LRRK2 & Immunity During Infection

Mutations in the LRRK2 gene are a risk-factor for developing Parkinson’s disease. However, LRRK2 has been shown to function as a central regulator of vesicular trafficking, infection, immunity, and inflammation. Here is the latest research on the role of this kinase on immunity during infection.

October 19, 2019
Open Access

Physiological and pathological roles of LRRK2 in the nuclear envelope integrity

Human Molecular Genetics
Vered ShaniSimone Engelender
December 10, 2019
Review

The LRRK2-RAB axis in regulation of vesicle trafficking and α-synuclein propagation

Biochimica Et Biophysica Acta. Molecular Basis of Disease
Eun-Jin Bae, Seung-Jae Lee
September 16, 2020

Somatic mutations in LRRK2 identify a subset of invasive mammary carcinomas associated with high mutation burden

The American Journal of Pathology
Edgardo R Parrilla CastellarLaurie H Sanders
June 6, 2020
Open Access

LRRK2 Kinase Inhibition Rescues Deficits in Lysosome Function Due to Heterozygous GBA1 Expression in Human iPSC-Derived Neurons

Frontiers in Neuroscience
Anwesha SanyalMatthew J LaVoie
October 22, 2019
Open Access

Accumulation of mitochondrial 7S DNA in idiopathic and LRRK2 associated Parkinson's disease

EBioMedicine
Petar PodlesniyRamon Trullas
November 27, 2019
Open Access

LRRK2 regulation of immune-pathways and inflammatory disease

Biochemical Society Transactions
Rebecca L Wallings, Malú Gámez Tansey
March 27, 2020
Review
Open Access

Leucine Rich Repeat Kinase 2 and Innate Immunity

Frontiers in Neuroscience
Diba Ahmadi Rastegar, Nicolas Dzamko
February 9, 2020

Lysosome and Inflammatory Defects in GBA1-Mutant Astrocytes Are Normalized by LRRK2 Inhibition

Movement Disorders : Official Journal of the Movement Disorder Society
Anwesha SanyalMatthew J LaVoie
August 3, 2019
Open Access

Parkinson's progression prediction using machine learning and serum cytokines

NPJ Parkinson's Disease
Diba Ahmadi RastegarNicolas Dzamko
December 23, 2019
Review
Open Access

LRRK2 Biology from structure to dysfunction: research progresses, but the themes remain the same

Molecular Neurodegeneration
Daniel C BerwickKirsten Harvey
August 20, 2019
Open Access

Low prevalence of known pathogenic mutations in dominant PD genes: A Swedish multicenter study

Parkinsonism & Related Disorders
Andreas PuschmannMaria Swanberg
November 16, 2019
Comment / Editorial

Expert comment: "A case of missing pathology in a patient with LRRK2 Parkinson's disease"

Parkinsonism & Related Disorders
Lorraine V Kalia

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