JAK/STAT & Metabolism

The JAK/STAT signaling pathways is important for various processes including immunity, cell division, cell death, and tumor formation. Recent data has implicated this pathway in metabolic diseases including type 2 diabetes and obesity. Here is the latest research.

September 7, 2020
Open Access

Biological Network Model of Effect of Chronic Intermittent Hypoxia on Spermatogenesis in Rats

Medical Science Monitor : International Medical Journal of Experimental and Clinical Research
Jisheng WangBin Wang
September 28, 2020

Effects of aerobic exercise and resveratrol on the expressions of JAK2 and TGF-β1 in renal tissue of type 2 diabetes rats

Zhongguo ying yong sheng li xue za zhi = Zhongguo yingyong shenglixue zazhi = Chinese journal of applied physiology
Xiao Juan SunWei Li Jiang
August 18, 2020

Novel therapeutic agents for the treatment of diabetic kidney disease

Expert Opinion on Investigational Drugs
Rachel E HartmanSusan J Lewis
October 14, 2020

Targeting Drugs Against Fibroblast Growth Factor(s)-Induced Cell Signaling

Current Drug Targets
Shilpi AgrawalThallapuranam Krishnaswamy Suresh Kumar
November 13, 2020
Open Access

Examining the Frequency of the JAK2 (V617F) Mutation in Patients with Myeloproliferative Diseases in North Eastern Iran and the Effect of Treatment Intervention

Reports of Biochemistry & Molecular Biology
Mojila NasseriMohammad Reza Abbaszadegan
January 13, 2021
Open Access

Growth Hormone Signaling Pathway Leading to the Induction of DNA Synthesis and Proliferation in Primary Cultured Hepatocytes of Adult Rats

Journal of Pharmacy & Pharmaceutical Sciences : a Publication of the Canadian Society for Pharmaceutical Sciences, Société Canadienne Des Sciences Pharmaceutiques
Mitsutoshi KimuraMasahiko Ogihara
January 16, 2021

Aberrant type 1 immunity drives susceptibility to mucosal fungal infections

Science
Timothy J BreakMichail S Lionakis
November 28, 2020

Circadian clock disruption attenuated growth hormone(GH)-mediated signalling

General and Comparative Endocrinology
Xintong LyuLan Wu
October 7, 2020
Open Access

The Relationship between Leptin, the Leptin Receptor and FGFR1 in Primary Human Breast Tumors

Cells
Wyatt Boothby-ShoemakerJamie J Bernard
October 4, 2020

Ocular surface diabetic disease: A neurogenic condition?

The Ocular Surface
Antonio Di ZazzoStefano Bonini
October 27, 2020
Open Access

JAK Inhibitors Suppress Cancer Cachexia-Associated Anorexia and Adipose Wasting in Mice

JCSM Rapid Communications
Gurpreet AroraRodney Infante
November 17, 2020
Open Access

Nanoparticle-Mediated Delivery of 2-Deoxy-D-Glucose Induces Antitumor Immunity and Cytotoxicity in Liver Tumors in Mice

Cellular and Molecular Gastroenterology and Hepatology
Kyo SasakiKeisuke Hino
September 5, 2020
Open Access

Extramyocellular interleukin-6 influences skeletal muscle mitochondrial physiology through canonical JAK/STAT signaling pathways

FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology
Hinnah AbidIan R Lanza
December 19, 2020

Chronic exposure to methylmercury enhances the anorexigenic effects of leptin in C57BL/6J male mice

Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association
Beatriz FerrerMichael Aschner

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