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iPSC Isogenic Models of Disease

iPSC Isogenic Models of Disease diagram by Massa et al, PLOS One
Massa et al, PLOS One

Differences in genetic backgrounds pose a limitation to studying and inferring genetic mechanisms of diseases. These limitations can be overcome using induced pluripotent stem cell-derived isogenic models of diseases. Here is the latest research.

Top 20 most recent papers
Nature Genetics

Modeling the complex genetic architectures of brain disease

Nature GeneticsMarch 24, 2020
Michael B FernandoKristen J Brennand
49
2
ACS Chemical Neuroscience

Differentiation of intrafusal fibers from human induced pluripotent stem cells

ACS Chemical NeuroscienceMarch 12, 2020
Alisha ColónJames J Hickman
1
Journal of the American Heart Association

Cumulative Lifetime Burden of Cardiovascular Disease From Early Exposure to Air Pollution

Journal of the American Heart AssociationMarch 17, 2020
Juyong Brian KimKari C Nadeau
6
1
1
International Journal of Molecular Sciences

Recent Overview of the Use of iPSCs Huntington's Disease Modeling and Therapy

International Journal of Molecular SciencesMarch 28, 2020
Maria CsobonyeiovaLubos Danisovic
Journal of the American Heart Association

Exosomes From Induced Pluripotent Stem Cell-Derived Cardiomyocytes Promote Autophagy for Myocardial Repair

Journal of the American Heart AssociationMarch 6, 2020
Michelle R SantosoPhillip C Yang
4
Frontiers in Cell and Developmental Biology

Patient-Specific Retinal Organoids Recapitulate Disease Features of Late-Onset Retinitis Pigmentosa

Frontiers in Cell and Developmental BiologyMarch 27, 2020
Mei-Ling GaoZi-Bing Jin
3
Journal of the American Society of Nephrology : JASN

Use of Human Induced Pluripotent Stem Cells and Kidney Organoids To Develop a Cysteamine/mTOR Inhibition Combination Therapy for Cystinosis

Journal of the American Society of Nephrology : JASNMarch 22, 2020
Jennifer A HollywoodTeresa M Holm
11

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