iPSC Isogenic Models of Disease

Differences in genetic backgrounds pose a limitation to studying and inferring genetic mechanisms of diseases. These limitations can be overcome using induced pluripotent stem cell-derived isogenic models of diseases. Here is the latest research.

January 14, 2022
Comment / Editorial

in vitro models of human mast cells: How to get more and better with induced pluripotent stem cells?

The Journal of Allergy and Clinical Immunology
Laurent L'homme, David Dombrowicz
January 14, 2022

Inhibiting mitochondrial fission rescues degeneration in hereditary spastic paraplegia neurons.

Brain : a Journal of Neurology
Zhenyu ChenXue-Jun Li
January 14, 2022

Stage-Specific Generation of Human Pluripotent Stem Cell Derived Lung Models to Measure CFTR Function.

Current Protocols
Shuk Yee NganAmy P Wong
January 14, 2022

Skin Mirrors Brain: A Chance for Alzheimer's Disease Research.

Advances in Experimental Medicine and Biology
Christos C ZouboulisAmir M Hossini
January 13, 2022

Motor neuron replacement therapy for amyotrophic lateral sclerosis.

Neural Regeneration Research
Bochao LiuPaul Lu
January 13, 2022

MicroRNA-365 regulates human cardiac action potential duration.

Nature Communications
Dena EsfandyariStefan Engelhardt
January 13, 2022

Comprehensive analysis of prime editing outcomes in human embryonic stem cells.

Nucleic Acids Research
Omer HabibSangsu Bae
January 13, 2022

[Adrenal glands stem cells: general signaling pathways].

Problemy e̊ndokrinologii
O V GlazovaP Y Volchkov
January 13, 2022

Human airway lineages derived from pluripotent stem cells reveal the epithelial responses to SARS-CoV-2 infection.

American Journal of Physiology. Lung Cellular and Molecular Physiology
Ruobing WangFinn J Hawkins
January 12, 2022
Open Access

Efficient generation of lower induced Motor Neurons by coupling Ngn2 expression with developmental cues

BioRxiv : the Preprint Server for Biology
Francesco LimoneK. Eggan
January 12, 2022
Open Access

Human iPSC-Derived Astrocytes: A Powerful Tool to Study Primary Astrocyte Dysfunction in the Pathogenesis of Rare Leukodystrophies.

International Journal of Molecular Sciences
Angela LanciottiElena Ambrosini
January 12, 2022
Open Access

In Vitro and In Vivo Models to Study Nephropathic Cystinosis.

Pang Yuk CheungJennifer A Hollywood

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