iPSC-derived Microglia in Neurodegeneraton

Induced pluripotent stem cell-derived microglia have recently been developed and provide unlimited access to patient-derived material. These cells can be used to model and investigate mechanism that underlie neurodegenerative diseases. Here is the latest research.

October 6, 2020
Open Access

Novel Glial Cell Functions: Extensive Potency, Stem Cell-Like Properties, and Participation in Regeneration and Transdifferentiation

Frontiers in Cell and Developmental Biology
Valentin Milichko, Vyacheslav Dyachuk
November 21, 2020
Open Access

An in vitro bioengineered model of the human arterial neurovascular unit to study neurodegenerative diseases

Molecular Neurodegeneration
Jerome RobertCheryl Wellington
December 1, 2020
Open Access

Substrate Elasticity Exerts Functional Effects on Primary Microglia

Frontiers in Cellular Neuroscience
Stefan J BlaschkeMaria A Rueger
December 11, 2020
Open Access

Leptin enhances adult neurogenesis and reduces pathological features in a transgenic mouse model of Alzheimer's disease

Neurobiology of Disease
Michele Longoni CalióMarimélia Aparecida Porcionatto
November 20, 2020

2,5-hexanedione induces NLRP3 inflammasome activation and neurotoxicity through NADPH oxidase-dependent pathway

Free Radical Biology & Medicine
Ruixue HuangQingshan Wang
November 18, 2020
Open Access

Adult hypothalamic neurogenesis and sleep-wake dysfunction in aging

Andrey KostinMd Noor Alam
January 6, 2021
Open Access

Complete microglia deficiency accelerates prion disease without enhancing CNS prion accumulation

BioRxiv : the Preprint Server for Biology
B. M. BradfordNeil A Mabbott
November 25, 2020
Open Access

Impact of pediatric traumatic brain injury on hippocampal neurogenesis

Neural Regeneration Research
Mariam RizkZhi Zhang
December 29, 2020
Open Access

Honing the Double-Edged Sword: Improving Human iPSC-Microglia Models

Frontiers in Immunology
Anne HedegaardSally A Cowley
December 31, 2020
Open Access

ApoE4-carrying Human Astrocytes Oversupply Cholesterol into Neurons and Promote Aβ Generation

Se-In LeeJinsoo Seo
November 20, 2020
Open Access

Human iPSC-derived astrocytes transplanted into the mouse brain display three morphological responses to amyloid-β plaques

BioRxiv : the Preprint Server for Biology
Pranav PremanAmaia M Arranz
December 19, 2020

Potential neuron-autonomous Purkinje cell degeneration by 2',3'-cyclic nucleotide 3'-phosphodiesterase promoter/Cre-mediated autophagy impairments

FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology
Young Rae JoHwan Tae Park
November 5, 2020
Open Access

An in vitro bioengineered model of the human arterial neurovascular unit to study neurodegenerative diseases

Jerome RobertCheryl Wellington
January 20, 2021
Open Access

Role of miRNAs shuttled by mesenchymal stem cell-derived small extracellular vesicles in modulating neuroinflammation.

Scientific Reports
Debora GiuntiAntonio Uccelli
December 4, 2020

Metabolic and immune dysfunction of glia in neurodegenerative disorders: focus on iPSC models

Stem Cells
Taisia RõlovaJari Koistinaho
October 15, 2020

Glial restricted precursor cells in central nervous system disorders: Current applications and future perspectives

Joana Martins-MacedoLuísa Pinto
December 6, 2020
Open Access

Glia in Neurodegeneration: The Housekeeper, the Defender and the Perpetrator

International Journal of Molecular Sciences
Carrie SheelerMarija Cvetanovic
October 17, 2020
Open Access

Human iPSC-Based Models for the Development of Therapeutics Targeting Neurodegenerative Lysosomal Storage Diseases

Frontiers in Molecular Biosciences
Marco LucianiVasco Meneghini

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