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iPSC Isogenic Models of Disease

iPSC Isogenic Models of Disease diagram by Mz888ms

Differences in genetic backgrounds pose a limitation to studying and inferring genetic mechanisms of diseases. These limitations can be overcome using induced pluripotent stem cell-derived isogenic models of diseases. Here is the latest research.

Top 20 most recent papers
Nature Communications

Single cell census of human kidney organoids shows reproducibility and diminished off-target cells after transplantation

Nature CommunicationsNovember 29, 2019
Ayshwarya SubramanianAnna Greka

A Large Panel of Isogenic APP and PSEN1 Mutant Human iPSC Neurons Reveals Shared Endosomal Abnormalities Mediated by APP β-CTFs, Not Aβ

NeuronDecember 4, 2019
Dylan KwartMarc Tessier-Lavigne

Gorlin syndrome-induced pluripotent stem cells form medulloblastoma with loss of heterozygosity in PTCH1

bioRxivNovember 29, 2019
Yu IkemotoAkihiro Umezawa
Nature Genetics

Neuronal impact of patient-specific aberrant NRXN1α splicing

Nature GeneticsDecember 1, 2019
Erin FlahertyKristen J Brennand
Proceedings of the National Academy of Sciences of the United States of America

Human iPSC-derived microglia assume a primary microglia-like state after transplantation into the neonatal mouse brain

Proceedings of the National Academy of Sciences of the United States of AmericaNovember 26, 2019
Devon S SvobodaRudolf Jaenisch

NLRP7 Plays A Functional Role in Regulating BMP4 Signaling During Differentiation of Patient-Derived Trophoblasts

bioRxivNovember 24, 2019
Aybuke GaripcanNesrin Özören
Clinical Cancer Research : an Official Journal of the American Association for Cancer Research

A Virus-Infected, Reprogrammed Somatic cell-derived Tumor cell (VIReST) vaccination regime can prevent initiation and progression of pancreatic cancer

Clinical Cancer Research : an Official Journal of the American Association for Cancer ResearchNovember 25, 2019
Shuanshuang LuYao-He Wang
Journal of Hepatology

The Phosphatidylethanolamine Biosynthesis Pathway Provides a New Target for Cancer Chemotherapy

Journal of HepatologyNovember 21, 2019
Yuan GuanGary Peltz
Cellular and Molecular Life Sciences : CMLS

Stem cell-derived kidney organoids: engineering the vasculature

Cellular and Molecular Life Sciences : CMLSDecember 5, 2019
Marije KoningTon Johannes Rabelink
Nature Reviews. Neuroscience

Amyloid-β-independent regulators of tau pathology in Alzheimer disease

Nature Reviews. NeuroscienceNovember 28, 2019
Rik van der KantRik Ossenkoppele
Frontiers in Immunology

Natural Killer Cells Prevent the Formation of Teratomas Derived From Human Induced Pluripotent Stem Cells

Frontiers in ImmunologyNovember 7, 2019
Basma Fattouma BenabdallahChristian M Beauséjour
Frontiers in Medicine

iPSC-Derived Hepatocytes as a Platform for Disease Modeling and Drug Discovery

Frontiers in MedicineNovember 15, 2019
James L Corbett, Stephen A Duncan
PloS One

Generation of targeted homozygosity in the genome of human induced pluripotent stem cells

PloS OneDecember 5, 2019
Yasuhide YoshimuraJunji Takeda
Annals of Translational Medicine

Human-animal chimeras for autologous organ transplantation: technological advances and future perspectives

Annals of Translational MedicineOctober 1, 2019
Ying-fei LuJian-quan Chen
International Journal of Molecular Sciences

Stem Cells: The Game Changers of Human Cardiac Disease Modelling and Regenerative Medicine

International Journal of Molecular SciencesNovember 16, 2019
Elvira Immacolata ParrottaGiovanni Cuda

Stem Cell Surgery and Growth Factors in Retinitis Pigmentosa Patients: Pilot Study after Literature Review

BiomedicinesNovember 30, 2019
Paolo Giuseppe LimoliMarcella Nebbioso
Human Reproduction

Human induced pluripotent stem cells from two azoospermic patients with Klinefelter syndrome show similar X chromosome inactivation behavior to female pluripotent stem cells

Human ReproductionNovember 19, 2019
Sarita Pauliina PanulaJan-bernd Stukenborg
Stem Cell Research & Therapy

Synergistic modulation of signaling pathways to expand and maintain the bipotency of human hepatoblasts

Stem Cell Research & TherapyDecember 2, 2019
Ting-Cai PanYin-Xiong Li
Oxidative Medicine and Cellular Longevity

Neuroprotection of Indole-Derivative Compound NC001-8 by the Regulation of the NRF2 Pathway in Parkinson's Disease Cell Models

Oxidative Medicine and Cellular LongevityOctober 31, 2019
Pei-Cih WeiKuo-Hsuan Chang
The EMBO Journal

LIN28A loss of function is associated with Parkinson's disease pathogenesis

The EMBO JournalNovember 21, 2019
Mi-Yoon ChangSang-Hun Lee

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