Feed Preview

Going Viral

LRRK2 and Microtubules

LRRK2 and Microtubules diagram by Kateryna Kon, Shutterstock
Kateryna Kon, Shutterstock

Mutations in the LRRK2 gene are risk-factors for developing Parkinson’s disease (PD). LRRK2 mutations in PD have been shown to enhance its association with microtubules. Here is the latest research.

Top 20 most recent papers
Lancet Neurology

Clinical and dopamine transporter imaging characteristics of non-manifest LRRK2 and GBA mutation carriers in the Parkinson's Progression Markers Initiative (PPMI): a cross-sectional study

Lancet NeurologyNovember 4, 2019
Tanya SimuniPPMI Investigators
17
1
18
bioRxiv

The in situ structure of Parkinson's disease-linked LRRK2

bioRxivNovember 10, 2019
Reika WatanabeElizabeth Villa
164
21
bioRxiv

Parkinson's Disease-linked LRRK2 structure and model for microtubule interaction

bioRxivJanuary 6, 2020
Colin K DenistonAndres E Leschziner
62
bioRxiv

Pathway-specific deregulation of striatal excitatory synapses in LRRK2 mutations

bioRxivJanuary 4, 2020
Chuyu ChenLoukia Parisiadou
20
bioRxiv

The genetic architecture of Parkinson disease in Spain: characterizing population-specific risk, differential haplotype structures, and providing etiologic insight

bioRxivApril 18, 2019
Sara Bandres CigaInternatl Parkinson Disease Genomics Consortium
29
11
Autophagy

New insights into the interplay between autophagy, gut microbiota and inflammatory responses in IBD

AutophagyJuly 10, 2019
Anaïs LarabiHang Thi Thu Nguyen
10
81
bioRxiv

Structural basis for Rab8a GTPase recruitment of RILPL2 via LRRK2 phosphorylation of switch 2

bioRxivAugust 19, 2019
Amir R KhanEmma McGrath
12
bioRxiv

PINK1-dependent phosphorylation of Serine111 within the SF3 motif of Rab GTPases impairs effector interactions and LRRK2 mediated phosphorylation at Threonine72

bioRxivSeptember 12, 2019
Sophie ViewegMiratul Muqit
12
3
Bioorganic & Medicinal Chemistry Letters

Discovery of a class of highly potent Janus Kinase 1/2 (JAK1/2) inhibitors demonstrating effective cell-based blockade of IL-13 signaling

Bioorganic & Medicinal Chemistry LettersApril 15, 2019
Mark ZakAdam Johnson
3
7
International Journal of Molecular Sciences

SerThr-PhosphoProteome of Brain from Aged PINK1-KO+A53T-SNCA Mice Reveals pT1928-MAP1B and pS3781-ANK2 Deficits, as Hub between Autophagy and Synapse Changes

International Journal of Molecular SciencesJuly 7, 2019
Georg AuburgerNesli-Ece Sen
5
1
10
NPJ Parkinson's Disease

Modeling Parkinson's disease in midbrain-like organoids

NPJ Parkinson's DiseaseApril 10, 2019
Lisa M SmitsJens C Schwamborn
20
1
1
69
bioRxiv

Neurodegeneration caused by LRRK2-G2019S requires Rab10 in select dopaminergic neurons

bioRxivMarch 22, 2019
Stavroula PetridiChristopher J. H. Elliott
12
1
10
Neuroscience

Basal and Evoked Neurotransmitter Levels in Parkin, DJ-1, PINK1 and LRRK2 Knockout Rat Striatum

NeuroscienceApril 29, 2019
Rose B CreedMatthew S Goldberg
9
1
10
bioRxiv

A revised 1.6 Å structure of the GTPase domain of the Parkinson’s disease-associated protein LRRK2 provides insights into mechanisms

bioRxivJune 23, 2019
Chun-Xiang WuQuyen Q. Hoang
5
5
Biological Chemistry

Neuronal microtubules and proteins linked to Parkinson's disease: a relevant interaction?

Biological ChemistryJuly 1, 2019
Alessandra M CalogeroGraziella Cappelletti
2
1
9
ENeuro

The Mixed-Lineage Kinase Inhibitor URMC-099 Protects Hippocampal Synapses in Experimental Autoimmune Encephalomyelitis

ENeuroJanuary 11, 2019
Matthew J BellizziHarris A Gelbard
3
1
12
Journal of Neuroinflammation

Leucine-rich repeat kinase-2 (LRRK2) modulates paraquat-induced inflammatory sickness and stress phenotype

Journal of NeuroinflammationJune 9, 2019
Chris RudykCLINT membership
4
9
Frontiers in Neuroscience

Leucine-Rich Repeat Kinase 2 Is Associated With Activation of the Paraventricular Nucleus of the Hypothalamus and Stress-Related Gastrointestinal Dysmotility

Frontiers in NeuroscienceSeptember 27, 2019
Tatsunori MaekawaTakafumi Ichikawa
5
4
FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology

NEAT1 is overexpressed in Parkinson's disease substantia nigra and confers drug-inducible neuroprotection from oxidative stress

FASEB Journal : Official Publication of the Federation of American Societies for Experimental BiologyJuly 18, 2019
Alon SimchovitzHermona Soreq
2
1
9
Small GTPases

LRRK2 binds to the Rab32 subfamily in a GTP-dependent manner via its armadillo domain

Small GTPasesSeptember 26, 2019
Emma McGrathAmir R Khan
9
16

See more papers from this feed

Related Feeds

ALS

Amyotrophic Lateral Sclerosis (ALS), also known as motor neuron disease, is associated with the death of neurons that control voluntary muscles. Discover the latest research on ALS here.

ALS & FTD: TDP-43

ALS shares with a considerable proportion of FTD cases the same neuropathological substrate, namely, inclusions of abnormally phosphorylated protein tdp-43 (ptdp-43). Here are the latest discoveries pertaining to ptdp-43 and these diseases.

ALS - Pathogenic Mechanisms

Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disorder characterized by muscle weakness. Here is the latest research investigating pathogenic mechanisms that underlie this genetically heterogeneous disorder.

ALS - Phenotypes

Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disorder characterized by muscle weakness. Here is the latest research investigating phenotypes associated with this genetically heterogeneous disorder.

ALS: Genetics

Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disorder characterized by muscle weakness. ALS is a genetically heterogeneous disorder with several causative genes. Here are the latest discoveries pertaining to the genetics of this disease.

ALS: Prions

Prions are misfolded proteins which characterize several fatal neurodegenerative diseases. Prion-like mechanisms are associated with the pathogenesis of Amyotrophic Lateral Sclerosis (ALS). Here are the latest discoveries pertaining to this disease.

ALS: Stress Granules

Amyotrophic Lateral Sclerosis (ALS) is a neurodegenerative disease characterized by cytoplasmic protein aggregates within motor neurons. TDP-43 is an ALS-linked protein that is known to regulate splicing and storage of specific mRNAs into stress granules, which have been implicated in formation of ALS protein aggregates. Here is the latest research.

ALS: Therapies

Amyotrophic Lateral Sclerosis (ALS), also known as motor neuron disease, is associated with the death of neurons that control voluntary muscles. Discover the latest research on ALS therapies here.

ALS: Transposon de-silencing

Transposon silencing is a form of transcriptional gene silencing. These gene silencing mechanisms are impaired in Amyotrophic lateral sclerosis (ALS). Here are the latest discoveries pertaining to transposon silencing and this disease.

Age-related Dementia

Age-related dementia (Alzheimer's disease) results from the destructive impact of the pulse on cerebral vasculature. Evidence is reviewed that the neuropathology of the dementia is caused by the breakdown of small cerebral vessels (silent microbleeds), that the microbleeds result from pulse-induced damage to the cerebral vessels, and that pulse becomes increasingly destructive with age, because of the age-related stiffening of the aorta and great arteries, which causes an increase in the intensity of the pressure pulse. Discover the latest research on age-related dementia here.

© 2020 Meta ULC. All rights reserved
/feed-previews/lrrk2-and-microtubules/e1132ba7-7a6a-494b-8f07-c617e7d85d2a