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Killing Mechanisms

Killing Mechanisms diagram by VectorMine, Shutterstock
VectorMine, Shutterstock

Cytolytic t lymphocytes exert two main specific molecular killing mechanisms against target cells, namely (i) they can synthesize and release soluble cytolytic factors, and (ii) they can express effector molecules that act as ligands of receptors expressed by target cells on the cell surface. Here is the latest research on killing mechanisms.

Top 20 most recent papers
Clinical Lung Cancer

Design and Rationale for a Phase III, Randomized, Placebo-controlled Trial of Durvalumab With or Without Tremelimumab After Concurrent Chemoradiotherapy for Patients With Limited-stage Small-cell Lung Cancer: The ADRIATIC Study

Clinical Lung CancerJanuary 18, 2020
Suresh SenanByoung Chul Cho

Human Anti-tumor Immunity: Insights from Immunotherapy Clinical Trials

ImmunityJanuary 16, 2020
Jackson G EgenLawren C Wu

Keeping T-he Killers at Bay via FcγRIIb

ImmunityJanuary 18, 2020
Falk Nimmerjahn

Dimers Aren't Forever: CD80 Breaks up with PD-L1

ImmunityJanuary 18, 2020
David M Sansom, Lucy S K Walker

Correction: BCMA peptide-engineered nanoparticles enhance induction and function of antigen-specific CD8+ cytotoxic T lymphocytes against multiple myeloma: clinical applications

LeukemiaJanuary 18, 2020
Jooeun BaeKenneth C Anderson

Multiplexed Single-cell Metabolic Profiles Organize the Spectrum of Human Cytotoxic T Cells

bioRxivJanuary 17, 2020
Felix J HartmannSean C Bendall
CA: a Cancer Journal for Clinicians

A review of cancer immunotherapy toxicity

CA: a Cancer Journal for CliniciansJanuary 17, 2020
Lucy Boyce Kennedy, April K S Salama
Cancer Research

Linking transcriptomic and imaging data defines features of a favorable tumor immune microenvironment and identifies a combination biomarker for primary melanoma

Cancer ResearchJanuary 18, 2020
Robyn D Gartrell-CorradoYvonne M Saenger
Methods in Enzymology

Assessment of IFNγ responsiveness in patient-derived xenografts

Methods in EnzymologyJanuary 18, 2020
Jordan J CardenasKaterina Politi
Science Translational Medicine

Intratumoral expression of IL-7 and IL-12 using an oncolytic virus increases systemic sensitivity to immune checkpoint blockade

Science Translational MedicineJanuary 17, 2020
Shinsuke NakaoTakafumi Nakamura
Methods in Enzymology

Assessment of IFN-γ and granzyme-B production by in "sitro" technology

Methods in EnzymologyJanuary 18, 2020
Claudia GalassiIlio Vitale
Science Immunology

Gasdermin E-mediated target cell pyroptosis by CAR T cells triggers cytokine release syndrome

Science ImmunologyJanuary 19, 2020
Yuying LiuBo Huang
Journal of Clinical Immunology

Disseminated Pneumocystis jirovecii Infection with Osteomyelitis in a Patient with CTLA-4 Haploinsufficiency

Journal of Clinical ImmunologyJanuary 20, 2020
Aminaa E SiddiqiYael Gernez
Journal of Clinical Medicine

Anti-PD-1 and Novel Combinations in the Treatment of Melanoma-An Update

Journal of Clinical MedicineJanuary 18, 2020
Frank Friedrich GellrichFriedegund Meier
International Journal of Cancer. Journal International Du Cancer

Immune checkpoint inhibitors in advanced nasopharyngeal carcinoma: beyond an era of chemoradiation?

International Journal of Cancer. Journal International Du CancerJanuary 18, 2020
Liam MastersonMatt Lechner

Human MAIT cell cytolytic effector proteins synergize to overcome carbapenem resistance in Escherichia coli

bioRxivJanuary 16, 2020
Caroline BoulouisEdwin Leeansyah

Mitogen-Activated Protein Kinase Inhibitors and T-Cell-Dependent Immunotherapy in Cancer

PharmaceuticalsJanuary 16, 2020
Sandeep KumarAjay Rana
Methods in Enzymology

A flow cytometry-based method to screen for modulators of tumor-specific T cell cytotoxicity

Methods in EnzymologyJanuary 18, 2020
Javier SantosSantos Mañes

Photochemical Internalization: Light Paves Way for New Cancer Chemotherapies and Vaccines

CancersJanuary 16, 2020
Lara ŠošićPål Johansen
European Journal of Immunology

CD5 blockade enhances ex vivo CD8+ T cell activation and tumour cell cytotoxicity

European Journal of ImmunologyJanuary 17, 2020
Faizah AlotaibiJames Koropatnick

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