iPSC Models in Neurodegeneration

Induced pluripotent stem cell (iPSCs) models can be generated to study mechanisms involved in neurodegeneration. The iPSCs can be selectively differentiated into specific neurons such as dopaminergic neurons that are susceptible to neurodegeneration. Discover the latest research on iPSC models in neurodegeneration here.

April 16, 2021
Preprint
Open Access

The Alzheimer's disease risk factor APOE4 drives pro-inflammation in human astrocytes via HDAC-dependent repression of TAGLN3

BioRxiv : the Preprint Server for Biology
L. ArnaudEmmanuel Nivet
April 16, 2021

Identification of hub molecules of FUS-ALS by Bayesian gene regulatory network analysis of iPSC model: iBRN.

Neurobiology of Disease
Masahiro NogamiHideyuki Okano
April 11, 2021
Open Access

APOE2 mitigates disease-related phenotypes in an isogenic hiPSC-based model of Alzheimer's disease.

Molecular Psychiatry
Nicholas BrookhouserDavid A Brafman
April 11, 2021

Human Induced Pluripotent Stem Cell (iPSC) Handling Protocols: Maintenance, Expansion, and Cryopreservation.

Methods in Molecular Biology
Davide MarottaValentina Fossati
April 8, 2021
Review
Open Access

Novel approaches to liver disease diagnosis and modeling.

Translational Gastroenterology and Hepatology
André G Oliveira, Romina Fiorotto
April 5, 2021
Open Access

Transplantation of miPSC/mESC-derived retinal ganglion cells into healthy and glaucomatous retinas.

Molecular Therapy. Methods & Clinical Development
Julia OswaldPetr Baranov
April 5, 2021
Open Access

Rapid and Efficient Generation of Myelinating Human Oligodendrocytes in Organoids.

Frontiers in Cellular Neuroscience
Mohammed R ShakerErnst J Wolvetang
April 4, 2021
Review
Open Access

Current State-of-the-Art and Unresolved Problems in Using Human Induced Pluripotent Stem Cell-Derived Dopamine Neurons for Parkinson's Disease Drug Development.

International Journal of Molecular Sciences
S A Antonov, E V Novosadova
April 3, 2021
Review
Open Access

Varicella-Zoster Virus Infection of Neurons Derived from Neural Stem Cells.

Viruses
Peter G E Kennedy, Trine H Mogensen
April 3, 2021
Review
Open Access

Modelling Parkinson's Disease: iPSCs towards Better Understanding of Human Pathology.

Brain Sciences
Sahar AvazzadehLeo R Quinlan
March 31, 2021
Review

Homocysteine and Gliotoxicity.

Neurotoxicity Research
Angela T S WyseAndré Quincozes-Santos
March 31, 2021
Open Access

Astrocytic atrophy as a pathological feature of Parkinson's disease with LRRK2 mutation.

NPJ Parkinson's Disease
Paula Ramos-GonzalezFabio Cavaliere
March 29, 2021
Preprint
Open Access

Functional expression of the ATP-gated P2X7 receptor in human iPSC-derived neurons and astrocytes

BioRxiv : the Preprint Server for Biology
J. KesavanTobias Engel
March 30, 2021
Review
Open Access

Induced Neurons for Disease Modeling and Repair: A Focus on Non-fibroblastic Cell Sources in Direct Reprogramming.

Frontiers in Bioengineering and Biotechnology
Kathryn M KimRobert A Marr
March 29, 2021

Human Pluripotent Stem Cell Differentiation to Microglia.

Methods in Molecular Biology
Laraib IjazValentina Fossati
March 28, 2021
Preprint
Open Access

Continuous monitoring reveals protective effects of N-acetylcysteine amide on an isogenic microphysiological model of the neurovascular unit

BioRxiv : the Preprint Server for Biology
I. MatthiesenA. Herland

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