LRRK2 & Microtubules

Mutations in the LRRK2 gene are risk-factors for developing Parkinson’s disease (PD). LRRK2 mutations in PD have been shown to enhance its association with microtubules. Here is the latest research.

October 22, 2020

"Opening" New Insights into LRRK2 Conformation and the Microtubule

Movement Disorders : Official Journal of the Movement Disorder Society
Diana A Olszewska, Anthony E Lang
May 24, 2016
Review
Open Access

The entangled ER-mitochondrial axis as a potential therapeutic strategy in neurodegeneration: A tangled duo unchained

Cell Calcium
Amit U JoshiDaria Mochly-Rosen
December 4, 2020
Review
Open Access

Pathological Functions of LRRK2 in Parkinson's Disease

Cells
Ga Ram Jeong, Byoung Dae Lee
May 16, 2017
Review
Open Access

Tale of the Good and the Bad Cdk5: Remodeling of the Actin Cytoskeleton in the Brain

Molecular Neurobiology
Kavita Shah, Sandra Rossie
November 10, 2019
Preprint
Open Access

The in situ structure of Parkinson's disease-linked LRRK2

BioRxiv : the Preprint Server for Biology
Reika WatanabeElizabeth Villa
February 14, 2019
Open Access

Podocytes and autophagy: a potential therapeutic target in lupus nephritis

Autophagy
Xu-Jie ZhouHong Zhang
May 10, 2018
Open Access

Tubulin and Tau: Possible targets for diagnosis of Parkinson's and Alzheimer's diseases

PloS One
Mohamed SalamaMohamed B Abou Donia
March 30, 2017

Mechanisms of Mutant LRRK2 Neurodegeneration

Advances in Neurobiology
Mark R Cookson
December 26, 2016
Review
Open Access

Altered microtubule dynamics in neurodegenerative disease: Therapeutic potential of microtubule-stabilizing drugs

Neurobiology of Disease
Kurt R BrundenCarlo Ballatore
July 12, 2019
Open Access

The dynamic switch mechanism that leads to activation of LRRK2 is embedded in the DFGψ motif in the kinase domain

Proceedings of the National Academy of Sciences of the United States of America
Sven H. SchmidtFriedrich W. Herberg
April 6, 2019
Open Access

Emerging views of mitophagy in immunity and autoimmune diseases

Autophagy
Ye XuZhihua Ran
August 20, 2020

Structure of LRRK2 in Parkinson's disease and model for microtubule interaction

Nature
Colin K DenistonAndres E Leschziner
December 23, 2019
Review
Open Access

LRRK2 Biology from structure to dysfunction: research progresses, but the themes remain the same

Molecular Neurodegeneration
Daniel C BerwickKirsten Harvey
December 22, 2020
Case Report
Open Access

A Specific Diplotype H1j/H2 of the MAPT Gene Could Be Responsible for Parkinson's Disease with Dementia

Case Reports in Genetics
Imane SmailiAhmed Bouhouche
February 17, 2017
Review
Open Access

LRRK2: from kinase to GTPase to microtubules and back

Biochemical Society Transactions
Marian Blanca RamírezSabine Hilfiker
July 1, 2019
Review
Open Access

Neuronal microtubules and proteins linked to Parkinson's disease: a relevant interaction?

Biological Chemistry
Alessandra M CalogeroGraziella Cappelletti
July 14, 2020
Preprint
Open Access

Conformation and dynamics of the kinase domain drive subcellular location and activation of LRRK2

BioRxiv : the Preprint Server for Biology
Sven H. SchmidtSusan S. Taylor
July 2, 2016

LRRK2 interferes with aggresome formation for autophagic clearance

Molecular and Cellular Neurosciences
Yeojin BangHyun Jin Choi
November 24, 2018
Review
Open Access

The role of LRRK2 in cytoskeletal dynamics

Biochemical Society Transactions
Laura CivieroElisa Greggio

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