KEAP1-NRF2 in Cancer

NRF2 is primarily regulated by KEAP1 and is implicated in protecting cancer cells from chemotherapy and plays a role in cancer progression. Here is the latest research on KEAP1-NRF2 signal transduction pathway.

July 12, 2020

Discovery of 4-Anilinoquinolinylchalcone Derivatives as Potential NRF2 Activators

Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry
Yu-Tse KaoYeh-Long Chen
July 2, 2020
Open Access

BDH2 triggers ROS-induced cell death and autophagy by promoting Nrf2 ubiquitination in gastric cancer

Journal of Experimental & Clinical Cancer Research : CR
Jia-Zhou LiuWan-Jiang Xue
July 8, 2020

Knockdown of p66ShcA activates Nrf2 pathway to protect cardiomyocytes from oxidative stress and inflammation induced by H2O2

European Review for Medical and Pharmacological Sciences
B LiuY-Z Xue
June 24, 2020

The effect of monotropein on alleviating cisplatin-induced acute kidney injury by inhibiting oxidative damage, inflammation and apoptosis

Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie
Yuping ZhangXiujie Sheng
June 24, 2020
Open Access

KEAP1, a cysteine-based sensor and a drug target for the prevention and treatment of chronic disease

Open Biology
Sharadha Dayalan Naidu, Albena T Dinkova-Kostova
June 25, 2020
Open Access

Loss-of-function mutations in KEAP1 drive lung cancer progression via KEAP1/NRF2 pathway activation

Cell Communication and Signaling : CCS
Meiling GongCuixia Zheng
June 24, 2020
Open Access

NRF2-Driven KEAP1 Transcription in Human Lung Cancer

Molecular Cancer Research : MCR
Yijun TianLiang Wang
June 17, 2020

NR5A2 synergizes with NCOA3 to induce breast cancer resistance to BET inhibitor by upregulating NRF2 to attenuate ferroptosis

Biochemical and Biophysical Research Communications
Jianghua QiaoZhengzhi Zou
June 24, 2020

Electrophilic nitrated fatty acids are potential therapeutic candidates for inflammatory and fibrotic lung diseases

Nitric Oxide : Biology and Chemistry
Kalpana PanatiVenkata Ramireddy Narala
July 1, 2020
Open Access

Bardoxolone methyl: drug development for diabetic kidney disease

Clinical and Experimental Nephrology
Hironori Kanda, Kengo Yamawaki
June 20, 2020

Hirudin protects against isoproternol-induced myocardial infraction by alleviating oxidative via an Nrf2 dependent manner

International Journal of Biological Macromolecules
Haowen ZhangYun Tsai
July 1, 2020
Open Access

Effects of Compound Centella on Oxidative Stress and Keap1-Nrf2-ARE Pathway Expression in Diabetic Kidney Disease Rats

Evidence-based Complementary and Alternative Medicine : ECAM
Qin ZhuHongyu Chen

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