iPSC-derived Microglia in Neurodegeneration

Induced pluripotent stem cell-derived microglia have recently been developed and provide unlimited access to patient-derived material. These cells can be used to model and investigate the mechanism that underlie neurodegenerative diseases. This feed follows the latest research in this area using iPSC-derived microglia.

January 11, 2022
Open Access

Microglia-secreted TNF-α affects differentiation efficiency and viability of pluripotent stem cell-derived human dopaminergic precursors

BioRxiv : the Preprint Server for Biology
S. D. WenkerFernando J Pitossi
January 8, 2022

Human stem cell models of neurodegeneration: From basic science of amyotrophic lateral sclerosis to clinical translation.

Cell Stem Cell
Elisa GiacomelliLorenz Studer
January 4, 2022

Ergothioneine in the brain.

FEBS Letters
Takahiro Ishimoto, Yukio Kato
January 1, 2022
Open Access

Microglia influence neurofilament deposition in ALS iPSC-derived motor neurons

BioRxiv : the Preprint Server for Biology
R A AllisonAllison Ebert
November 23, 2021
Open Access

Nicotinamide Adenine Dinucleotide Phosphate Oxidases Are Everywhere in Brain Disease, but Not in Huntington's Disease?

Frontiers in Aging Neuroscience
Luisana VillegasFrederik Vilhardt
November 2, 2021

Astrocyte Reactivity in Alzheimer's Disease: Therapeutic Opportunities to Promote Repair.

Current Alzheimer Research
Nazanin MirzaeiMagdalena Sastre
November 2, 2021
Open Access

Galectins and Their Ligand Glycoconjugates in the Central Nervous System Under Physiological and Pathological Conditions.

Frontiers in Neuroanatomy
Junko Nio-Kobayashi, Tetsuya Itabashi
October 24, 2021
Open Access

Glial PAMPering and DAMPening of Adult Hippocampal Neurogenesis.

Brain Sciences
Luke Parkitny, Mirjana Maletic-Savatic
October 19, 2021

Efficient and Scalable Generation of Human Ventral Midbrain Astrocytes from Human-Induced Pluripotent Stem Cells.

Journal of Visualized Experiments : JoVE
Lucy A CromptonMaeve A Caldwell
September 18, 2021
Open Access

Genetically engineered microglia-like cells have therapeutic potential for neurodegenerative disease

BioRxiv : the Preprint Server for Biology
R. N. PlasschaertChristopher Mason
September 15, 2021
Open Access

Synthetic amyloid beta does not induce a robust transcriptional response in innate immune cell culture systems

BioRxiv : the Preprint Server for Biology
I. Y. QuirogaDouglas H Phanstiel
September 15, 2021

From psychiatry to neurology: Psychedelics as prospective therapeutics for neurodegenerative disorders.

Journal of Neurochemistry
Urszula KozlowskaMaciej Figiel
September 14, 2021
Open Access

Novel Therapies for Parkinsonian Syndromes-Recent Progress and Future Perspectives.

Frontiers in Molecular Neuroscience
Dominika PrzewodowskaNatalia Madetko

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