Feed Preview

LRRK2 and Microtubules

LRRK2 and Microtubules diagram by Kateryna Kon, Shutterstock
Kateryna Kon, Shutterstock

Mutations in the LRRK2 gene are risk-factors for developing Parkinson’s disease (PD). LRRK2 mutations in PD have been shown to enhance its association with microtubules. Here is the latest research.

Top 20 most recent papers
Proceedings of the National Academy of Sciences of the United States of America

The dynamic switch mechanism that leads to activation of LRRK2 is embedded in the DFGψ motif in the kinase domain

Proceedings of the National Academy of Sciences of the United States of AmericaJuly 12, 2019
Sven H SchmidtFriedrich W Herberg
3
22
Genes

NLGenomeSweeper: A Tool for Genome-Wide NBS-LRR Resistance Gene Identification

GenesApril 5, 2020
Nicholas TodaPatricia Faivre-Rampant
Progress in Brain Research

Prodromal PD: A new nosological entity

Progress in Brain ResearchApril 6, 2020
Eva SchaefferDaniela Berg
bioRxiv

Pathogenic LRRK2 R1441C mutation is associated with striatal alterations

bioRxivMarch 12, 2020
Harry XeniasLoukia Parisiadou
8
bioRxiv

Interferon-γ signaling synergizes with LRRK2 in human neurons and microglia

bioRxivJanuary 31, 2020
Silvia De CiccoMichela Deleidi
3
Molecular Neurodegeneration

LRRK2 Biology from structure to dysfunction: research progresses, but the themes remain the same

Molecular NeurodegenerationDecember 23, 2019
Daniel C BerwickKirsten Harvey
15
Movement Disorders : Official Journal of the Movement Disorder Society

The Genetic Architecture of Parkinson Disease in Spain: Characterizing Population-Specific Risk, Differential Haplotype Structures, and Providing Etiologic Insight

Movement Disorders : Official Journal of the Movement Disorder SocietyOctober 30, 2019
Sara Bandres-CigaInternational Parkinson Disease Genomics Consortium
36
2
12
Current Protocols in Neuroscience

Back and to the Future: From Neurotoxin-Induced to Human Parkinson's Disease Models

Current Protocols in NeuroscienceFebruary 13, 2020
Mikko AiravaaraAndrii Domanskyi
15
1
Journal of Clinical Medicine

Variants in Miro1 Cause Alterations of ER-Mitochondria Contact Sites in Fibroblasts from Parkinson's Disease Patients

Journal of Clinical MedicineJanuary 1, 2020
Clara Berenguer-EscuderRejko Krüger
2
1
bioRxiv

LRRK2 mediates tubulation and vesicle sorting from membrane damaged lysosomes

bioRxivJanuary 24, 2020
Luis Bonet-PonceMark R. Cookson
79
10
2
Plant Physiology

The NLR-Annotator tool enables annotation of the intracellular immune receptor repertoire

Plant PhysiologyMarch 19, 2020
Burkhard SteuernagelBrande B Wulff
64
Plant Biotechnology Journal

Characterization of disease resistance genes in the Brassica napus pangenome reveals significant structural variation

Plant Biotechnology JournalSeptember 26, 2019
Aria DolatabadianJacqueline Batley
15
1
9

See more papers from this feed

Related Feeds

ALS

Amyotrophic Lateral Sclerosis (ALS), also known as motor neuron disease, is associated with the death of neurons that control voluntary muscles. Discover the latest research on ALS here.

ALS & FTD: TDP-43

ALS shares with a considerable proportion of FTD cases the same neuropathological substrate, namely, inclusions of abnormally phosphorylated protein tdp-43 (ptdp-43). Here are the latest discoveries pertaining to ptdp-43 and these diseases.

ALS - Pathogenic Mechanisms

Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disorder characterized by muscle weakness. Here is the latest research investigating pathogenic mechanisms that underlie this genetically heterogeneous disorder.

ALS - Phenotypes

Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disorder characterized by muscle weakness. Here is the latest research investigating phenotypes associated with this genetically heterogeneous disorder.

ALS: Genetics

Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disorder characterized by muscle weakness. ALS is a genetically heterogeneous disorder with several causative genes. Here are the latest discoveries pertaining to the genetics of this disease.

ALS: Prions

Prions are misfolded proteins which characterize several fatal neurodegenerative diseases. Prion-like mechanisms are associated with the pathogenesis of Amyotrophic Lateral Sclerosis (ALS). Here are the latest discoveries pertaining to this disease.

ALS: Stress Granules

Amyotrophic Lateral Sclerosis (ALS) is a neurodegenerative disease characterized by cytoplasmic protein aggregates within motor neurons. TDP-43 is an ALS-linked protein that is known to regulate splicing and storage of specific mRNAs into stress granules, which have been implicated in formation of ALS protein aggregates. Here is the latest research.

ALS: Therapies

Amyotrophic Lateral Sclerosis (ALS), also known as motor neuron disease, is associated with the death of neurons that control voluntary muscles. Discover the latest research on ALS therapies here.

ALS: Transposon de-silencing

Transposon silencing is a form of transcriptional gene silencing. These gene silencing mechanisms are impaired in Amyotrophic lateral sclerosis (ALS). Here are the latest discoveries pertaining to transposon silencing and this disease.

Age-related Dementia

Age-related dementia (Alzheimer's disease) results from the destructive impact of the pulse on cerebral vasculature. Evidence is reviewed that the neuropathology of the dementia is caused by the breakdown of small cerebral vessels (silent microbleeds), that the microbleeds result from pulse-induced damage to the cerebral vessels, and that pulse becomes increasingly destructive with age, because of the age-related stiffening of the aorta and great arteries, which causes an increase in the intensity of the pressure pulse. Discover the latest research on age-related dementia here.

© 2020 Meta ULC. All rights reserved
/feed-previews/lrrk2-and-microtubules/e1132ba7-7a6a-494b-8f07-c617e7d85d2a