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iPSC Isogenic Models of Disease

iPSC Isogenic Models of Disease diagram by Massa et al, PLOS One
Massa et al, PLOS One

Differences in genetic backgrounds pose a limitation to studying and inferring genetic mechanisms of diseases. These limitations can be overcome using induced pluripotent stem cell-derived isogenic models of diseases. Here is the latest research.

Top 20 most recent papers
Science Translational Medicine

GDNF rescues the fate of neural progenitor grafts by attenuating Notch signals in the injured spinal cord in rodents

Science Translational MedicineJanuary 10, 2020
Mohamad KhazaeiMichael G Fehlings
20
2
Scientific Reports

Efficient generation of thymic epithelium from induced pluripotent stem cells that prolongs allograft survival

Scientific ReportsJanuary 16, 2020
Ryo OtsukaKen-Ichiro Seino
7
2
Scientific Reports

Troponin destabilization impairs sarcomere-cytoskeleton interactions in iPSC-derived cardiomyocytes from dilated cardiomyopathy patients

Scientific ReportsJanuary 16, 2020
Yuanyuan DaiAntje Ebert
8
Scientific Reports

Encapsulation boosts islet-cell signature in differentiating human induced pluripotent stem cells via integrin signalling

Scientific ReportsJanuary 17, 2020
Thomas Aga LegøySimona Chera
3
2
Nature Communications

Generation of mesenchyme free intestinal organoids from human induced pluripotent stem cells

Nature CommunicationsJanuary 12, 2020
Aditya MithalGustavo Mostoslavsky
50
6
2
Biosensors & Bioelectronics

Total Microfluidic chip for Multiplexed diagnostics (ToMMx)

Biosensors & BioelectronicsJanuary 14, 2020
Mehmet O OzenUtkan Demirci
4
bioRxiv

Variant-specific changes in persistent or resurgent Na+ current in SCN8A-EIEE13 iPSC-derived neurons

bioRxivJanuary 18, 2020
Andrew M TidballJack M Parent
1
International Journal of Molecular Sciences

Clinical Trials of Limbal Stem Cell Deficiency Treated with Oral Mucosal Epithelial Cells

International Journal of Molecular SciencesJanuary 16, 2020
Joan OlivaYutaka Niihara
bioRxiv

Human iPS Cells Derived Skeletal Muscle Progenitor Cells Promote Myoangiogenesis and Restore Dystrophin in Duchenne Muscular Dystrophic Mice

bioRxivJanuary 21, 2020
wanling xuanMuhammad Ashraf
Journal of Biomedical Materials Research. Part B, Applied Biomaterials

Thermosensitive hydrogels loaded with human-induced pluripotent stem cells overexpressing growth differentiation factor-5 ameliorate intervertebral disc degeneration in rats

Journal of Biomedical Materials Research. Part B, Applied BiomaterialsJanuary 14, 2020
Annan HuJian Dong
Disease Models & Mechanisms

Modelling the pathogenesis of X-linked distal hereditary motor neuropathy using patient-derived iPSCs

Disease Models & MechanismsJanuary 24, 2020
Gonzalo Perez-SilesMarina L Kennerson
International Journal of Molecular Sciences

Human Induced Pluripotent Stem Cells Derived from a Cardiac Somatic Source: Insights for an In-Vitro Cardiomyocyte Platform

International Journal of Molecular SciencesJanuary 17, 2020
Alessandra Maria LodriniClaudia Altomare
9
Current Stem Cell Research & Therapy

Uncovering the Diversification of Tissue Engineering on the Emergent Areas of Stem Cells, Nanotechnology and Biomaterials

Current Stem Cell Research & TherapyJanuary 21, 2020
Sunil Kumar DubeyRicha Dayaramani
Annals of Translational Medicine

A compendious summary of Parkinson's disease patient-derived iPSCs in the first decade

Annals of Translational MedicineJanuary 14, 2020
Chao RenChun-Feng Liu
1
Human Molecular Genetics

Adaptor protein complex 4 deficiency: a paradigm of childhood-onset hereditary spastic paraplegia caused by defective protein trafficking

Human Molecular GeneticsJanuary 10, 2020
Robert BehneDarius Ebrahimi-Fakhari
1
International Journal of Molecular Sciences

Progress of Induced Pluripotent Stem Cell Technologies to Understand Genetic Epilepsy

International Journal of Molecular SciencesJanuary 17, 2020
Bruno SterliniAnna Corradi
1
Hepatology : Official Journal of the American Association for the Study of Liver Diseases

Non-phagocytic Activation of NOX2 is Implicated in Progressive Non-alcoholic Steatohepatitis During Aging

Hepatology : Official Journal of the American Association for the Study of Liver DiseasesJanuary 18, 2020
Joy X JiangN J Török
3
Advanced Drug Delivery Reviews

Towards chamber specific heart-on-a-chip for drug testing applications

Advanced Drug Delivery ReviewsJanuary 10, 2020
Yimu ZhaoMilica Radisic
3
1
Disease Models & Mechanisms

Addressing variability in iPSC-derived models of human disease: guidelines to promote reproducibility

Disease Models & MechanismsJanuary 19, 2020
Viola Volpato, Caleb Webber
bioRxiv

Cell-type specific impact of glucocorticoid receptor activation on the developing brain

bioRxivJanuary 9, 2020
Cristiana CruceanuElisabeth Binder
41

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