Neurodegeneration: iPSCs

Neurodegeneration is the progressive loss of structure or function of neurons, including neuronal death. Several diseases, including Alzheimer’s and Parkinson’s disease, occur as a result of neurodegeneration. This feed focuses on the utility of induced pluripotent stem cells in neurodegenerative disorders.

December 30, 2020
Review
Open Access

Evolution of Adrenoleukodystrophy Model Systems

Journal of Inherited Metabolic Disease
Roberto MontoroMarc Engelen
January 9, 2021
Open Access

Exifone Is a Potent HDAC1 Activator with Neuroprotective Activity in Human Neuronal Models of Neurodegeneration

ACS Chemical Neuroscience
Debasis PatnaikStephen J Haggarty
December 20, 2020

A Synergistic Engineering Approach to Build Human Brain Spheroids

Methods in Molecular Biology
Djuna von Maydell, Mehdi Jorfi
January 18, 2021
Preprint
Open Access

Histone Deacetylase 2 (HDAC2) influences maturation and mitochondrial dynamics in human induced pluripotent stem cell derived neurons.

BioRxiv : the Preprint Server for Biology
H. FrankowskiJessica E. Young
January 9, 2021
Open Access

Presence of a mutation in PSEN1 or PSEN2 gene is associated with an impaired brain endothelial cell phenotype in vitro

Fluids and Barriers of the CNS
Snehal RautAbraham Al-Ahmad
January 12, 2021
Review
Open Access

Dysregulation of Neuronal Calcium Signaling via Store-Operated Channels in Huntington's Disease

Frontiers in Cell and Developmental Biology
Magdalena Czeredys
December 29, 2020
Review
Open Access

Honing the Double-Edged Sword: Improving Human iPSC-Microglia Models

Frontiers in Immunology
Anne HedegaardSally A Cowley
January 16, 2021

Advances in CNS organoids: a focus on organoid-based models for motor neuron disease

Tissue Engineering. Part C, Methods
Renata Vieira de SaJeroen Pasterkamp
January 8, 2021
Preprint
Open Access

Identification of hub molecules of FUS-ALS by Bayesian gene regulatory network analysis of iPSC model: iBRN

BioRxiv : the Preprint Server for Biology
M. NogamiHideyuki Okano
December 29, 2020
Open Access

LSM12-EPAC1 defines a neuroprotective pathway that sustains the nucleocytoplasmic RAN gradient

PLoS Biology
Jongbo LeeChunghun Lim
December 31, 2020
Preprint
Open Access

ApoE4-carrying Human Astrocytes Oversupply Cholesterol into Neurons and Promote Aβ Generation

ResearchSquare
Se-In LeeJinsoo Seo
January 8, 2021

Ceramide contributes to pathogenesis and may be targeted for therapy in VCP inclusion body myopathy

Human Molecular Genetics
Lan WeissVirginia Kimonis
January 8, 2021
Preprint
Open Access

Enhanced detection of nucleotide repeat mRNA with hybridization chain reaction

BioRxiv : the Preprint Server for Biology
M. R. GlineburgPeter Todd
January 13, 2021

A Multi-omics Data Resource for Frontotemporal Dementia Research

Advances in Experimental Medicine and Biology
Peter HeutinkAnupriya Dalmia

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