Killing Mechanisms

Cytolytic t lymphocytes exert two main specific molecular killing mechanisms against target cells, namely (i) they can synthesize and release soluble cytolytic factors, and (ii) they can express effector molecules that act as ligands of receptors expressed by target cells on the cell surface. Here is the latest research on killing mechanisms.

August 2, 2020

Acrolein in cigarette smoke attenuates the innate immune responses mediated by surfactant protein D

Biochimica Et Biophysica Acta. General Subjects
Rina TakamiyaMiyako Nakano
August 1, 2020

Poor clinical outcomes and immunoevasive contexture in interleukin-9 abundant muscle-invasive bladder cancer

International Journal of Cancer. Journal International Du Cancer
Quan ZhouJiejie Xu
July 29, 2020
Preprint

Faster Cryptococcus melanization increases virulence in experimental and human cryptococcosis

BioRxiv : the Preprint Server for Biology
H. R. d. SousaAndré Moraes Nicola
August 1, 2020
Review
Open Access

Innate Immune Defense Mechanisms by Myeloid Cells That Hamper Cancer Immunotherapy

Frontiers in Immunology
Els LebeggeJo A Van Ginderachter
July 30, 2020
Review
Open Access

Mechanisms of Immune-Related Complications in Cancer Patients Treated with Immune Checkpoint Inhibitors

Pharmacology
David König, Heinz Läubli
August 1, 2020
Open Access

Rapid onset type 1 diabetes with anti-PD-1 directed therapy

Oncotarget
Karen YunSandip Pravin Patel
July 30, 2020
Preprint

NK cells integrate signals over large areas when building immune synapses but require local stimuli for degranulation

BioRxiv : the Preprint Server for Biology
Q. VerronB. Önfelt
July 30, 2020

Arming Cytotoxic Lymphocytes for Cancer Immunotherapy by Means of the NKG2D/NKG2D-Ligand System

Expert Opinion on Biological Therapy
Mariya LazarovaAlexander Steinle
July 30, 2020

The lymphocyte populations and their migration into the central nervous system in tick-borne encephalitis

Ticks and Tick-borne Diseases
Sambor GrygorczukMilena Dąbrowska
August 1, 2020
Open Access

Peptide Vaccine Combined Adjuvants Modulate Anti-tumor Effects of Radiation in Glioblastoma Mouse Model

Frontiers in Immunology
Thi-Anh-Thuy TranTae-Young Jung
August 1, 2020
Review

Cancer immunotherapy resistance based on immune checkpoints inhibitors: Targets, biomarkers, and remedies

Drug Resistance Updates : Reviews and Commentaries in Antimicrobial and Anticancer Chemotherapy
Elisabeth Pérez-RuizJavier De Las Rivas
July 29, 2020
Open Access

CD36-mediated uptake of myelin debris by macrophages and microglia reduces neuroinflammation

Journal of Neuroinflammation
Elien GrajchenJeroen F J Bogie
August 2, 2020

Human CLEC9A antibodies deliver NY-ESO-1 antigen to CD141+ dendritic cells to activate naïve and memory NY-ESO-1-specific CD8+ T cells

Journal for Immunotherapy of Cancer
Kelly-Anne MastermanKristen J Radford
August 2, 2020
Review

NKp30 - a prospective target for new cancer immunotherapy strategies

British Journal of Pharmacology
Pedro F PinheiroM Matilde Marques

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