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iPSC Isogenic Models of Disease

iPSC Isogenic Models of Disease diagram by Mz888ms
Mz888ms

Differences in genetic backgrounds pose a limitation to studying and inferring genetic mechanisms of diseases. These limitations can be overcome using induced pluripotent stem cell-derived isogenic models of diseases. Here is the latest research.

Top 20 most recent papers
Nature Communications

Single cell census of human kidney organoids shows reproducibility and diminished off-target cells after transplantation

Nature CommunicationsNovember 29, 2019
Ayshwarya SubramanianAnna Greka
61
1
Neuron

A Large Panel of Isogenic APP and PSEN1 Mutant Human iPSC Neurons Reveals Shared Endosomal Abnormalities Mediated by APP β-CTFs, Not Aβ

NeuronDecember 4, 2019
Dylan KwartMarc Tessier-Lavigne
1
bioRxiv

Gorlin syndrome-induced pluripotent stem cells form medulloblastoma with loss of heterozygosity in PTCH1

bioRxivNovember 29, 2019
Yu IkemotoAkihiro Umezawa
2
Nature Genetics

Neuronal impact of patient-specific aberrant NRXN1α splicing

Nature GeneticsDecember 1, 2019
Erin FlahertyKristen J Brennand
63
1
Proceedings of the National Academy of Sciences of the United States of America

Human iPSC-derived microglia assume a primary microglia-like state after transplantation into the neonatal mouse brain

Proceedings of the National Academy of Sciences of the United States of AmericaNovember 26, 2019
Devon S SvobodaRudolf Jaenisch
35
1
bioRxiv

NLRP7 Plays A Functional Role in Regulating BMP4 Signaling During Differentiation of Patient-Derived Trophoblasts

bioRxivNovember 24, 2019
Aybuke GaripcanNesrin Özören
12
Clinical Cancer Research : an Official Journal of the American Association for Cancer Research

A Virus-Infected, Reprogrammed Somatic cell-derived Tumor cell (VIReST) vaccination regime can prevent initiation and progression of pancreatic cancer

Clinical Cancer Research : an Official Journal of the American Association for Cancer ResearchNovember 25, 2019
Shuanshuang LuYao-He Wang
12
8
Journal of Hepatology

The Phosphatidylethanolamine Biosynthesis Pathway Provides a New Target for Cancer Chemotherapy

Journal of HepatologyNovember 21, 2019
Yuan GuanGary Peltz
17
Cellular and Molecular Life Sciences : CMLS

Stem cell-derived kidney organoids: engineering the vasculature

Cellular and Molecular Life Sciences : CMLSDecember 5, 2019
Marije KoningTon Johannes Rabelink
Nature Reviews. Neuroscience

Amyloid-β-independent regulators of tau pathology in Alzheimer disease

Nature Reviews. NeuroscienceNovember 28, 2019
Rik van der KantRik Ossenkoppele
109
1
Frontiers in Immunology

Natural Killer Cells Prevent the Formation of Teratomas Derived From Human Induced Pluripotent Stem Cells

Frontiers in ImmunologyNovember 7, 2019
Basma Fattouma BenabdallahChristian M Beauséjour
1
Frontiers in Medicine

iPSC-Derived Hepatocytes as a Platform for Disease Modeling and Drug Discovery

Frontiers in MedicineNovember 15, 2019
James L Corbett, Stephen A Duncan
PloS One

Generation of targeted homozygosity in the genome of human induced pluripotent stem cells

PloS OneDecember 5, 2019
Yasuhide YoshimuraJunji Takeda
2
Annals of Translational Medicine

Human-animal chimeras for autologous organ transplantation: technological advances and future perspectives

Annals of Translational MedicineOctober 1, 2019
Ying-fei LuJian-quan Chen
International Journal of Molecular Sciences

Stem Cells: The Game Changers of Human Cardiac Disease Modelling and Regenerative Medicine

International Journal of Molecular SciencesNovember 16, 2019
Elvira Immacolata ParrottaGiovanni Cuda
3
Biomedicines

Stem Cell Surgery and Growth Factors in Retinitis Pigmentosa Patients: Pilot Study after Literature Review

BiomedicinesNovember 30, 2019
Paolo Giuseppe LimoliMarcella Nebbioso
4
Human Reproduction

Human induced pluripotent stem cells from two azoospermic patients with Klinefelter syndrome show similar X chromosome inactivation behavior to female pluripotent stem cells

Human ReproductionNovember 19, 2019
Sarita Pauliina PanulaJan-bernd Stukenborg
8
Stem Cell Research & Therapy

Synergistic modulation of signaling pathways to expand and maintain the bipotency of human hepatoblasts

Stem Cell Research & TherapyDecember 2, 2019
Ting-Cai PanYin-Xiong Li
2
Oxidative Medicine and Cellular Longevity

Neuroprotection of Indole-Derivative Compound NC001-8 by the Regulation of the NRF2 Pathway in Parkinson's Disease Cell Models

Oxidative Medicine and Cellular LongevityOctober 31, 2019
Pei-Cih WeiKuo-Hsuan Chang
1
1
The EMBO Journal

LIN28A loss of function is associated with Parkinson's disease pathogenesis

The EMBO JournalNovember 21, 2019
Mi-Yoon ChangSang-Hun Lee
8
1

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