LRRK2 & Immunity During Infection (MDS)

Mutations in the LRRK2 gene are a risk-factor for developing Parkinson’s disease. However, LRRK2 has been shown to function as a central regulator of vesicular trafficking, infection, immunity, and inflammation. Here is the latest research on the role of this kinase on immunity during infection.

May 30, 2017
Open Access

Leucine-Rich Repeat Kinase 2 (LRRK2) Stimulates IL-1β-Mediated Inflammatory Signaling through Phosphorylation of RCAN1

Frontiers in Cellular Neuroscience
Kyung A HanKwang C Chung
March 3, 2018

Disruption of LRRK2 in Zebrafish leads to hyperactivity and weakened antibacterial response

Biochemical and Biophysical Research Communications
Donglai ShengJianjun Liu
May 26, 2018
Open Access

The rice blast resistance gene Ptr encodes an atypical protein required for broad-spectrum disease resistance

Nature Communications
Haijun ZhaoYinong Yang
March 30, 2017

LRRK2 and the Immune System

Advances in Neurobiology
Nicolas Dzamko
June 6, 2020
Open Access

LRRK2 Kinase Inhibition Rescues Deficits in Lysosome Function Due to Heterozygous GBA1 Expression in Human iPSC-Derived Neurons

Frontiers in Neuroscience
Anwesha SanyalMatthew J LaVoie
February 14, 2019
Open Access

Podocytes and autophagy: a potential therapeutic target in lupus nephritis

Autophagy
Xu-Jie ZhouHong Zhang
November 27, 2019
Open Access

LRRK2 regulation of immune-pathways and inflammatory disease

Biochemical Society Transactions
Rebecca L Wallings, Malú Gámez Tansey
June 14, 2019
Review
Open Access

Exploring the "Multiple-Hit Hypothesis" of Neurodegenerative Disease: Bacterial Infection Comes Up to Bat

Frontiers in Cellular and Infection Microbiology
Kristin PatrickRobert O Watson
March 27, 2020
Review
Open Access

Leucine Rich Repeat Kinase 2 and Innate Immunity

Frontiers in Neuroscience
Diba Ahmadi Rastegar, Nicolas Dzamko
February 9, 2020

Lysosome and Inflammatory Defects in GBA1-Mutant Astrocytes Are Normalized by LRRK2 Inhibition

Movement Disorders : Official Journal of the Movement Disorder Society
Anwesha SanyalMatthew J LaVoie
August 3, 2019
Open Access

Parkinson's progression prediction using machine learning and serum cytokines

NPJ Parkinson's Disease
Diba Ahmadi RastegarNicolas Dzamko
May 31, 2017
Open Access

Gene expression patterns induced at different stages of rhinovirus infection in human alveolar epithelial cells

PloS One
Mohammad Reza EtemadiZamberi Sekawi
April 6, 2019
Open Access

Emerging views of mitophagy in immunity and autoimmune diseases

Autophagy
Ye XuZhihua Ran
April 7, 2017
Open Access

Discovery of Novel Small-Molecule Inhibitors of LIM Domain Kinase for Inhibiting HIV-1

Journal of Virology
Fei YiYuntao Wu
September 13, 2017

The impact of murine LRRK2 G2019S transgene overexpression on acute responses to inflammatory challenge

Brain, Behavior, and Immunity
Darcy LitteljohnCanadian Lrrk2 in Inflammation Team (CLINT)

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