LRRK2 & Immunity during Infection

LRRK2 has been shown to function as a central regulator of vesicular trafficking, infection, immunity, and inflammation. Mutations in the LRRK2 gene are a risk-factor for developing Parkinson’s disease. Here is the latest research on the role of this kinase on immunity during infection.

August 20, 2021

Age-related LRRK2 G2019S Mutation Impacts Microglial Dopaminergic Fiber Refinement and Synaptic Pruning Involved in Abnormal Behaviors.

Journal of Molecular Neuroscience : MN
Qiuyang ZhangXiaodong Pan
August 3, 2021
Review
Open Access

Genetic Imaging of Neuroinflammation in Parkinson's Disease: Recent Advancements.

Frontiers in Cell and Developmental Biology
Longping YaoGuohui Lu
July 23, 2021
Review
Open Access

PARK Genes Link Mitochondrial Dysfunction and Alpha-Synuclein Pathology in Sporadic Parkinson's Disease.

Frontiers in Cell and Developmental Biology
Wen LiCarolyn M Sue
July 9, 2021
Review
Open Access

Genetic Defects and Pro-inflammatory Cytokines in Parkinson's Disease.

Frontiers in Neurology
Albert Frank MagnusenManoj Kumar Pandey
June 25, 2021
Open Access

LRRK2-NFATc2 Pathway Associated with Neuroinflammation May Be a Potential Therapeutic Target for Parkinson's Disease.

Journal of Inflammation Research
Youcui WangJunxia Xie
May 18, 2021
Open Access

Mutations in GBA and LRRK2 Are Not Associated with Increased Inflammatory Markers.

Journal of Parkinson's Disease
Avner ThalerAnat Mirelman
March 26, 2021
Preprint
Open Access

Early onset leprosy reveals a joint effect of LRRK2 and NOD2 variants

MedRxiv : the Preprint Server for Health Sciences
M. Dallmann-SauerErwin Schurr
November 12, 2020
Review
Open Access

The roles and functions of Paneth cells in Crohn's disease: A critical review

Cell Proliferation
Erpeng Yang, Jun Shen
September 30, 2020
Open Access

Identification of Potential Biomarkers and Related Transcription Factors in Peripheral Blood of Tuberculosis Patients

International Journal of Environmental Research and Public Health
Longxiang XieJianping Xie
August 13, 2020
Preprint
Open Access

Whole genome CRISPR screens identify LRRK2-regulated endocytosis as a major mechanism for extracellular tau uptake by human neurons

BioRxiv : the Preprint Server for Biology
L. D. EvansFrederick J Livesey
June 9, 2020
Review
Open Access

LRRK2 at the Interface Between Peripheral and Central Immune Function in Parkinson's.

Frontiers in Neuroscience
Rebecca L WallingsMalú G Tansey
June 6, 2020
Open Access

LRRK2 Kinase Inhibition Rescues Deficits in Lysosome Function Due to Heterozygous GBA1 Expression in Human iPSC-Derived Neurons

Frontiers in Neuroscience
Anwesha SanyalMatthew J LaVoie
May 21, 2020
Open Access

Association of NOD2 and IFNG single nucleotide polymorphisms with leprosy in the Amazon ethnic admixed population

PLoS Neglected Tropical Diseases
André Luiz LeturiondoCarolina Talhari
April 6, 2020
Open Access

Leucine-rich repeat kinase-2 (LRRK2) modulates microglial phenotype and dopaminergic neurodegeneration

Neurobiology of Aging
Zach DwyerCLINT (Canadian LRRK2 in inflammation team)

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