition in ALS iPSC-derived motor neurons

BioRxiv : the Preprint Server for Biology
R A AllisonAllison Ebert
November 23, 2021
Review
Open Access

Nicotinamide Adenine Dinucleotide Phosphate Oxidases Are Everywhere in Brain Disease, but Not in Huntington's Disease?

Frontiers in Aging Neuroscience
Luisana VillegasFrederik Vilhardt
November 2, 2021

Astrocyte Reactivity in Alzheimer's Disease: Therapeutic Opportunities to Promote Repair.

Current Alzheimer Research
Nazanin MirzaeiMagdalena Sastre
November 2, 2021
Review
Open Access

Galectins and Their Ligand Glycoconjugates in the Central Nervous System Under Physiological and Pathological Conditions.

Frontiers in Neuroanatomy
Junko Nio-Kobayashi, Tetsuya Itabashi
October 24, 2021
Review
Open Access

Glial PAMPering and DAMPening of Adult Hippocampal Neurogenesis.

Brain Sciences
Luke Parkitny, Mirjana Maletic-Savatic
October 19, 2021

Efficient and Scalable Generation of Human Ventral Midbrain Astrocytes from Human-Induced Pluripotent Stem Cells.

Journal of Visualized Experiments : JoVE
Lucy A CromptonMaeve A Caldwell
September 18, 2021
Preprint
Open Access

Genetically engineered microglia-like cells have therapeutic potential for neurodegenerative disease

BioRxiv : the Preprint Server for Biology
R. N. PlasschaertChristopher Mason
September 15, 2021
Preprint
Open Access

Synthetic amyloid beta does not induce a robust transcriptional response in innate immune cell culture systems

BioRxiv : the Preprint Server for Biology
I. Y. QuirogaDouglas H Phanstiel
September 15, 2021
Review

From psychiatry to neurology: Psychedelics as prospective therapeutics for neurodegenerative disorders.

Journal of Neurochemistry
Urszula KozlowskaMaciej Figiel
September 14, 2021
Review
Open Access

Novel Therapies for Parkinsonian Syndromes-Recent Progress and Future Perspectives.

Frontiers in Molecular Neuroscience
Dominika PrzewodowskaNatalia Madetko

Sign up to follow this feed and discover related papers.

Related Feeds

3D Cellular Models of Brain and Neurodegeneration

Brain organoids are three-dimensional in vitro cellular models of the brain that can recapitulate many processes such as the neurodevelopment. In addition, these organoids can be combined with other cell types, such as neurons and astrocytes to study their interactions in assembloids. Disease processes can also be modeled by induced pluripotent stem cell-derived organoids and assembloids from patients with neurodegenerative disorders. Discover the latest research on the models here.

ALS & FTD: TDP-43

TAR DNA-binding protein 43 (TDP-43) is a pathological protein identified in sporadic Amyotrophic Lateral Sclerosis (ALS) and Frontotemporal Dementia (FTD). Here are the latest discoveries pertaining to TDP-43 and these diseases.

ALS: Genetics

Amyotrophic Lateral Sclerosis (ALS) is a progressive neurodegenerative disorder characterized by muscle weakness. ALS is a genetically heterogeneous disorder with several causative genes. Here are the latest discoveries pertaining to the genetics of this disease.

ALS: Pathogenic Mechanisms

Amyotrophic Lateral Sclerosis is a progressive neurodegenerative disorder characterized by muscle weakness. Here is the latest research investigating pathogenic mechanisms that underlie this genetically heterogeneous disorder.

ALS: Phenotypes

Amyotrophic Lateral Sclerosis (ALS) is a neurodegenerative disorder characterized phenotypically by progressive muscle weakness. Clinical phenotypes of ALS can be classified based on the pattern, level, and area of onset (e.g. bulbar, cervical, lumbar). Here is the latest research investigating phenotypes of ALS.

ALS: Prions

Prions are misfolded proteins which characterize several fatal neurodegenerative diseases. Prion-like mechanisms are associated with the pathogenesis of Amyotrophic Lateral Sclerosis (ALS). Here is the latest research on ALS and prions.

ALS: Stress Granules

Amyotrophic Lateral Sclerosis (ALS) is a neurodegenerative disease characterized by cytoplasmic protein aggregates within motor neurons. TDP-43 is an ALS-linked protein that is known to regulate splicing and storage of specific mRNAs into stress granules, which have been implicated in formation of ALS protein aggregates. Here is the latest research in this field.

ALS: Therapies

Amyotrophic Lateral Sclerosis (ALS) is associated with the death of neurons that control voluntary muscles. This feed followes the latest research into therapies for this progressive neurodegenerative disease.

Adult Stem Cells

Adult stem cells reside in unique niches that provide vital cues for their survival, self-renewal, and differentiation. They hold great promise for use in tissue repair and regeneration as a novel therapeutic strategies. Here is the latest research.

Age-related Dementia

Dementias are a group of conditions, including Alzheimer's disease, vascular dementia, and frontotemporal dementia, characterized by deficiencies in cognitive abilities. Age-related dementia refers to dementias that occur in older individuals, usually 60+ years old, in contrast to early-onset dementia. Follow the latest research on age-related dementia here.

© 2022 Meta ULC. All rights reserved
/feed-previews/ipsc-derived-microglia-in-neurodegeneration/56250743-eb13-44c2-ac21-80159cb01278