KEAP1-NRF2 in Cancer

NRF2 is primarily regulated by KEAP1 and is implicated in protecting cancer cells from chemotherapy and plays a role in cancer progression. Here is the latest research on KEAP1-NRF2 signal transduction pathway.

December 17, 2020

LKB1 mutations in NSCLC are associated with KEAP1/NRF2-dependent radiotherapy resistance targetable by glutaminase inhibition

Clinical Cancer Research : an Official Journal of the American Association for Cancer Research
Piyada SitthideatphaiboonJohn V Heymach
January 10, 2021
Open Access

Exome of Radiation-induced Rat Mammary Carcinoma Shows Copy-number Losses and Mutations in Human-relevant Cancer Genes

Anticancer Research
Hitomi MorimyamaShizuko Kakinuma
December 31, 2020
Open Access

Hybrid E/M Phenotype(s) and Stemness: A Mechanistic Connection Embedded in Network Topology

Journal of Clinical Medicine
Satwik PasaniMohit Kumar Jolly
December 19, 2020
Review
Open Access

Myricetin: A review of the most recent research

Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie
Xiaominting SongJin Pei
December 19, 2020
Open Access

Mining Natural Products for Macrocycles to Drug Difficult Targets

Journal of Medicinal Chemistry
Fabio BegniniJan Kihlberg
January 9, 2021
Preprint
Open Access

Aberrant ROS Served as an Acquired Vulnerability of Cisplatin-resistant Lung Cancer

ResearchSquare
Qian XinJupeng Yuan
December 22, 2020
Review
Open Access

Pharmacological Effects of Salvianolic Acid B Against Oxidative Damage

Frontiers in Pharmacology
Zhun XiaoPing Liu
January 8, 2021
Open Access

Merlin deficiency alters the redox management program in breast cancer

Molecular Oncology
Mateus MotaLalita A Shevde
December 21, 2020

Palliative Sedation at the End of Life: A Comparative Study of Chronic Obstructive Pulmonary Disease and Lung Cancer Patients

Respiration; International Review of Thoracic Diseases
Elena TejeroFrancisco García-Rio
January 10, 2021
Open Access

Identification of a subset of immunosuppressive P2RX1-negative neutrophils in pancreatic cancer liver metastasis

Nature Communications
Xu WangZhi-Gang Zhang
January 10, 2021
Open Access

Keap1-Nrf2 Pathway Regulates ALDH and Contributes to Radioresistance in Breast Cancer Stem Cells

Cells
Dinisha KambleSandhya Sitasawad
January 9, 2021
Open Access

ROS‑mediated hypomethylation of PRDX5 promotes STAT3 binding and activates the Nrf2 signaling pathway in NSCLC

International Journal of Molecular Medicine
Xiang CaoQun Xue
January 9, 2021
Open Access

Neferine improves oxidative stress and apoptosis in benign prostate hyperplasia via Nrf2-ARE pathway

Redox Report : Communications in Free Radical Research
Nabila JahanSicen Wang
January 5, 2021
Open Access

MOAP-1-mediated dissociation of p62/SQSTM1 bodies releases Keap1 and suppresses Nrf2 signaling

EMBO Reports
Chong Teik TanVictor C Yu
January 7, 2021

INHIBITION OF THE NRF2/KEAP1 AXIS: A PROMISING THERAPEUTIC STRATEGY TO ALTER REDOX BALANCE OF CANCER CELLS

Antioxidants & Redox Signaling
Emiliano Panieri, Luciano Saso

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